Approaches to in vitro tissue regeneration with application for human disease modeling and drug development
Reliable in vitro human disease models that capture the complexity of in vivo tissue behaviors are crucial to gain mechanistic insights into human disease and enable the development of treatments that are effective across broad patient populations. The integration of stem cell technologies, tissue e...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2015
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| Online Access: | http://hdl.handle.net/1721.1/99479 https://orcid.org/0000-0002-8581-1261 https://orcid.org/0000-0002-1801-5548 |
| _version_ | 1826203412834811904 |
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| author | Young, Carissa L. Lauffenburger, Douglas A. Griffith, Linda G. Borenstein, Jeffrey T. Ebrahimkhani, Mohammad Reza |
| author2 | Massachusetts Institute of Technology. Center for Gynepathology Research |
| author_facet | Massachusetts Institute of Technology. Center for Gynepathology Research Young, Carissa L. Lauffenburger, Douglas A. Griffith, Linda G. Borenstein, Jeffrey T. Ebrahimkhani, Mohammad Reza |
| author_sort | Young, Carissa L. |
| collection | MIT |
| description | Reliable in vitro human disease models that capture the complexity of in vivo tissue behaviors are crucial to gain mechanistic insights into human disease and enable the development of treatments that are effective across broad patient populations. The integration of stem cell technologies, tissue engineering, emerging biomaterials strategies and microfabrication processes, as well as computational and systems biology approaches, is enabling new tools to generate reliable in vitro systems to study the molecular basis of human disease and facilitate drug development. In this review, we discuss these recently developed tools and emphasize opportunities and challenges involved in combining these technologies toward regenerative science. |
| first_indexed | 2024-09-23T12:36:11Z |
| format | Article |
| id | mit-1721.1/99479 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:36:11Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/994792022-09-28T08:55:33Z Approaches to in vitro tissue regeneration with application for human disease modeling and drug development Young, Carissa L. Lauffenburger, Douglas A. Griffith, Linda G. Borenstein, Jeffrey T. Ebrahimkhani, Mohammad Reza Massachusetts Institute of Technology. Center for Gynepathology Research Massachusetts Institute of Technology. Department of Biological Engineering Ebrahimkhani, Mohammad Reza Young, Carissa L. Lauffenburger, Douglas A. Griffith, Linda G. Reliable in vitro human disease models that capture the complexity of in vivo tissue behaviors are crucial to gain mechanistic insights into human disease and enable the development of treatments that are effective across broad patient populations. The integration of stem cell technologies, tissue engineering, emerging biomaterials strategies and microfabrication processes, as well as computational and systems biology approaches, is enabling new tools to generate reliable in vitro systems to study the molecular basis of human disease and facilitate drug development. In this review, we discuss these recently developed tools and emphasize opportunities and challenges involved in combining these technologies toward regenerative science. National Institute for Biomedical Imaging and Bioengineering (U.S.) (Grant 5R01EB010246-02) National Center for Advancing Translational Sciences (U.S.) (Grant 1UH2TR000496) United States. Defense Advanced Research Projects Agency (Cooperative Agreement W911NF-12-2-0039) 2015-10-27T17:40:25Z 2015-10-27T17:40:25Z 2014-05 Article http://purl.org/eprint/type/JournalArticle 13596446 http://hdl.handle.net/1721.1/99479 Ebrahimkhani, Mohammad R., Carissa L. Young, Douglas A. Lauffenburger, Linda G. Griffith, and Jeffrey T. Borenstein. “Approaches to in Vitro Tissue Regeneration with Application for Human Disease Modeling and Drug Development.” Drug Discovery Today 19, no. 6 (June 2014): 754–762. https://orcid.org/0000-0002-8581-1261 https://orcid.org/0000-0002-1801-5548 en_US http://dx.doi.org/10.1016/j.drudis.2014.04.017 Drug Discovery Today Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Young, Carissa L. Lauffenburger, Douglas A. Griffith, Linda G. Borenstein, Jeffrey T. Ebrahimkhani, Mohammad Reza Approaches to in vitro tissue regeneration with application for human disease modeling and drug development |
| title | Approaches to in vitro tissue regeneration with application for human disease modeling and drug development |
| title_full | Approaches to in vitro tissue regeneration with application for human disease modeling and drug development |
| title_fullStr | Approaches to in vitro tissue regeneration with application for human disease modeling and drug development |
| title_full_unstemmed | Approaches to in vitro tissue regeneration with application for human disease modeling and drug development |
| title_short | Approaches to in vitro tissue regeneration with application for human disease modeling and drug development |
| title_sort | approaches to in vitro tissue regeneration with application for human disease modeling and drug development |
| url | http://hdl.handle.net/1721.1/99479 https://orcid.org/0000-0002-8581-1261 https://orcid.org/0000-0002-1801-5548 |
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