Macro-to-Micro Interface for the Control of Cellular Organization
The spatial organization of cellular communities plays a fundamental role in determining intercellular communication and emergent behavior. Few tools, however, exist to modulate tissue organization at the scale of individual cells, particularly in the case of dynamic manipulation. Micromechanical re...
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| Format: | Article |
| Language: | en_US |
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Institute of Electrical and Electronics Engineers (IEEE)
2015
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| Online Access: | http://hdl.handle.net/1721.1/99869 https://orcid.org/0000-0002-1293-2097 |
| _version_ | 1826213519390932992 |
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| author | Hui, Elliot E. Li, Chun Agrawal, Amit Bhatia, Sangeeta N. |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Hui, Elliot E. Li, Chun Agrawal, Amit Bhatia, Sangeeta N. |
| author_sort | Hui, Elliot E. |
| collection | MIT |
| description | The spatial organization of cellular communities plays a fundamental role in determining intercellular communication and emergent behavior. Few tools, however, exist to modulate tissue organization at the scale of individual cells, particularly in the case of dynamic manipulation. Micromechanical reconfigurable culture achieves dynamic control of tissue organization by culturing adherent cells on microfabricated plates that can be shifted to reorganize the arrangement of the cells. Although biological studies using this approach have been previously reported, this paper focuses on the engineering of the device, including the mechanism for translating manual manipulation to precise microscale position control, fault-tolerant design for manufacture, and the synthetic-to-living interface. |
| first_indexed | 2024-09-23T15:50:32Z |
| format | Article |
| id | mit-1721.1/99869 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:50:32Z |
| publishDate | 2015 |
| publisher | Institute of Electrical and Electronics Engineers (IEEE) |
| record_format | dspace |
| spelling | mit-1721.1/998692022-09-29T16:30:37Z Macro-to-Micro Interface for the Control of Cellular Organization Hui, Elliot E. Li, Chun Agrawal, Amit Bhatia, Sangeeta N. Harvard University--MIT Division of Health Sciences and Technology Hui, Elliot E. Li, Chun Agrawal, Amit Bhatia, Sangeeta N. The spatial organization of cellular communities plays a fundamental role in determining intercellular communication and emergent behavior. Few tools, however, exist to modulate tissue organization at the scale of individual cells, particularly in the case of dynamic manipulation. Micromechanical reconfigurable culture achieves dynamic control of tissue organization by culturing adherent cells on microfabricated plates that can be shifted to reorganize the arrangement of the cells. Although biological studies using this approach have been previously reported, this paper focuses on the engineering of the device, including the mechanism for translating manual manipulation to precise microscale position control, fault-tolerant design for manufacture, and the synthetic-to-living interface. National Science Foundation (U.S.) (Faculty Early Career Development Program) National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) David & Lucile Packard Foundation National Institutes of Health (U.S.). Ruth L. Kirschstein National Research Service Award 2015-11-10T13:04:17Z 2015-11-10T13:04:17Z 2014-03 2013-07 Article http://purl.org/eprint/type/JournalArticle 1057-7157 1941-0158 http://hdl.handle.net/1721.1/99869 Hui, Elliot E., Chun Li, Amit Agrawal, and Sangeeta N. Bhatia. “Macro-to-Micro Interface for the Control of Cellular Organization.” J. Microelectromech. Syst. 23, no. 2 (April 2014): 391–397. https://orcid.org/0000-0002-1293-2097 en_US http://dx.doi.org/10.1109/jmems.2013.2278813 Journal of Microelectromechanical Systems Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Institute of Electrical and Electronics Engineers (IEEE) PMC |
| spellingShingle | Hui, Elliot E. Li, Chun Agrawal, Amit Bhatia, Sangeeta N. Macro-to-Micro Interface for the Control of Cellular Organization |
| title | Macro-to-Micro Interface for the Control of Cellular Organization |
| title_full | Macro-to-Micro Interface for the Control of Cellular Organization |
| title_fullStr | Macro-to-Micro Interface for the Control of Cellular Organization |
| title_full_unstemmed | Macro-to-Micro Interface for the Control of Cellular Organization |
| title_short | Macro-to-Micro Interface for the Control of Cellular Organization |
| title_sort | macro to micro interface for the control of cellular organization |
| url | http://hdl.handle.net/1721.1/99869 https://orcid.org/0000-0002-1293-2097 |
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