VTA neurons coordinate with the hippocampal reactivation of spatial experience
Spatial learning requires the hippocampus, and the replay of spatial sequences during hippocampal sharp wave-ripple (SPW-R) events of quiet wakefulness and sleep is believed to play a crucial role. To test whether the coordination of VTA reward prediction error signals with these replayed spatial se...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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eLife Sciences Publications, Ltd.
2015
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| Online Access: | http://hdl.handle.net/1721.1/99643 https://orcid.org/0000-0001-7149-3584 |
| _version_ | 1811075145927753728 |
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| author | Kloosterman, Fabian Gomperts, Stephen N. Wilson, Matthew A. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Kloosterman, Fabian Gomperts, Stephen N. Wilson, Matthew A. |
| author_sort | Kloosterman, Fabian |
| collection | MIT |
| description | Spatial learning requires the hippocampus, and the replay of spatial sequences during hippocampal sharp wave-ripple (SPW-R) events of quiet wakefulness and sleep is believed to play a crucial role. To test whether the coordination of VTA reward prediction error signals with these replayed spatial sequences could contribute to this process, we recorded from neuronal ensembles of the hippocampus and VTA as rats performed appetitive spatial tasks and subsequently slept. We found that many reward responsive (RR) VTA neurons coordinated with quiet wakefulness-associated hippocampal SPW-R events that replayed recent experience. In contrast, coordination between RR neurons and SPW-R events in subsequent slow wave sleep was diminished. Together, these results indicate distinct contributions of VTA reinforcement activity associated with hippocampal spatial replay to the processing of wake and SWS-associated spatial memory. |
| first_indexed | 2024-09-23T10:01:33Z |
| format | Article |
| id | mit-1721.1/99643 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:01:33Z |
| publishDate | 2015 |
| publisher | eLife Sciences Publications, Ltd. |
| record_format | dspace |
| spelling | mit-1721.1/996432022-09-26T15:14:14Z VTA neurons coordinate with the hippocampal reactivation of spatial experience Kloosterman, Fabian Gomperts, Stephen N. Wilson, Matthew A. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Gomperts, Stephen N. Wilson, Matthew A. Spatial learning requires the hippocampus, and the replay of spatial sequences during hippocampal sharp wave-ripple (SPW-R) events of quiet wakefulness and sleep is believed to play a crucial role. To test whether the coordination of VTA reward prediction error signals with these replayed spatial sequences could contribute to this process, we recorded from neuronal ensembles of the hippocampus and VTA as rats performed appetitive spatial tasks and subsequently slept. We found that many reward responsive (RR) VTA neurons coordinated with quiet wakefulness-associated hippocampal SPW-R events that replayed recent experience. In contrast, coordination between RR neurons and SPW-R events in subsequent slow wave sleep was diminished. Together, these results indicate distinct contributions of VTA reinforcement activity associated with hippocampal spatial replay to the processing of wake and SWS-associated spatial memory. National Institutes of Health (U.S.) (Grant R01-MH061976) United States. Office of Naval Research. Multidisciplinary University Research Initiative (Grant N00014-10-1-0936) National Institutes of Health (U.S.) (Mentored Grant K08-MH-81207-01A1) 2015-11-02T16:59:04Z 2015-11-02T16:59:04Z 2015-10 2014-10 Article http://purl.org/eprint/type/JournalArticle 2050-084X http://hdl.handle.net/1721.1/99643 Gomperts, Stephen N, Fabian Kloosterman, and Matthew A Wilson. “VTA Neurons Coordinate with the Hippocampal Reactivation of Spatial Experience.” eLife 4 (October 14, 2015). https://orcid.org/0000-0001-7149-3584 en_US http://dx.doi.org/10.7554/eLife.05360 eLife Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf eLife Sciences Publications, Ltd. eLife Sciences Publications, Ltd. |
| spellingShingle | Kloosterman, Fabian Gomperts, Stephen N. Wilson, Matthew A. VTA neurons coordinate with the hippocampal reactivation of spatial experience |
| title | VTA neurons coordinate with the hippocampal reactivation of spatial experience |
| title_full | VTA neurons coordinate with the hippocampal reactivation of spatial experience |
| title_fullStr | VTA neurons coordinate with the hippocampal reactivation of spatial experience |
| title_full_unstemmed | VTA neurons coordinate with the hippocampal reactivation of spatial experience |
| title_short | VTA neurons coordinate with the hippocampal reactivation of spatial experience |
| title_sort | vta neurons coordinate with the hippocampal reactivation of spatial experience |
| url | http://hdl.handle.net/1721.1/99643 https://orcid.org/0000-0001-7149-3584 |
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