New Methods in Tissue Engineering: Improved Models for Viral Infection
New insights in the study of virus and host biology in the context of viral infection are made possible by the development of model systems that faithfully recapitulate the in vivo viral life cycle. Standard tissue culture models lack critical emergent properties driven by cellular organization and...
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| Format: | Article |
| Language: | en_US |
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Annual Reviews
2015
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| Online Access: | http://hdl.handle.net/1721.1/99889 https://orcid.org/0000-0001-6214-4788 https://orcid.org/0000-0002-1293-2097 |
| _version_ | 1811089238449455104 |
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| author | Ramanan, Vyas Scull, Margaret A. Sheahan, Timothy P. Rice, Charles M. Bhatia, Sangeeta N |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Ramanan, Vyas Scull, Margaret A. Sheahan, Timothy P. Rice, Charles M. Bhatia, Sangeeta N |
| author_sort | Ramanan, Vyas |
| collection | MIT |
| description | New insights in the study of virus and host biology in the context of viral infection are made possible by the development of model systems that faithfully recapitulate the in vivo viral life cycle. Standard tissue culture models lack critical emergent properties driven by cellular organization and in vivo–like function, whereas animal models suffer from limited susceptibility to relevant human viruses and make it difficult to perform detailed molecular manipulation and analysis. Tissue engineering techniques may enable virologists to create infection models that combine the facile manipulation and readouts of tissue culture with the virus-relevant complexity of animal models. Here, we review the state of the art in tissue engineering and describe how tissue engineering techniques may alleviate some common shortcomings of existing models of viral infection, with a particular emphasis on hepatotropic viruses. We then discuss possible future applications of tissue engineering to virology, including current challenges and potential solutions. |
| first_indexed | 2024-09-23T14:16:01Z |
| format | Article |
| id | mit-1721.1/99889 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:16:01Z |
| publishDate | 2015 |
| publisher | Annual Reviews |
| record_format | dspace |
| spelling | mit-1721.1/998892022-09-28T19:36:20Z New Methods in Tissue Engineering: Improved Models for Viral Infection Ramanan, Vyas Scull, Margaret A. Sheahan, Timothy P. Rice, Charles M. Bhatia, Sangeeta N Massachusetts Institute of Technology. Institute for Medical Engineering & Science Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Koch Institute for Integrative Cancer Research at MIT Ramanan, Vyas Bhatia, Sangeeta N. New insights in the study of virus and host biology in the context of viral infection are made possible by the development of model systems that faithfully recapitulate the in vivo viral life cycle. Standard tissue culture models lack critical emergent properties driven by cellular organization and in vivo–like function, whereas animal models suffer from limited susceptibility to relevant human viruses and make it difficult to perform detailed molecular manipulation and analysis. Tissue engineering techniques may enable virologists to create infection models that combine the facile manipulation and readouts of tissue culture with the virus-relevant complexity of animal models. Here, we review the state of the art in tissue engineering and describe how tissue engineering techniques may alleviate some common shortcomings of existing models of viral infection, with a particular emphasis on hepatotropic viruses. We then discuss possible future applications of tissue engineering to virology, including current challenges and potential solutions. Hertz Foundation (Fellowship) National Science Foundation (U.S.). Graduate Research Fellowship National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) (Grant DK085713) Skolkovo Institute of Science and Technology (Grant 022423-003) 2015-11-10T18:13:42Z 2015-11-10T18:13:42Z 2014-09 Article http://purl.org/eprint/type/JournalArticle 2327-056X 2327-0578 http://hdl.handle.net/1721.1/99889 Ramanan, Vyas, Margaret A. Scull, Timothy P. Sheahan, Charles M. Rice, and Sangeeta N. Bhatia. “New Methods in Tissue Engineering: Improved Models for Viral Infection.” Annual Review of Virology 1, no. 1 (November 3, 2014): 475–499. https://orcid.org/0000-0001-6214-4788 https://orcid.org/0000-0002-1293-2097 en_US http://dx.doi.org/10.1146/annurev-virology-031413-085437 Annual Review of Virology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Annual Reviews PMC |
| spellingShingle | Ramanan, Vyas Scull, Margaret A. Sheahan, Timothy P. Rice, Charles M. Bhatia, Sangeeta N New Methods in Tissue Engineering: Improved Models for Viral Infection |
| title | New Methods in Tissue Engineering: Improved Models for Viral Infection |
| title_full | New Methods in Tissue Engineering: Improved Models for Viral Infection |
| title_fullStr | New Methods in Tissue Engineering: Improved Models for Viral Infection |
| title_full_unstemmed | New Methods in Tissue Engineering: Improved Models for Viral Infection |
| title_short | New Methods in Tissue Engineering: Improved Models for Viral Infection |
| title_sort | new methods in tissue engineering improved models for viral infection |
| url | http://hdl.handle.net/1721.1/99889 https://orcid.org/0000-0001-6214-4788 https://orcid.org/0000-0002-1293-2097 |
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