Enhanced immune activation linked to endotoxemia in HIV-1 seronegative men who have sex with men

Enhanced immune activation linked to endotoxemia in HIV-1 seronegative men who have sex with men

This study assessed cellular and soluble markers of immune activation in HIV-1 seronegative MSM. MSM immune profiles were characterized by an increased expression of CD57 on T cells and endotoxemia. Endotoxin presence was linked to recent high-risk exposure and associated with elevated cytokine leve...

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Bibliographic Details
Main Authors: Palmer, Christine D., Tomassilli, Julia, Sirignano, Michael, Romero-Tejeda, Marisol, Arnold, Kelly B., Che, Denise, Lauffenburger, Douglas A., Jost, Stephanie, Allen, Todd, Mayer, Kenneth H., Altfeld, Marcus
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Lippincott Williams & Wilkins 2015
Online Access:http://hdl.handle.net/1721.1/99481
https://orcid.org/0000-0002-6028-5920
Description
Summary:This study assessed cellular and soluble markers of immune activation in HIV-1 seronegative MSM. MSM immune profiles were characterized by an increased expression of CD57 on T cells and endotoxemia. Endotoxin presence was linked to recent high-risk exposure and associated with elevated cytokine levels and decreased CD4+/CD8+ T cell ratios. Taken together, these data show elevated levels of inflammation linked to periods of endotoxemia resulting in a significantly different immune phenotype in a subset of MSM at a high risk of HIV-1 acquisition.

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