Anti-HIV-1 nanotherapeutics : promises and challenges for the future
The advent of highly active antiretroviral therapy (HAART) has significantly improved the prognosis for human immunodeficiency virus (HIV)-infected patients, however the adverse side effects associated with prolonged HAART therapy use continue. Although systemic viral load can be undetectable, the v...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/100008 http://hdl.handle.net/10220/16892 |
| _version_ | 1811690770568052736 |
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| author | Mahajan, Supriya D. Reynolds, Jessica L. Nair, Bindukumar B. Sykes, Donald E. Prasad, Paras N. Schwartz, Stanley A. Aalinkeel, Ravikumar Law, Wing-Cheung Yong, Ken-Tye Roy, Indrajit |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Mahajan, Supriya D. Reynolds, Jessica L. Nair, Bindukumar B. Sykes, Donald E. Prasad, Paras N. Schwartz, Stanley A. Aalinkeel, Ravikumar Law, Wing-Cheung Yong, Ken-Tye Roy, Indrajit |
| author_sort | Mahajan, Supriya D. |
| collection | NTU |
| description | The advent of highly active antiretroviral therapy (HAART) has significantly improved the prognosis for human immunodeficiency virus (HIV)-infected patients, however the adverse side effects associated with prolonged HAART therapy use continue. Although systemic viral load can be undetectable, the virus remains sequestered in anatomically privileged sites within the body. Nanotechnology-based delivery systems are being developed to target the virus within different tissue compartments and are being evaluated for their safety and efficacy. The current review outlines the various nanomaterials that are becoming increasingly used in biomedical applications by virtue of their robustness, safety, multimodality, and multifunctionality. Nanotechnology can revolutionize the field of HIV medicine by not only improving diagnosis, but also by improving delivery of antiretrovirals to targeted regions in the body and by significantly enhancing the efficacy of the currently available antiretroviral medications. |
| first_indexed | 2024-10-01T06:09:17Z |
| format | Journal Article |
| id | ntu-10356/100008 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:09:17Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/1000082022-02-16T16:31:03Z Anti-HIV-1 nanotherapeutics : promises and challenges for the future Mahajan, Supriya D. Reynolds, Jessica L. Nair, Bindukumar B. Sykes, Donald E. Prasad, Paras N. Schwartz, Stanley A. Aalinkeel, Ravikumar Law, Wing-Cheung Yong, Ken-Tye Roy, Indrajit School of Electrical and Electronic Engineering DRNTU::Engineering::Electrical and electronic engineering The advent of highly active antiretroviral therapy (HAART) has significantly improved the prognosis for human immunodeficiency virus (HIV)-infected patients, however the adverse side effects associated with prolonged HAART therapy use continue. Although systemic viral load can be undetectable, the virus remains sequestered in anatomically privileged sites within the body. Nanotechnology-based delivery systems are being developed to target the virus within different tissue compartments and are being evaluated for their safety and efficacy. The current review outlines the various nanomaterials that are becoming increasingly used in biomedical applications by virtue of their robustness, safety, multimodality, and multifunctionality. Nanotechnology can revolutionize the field of HIV medicine by not only improving diagnosis, but also by improving delivery of antiretrovirals to targeted regions in the body and by significantly enhancing the efficacy of the currently available antiretroviral medications. Published Version 2013-10-25T02:53:32Z 2019-12-06T20:14:58Z 2013-10-25T02:53:32Z 2019-12-06T20:14:58Z 2012 2012 Journal Article Mahajan S. D., Aalinkeel R., Law W.-C., Reynolds J. L., Nair B. B., Sykes D. E., et al. (2012). Anti-HIV-1 nanotherapeutics: promises and challenges for the future. International Journal of Nanomedicine, 7, 5301-5314. 1178-2013 https://hdl.handle.net/10356/100008 http://hdl.handle.net/10220/16892 10.2147/IJN.S25871 23055735 en International journal of nanomedicine © 2012 Mahajan et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. application/pdf |
| spellingShingle | DRNTU::Engineering::Electrical and electronic engineering Mahajan, Supriya D. Reynolds, Jessica L. Nair, Bindukumar B. Sykes, Donald E. Prasad, Paras N. Schwartz, Stanley A. Aalinkeel, Ravikumar Law, Wing-Cheung Yong, Ken-Tye Roy, Indrajit Anti-HIV-1 nanotherapeutics : promises and challenges for the future |
| title | Anti-HIV-1 nanotherapeutics : promises and challenges for the future |
| title_full | Anti-HIV-1 nanotherapeutics : promises and challenges for the future |
| title_fullStr | Anti-HIV-1 nanotherapeutics : promises and challenges for the future |
| title_full_unstemmed | Anti-HIV-1 nanotherapeutics : promises and challenges for the future |
| title_short | Anti-HIV-1 nanotherapeutics : promises and challenges for the future |
| title_sort | anti hiv 1 nanotherapeutics promises and challenges for the future |
| topic | DRNTU::Engineering::Electrical and electronic engineering |
| url | https://hdl.handle.net/10356/100008 http://hdl.handle.net/10220/16892 |
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