Highly Selective Palladium-Catalyzed Cross-Coupling of Secondary Alkylzinc Reagents with Heteroaryl Halides
The highly selective palladium-catalyzed Negishi coupling of secondary alkylzinc reagents with heteroaryl halides is described. The development of a series of biarylphosphine ligands has led to the identification of an improved catalyst for the coupling of electron-deficient heterocyclic substrates....
Main Authors: | Yang, Yang, Niedermann, Katrin, Han, Chong, Buchwald, Stephen Leffler |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Chemistry |
Format: | Article |
Language: | en_US |
Published: |
American Chemical Society (ACS)
2015
|
Online Access: | http://hdl.handle.net/1721.1/99659 https://orcid.org/0000-0003-3875-4775 |
Similar Items
-
Negishi Coupling of Secondary Alkylzinc Halides with Aryl Bromides and Chlorides
by: Han, Chong, et al.
Published: (2013) -
Palladium-Catalyzed Hydroxylation of Aryl and Heteroaryl Halides Enabled by the Use of a Palladacycle Precatalyst
by: Cheung, Chi Wai, et al.
Published: (2015) -
Palladium-catalyzed coupling of functionalized primary and secondary amines with aryl and heteroaryl halides: two ligands suffice in most cases
by: Maiti, Debabrata, et al.
Published: (2015) -
In-Depth Assessment of the Palladium-Catalyzed Fluorination of Five-Membered Heteroaryl Bromides
by: Milner, Phillip John, et al.
Published: (2017) -
Ligand-Controlled Palladium-Catalyzed Regiodivergent Suzuki–Miyaura Cross-Coupling of Allylboronates and Aryl Halides
by: Yang, Yang, et al.
Published: (2015)