In vitro selection of mutant HDM2 resistant to nutlin inhibition
HDM2 binds to the p53 tumour suppressor and targets it for proteosomal degradation. Presently in clinical trials, the small molecule Nutlin-3A competitively binds to HDM2 and abrogates its repressive function. Using a novel in vitro selection methodology, we simulated the emergence of resistance by...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/100150 http://hdl.handle.net/10220/18644 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0062564 |