Hand-held volatilome analyzer based on elastically deformable nanofibers
This study reports on a hand-held volatilome analyzer for selective determination of clinically relevant biomarkers in exhaled breath. The sensing platform is based on electrospun polymer nanofiber-multiwalled carbon nanotube (MWCNT) sensing microchannels. Polymer nanofibers of poly(vinylidene fluor...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2019
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| Online Access: | https://hdl.handle.net/10356/100173 http://hdl.handle.net/10220/48551 |
| _version_ | 1826116533303115776 |
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| author | Yucel, Muge Akin, Osman Cayoren, Mehmet Akduman, Ibrahim Palaniappan, Alagappan Liedberg, Bo Hizal, Gurkan Inci, Fatih Yildiz, Umit Hakan |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Yucel, Muge Akin, Osman Cayoren, Mehmet Akduman, Ibrahim Palaniappan, Alagappan Liedberg, Bo Hizal, Gurkan Inci, Fatih Yildiz, Umit Hakan |
| author_sort | Yucel, Muge |
| collection | NTU |
| description | This study reports on a hand-held volatilome analyzer for selective determination of clinically relevant biomarkers in exhaled breath. The sensing platform is based on electrospun polymer nanofiber-multiwalled carbon nanotube (MWCNT) sensing microchannels. Polymer nanofibers of poly(vinylidene fluoride) (PVDF), polystyrene (PS), and poly(methyl methacrylate) (PMMA) incorporated with MWCNT exhibits a stable response to interferences of humidity and CO2 and provides selective deformations upon exposure of exhaled breath target volatilomes acetone and toluene, exhibiting correlation to diabetes and lung cancer, respectively. The sensing microchannels “P1” (PVDF-MWCNT), “P2” (PS-MWCNT), and “P3” (PMMA-MWCNT) are integrated with a microfluidic cartridge (μ-card) that facilitates collection and concentration of exhaled breath. The volatilome analyzer consists of a conductivity monitoring unit, signal conditioning circuitries and a low energy display module. A combinatorial operation algorithm was developed for analyzing normalized resistivity changes of the sensing microchannels upon exposure to breath in the concentration ranges between 35 ppb and 3.0 ppm for acetone and 1 ppb and 10 ppm for toluene. Subsequently, responses of volatilomes from individuals in the different risk groups of diabetes were evaluated for validation of the proposed methodology. We foresee that proposed methodology provides an avenue for rapid detection of volatilomes thereby enabling point of care diagnosis in high-risk group individuals. |
| first_indexed | 2024-10-01T04:12:57Z |
| format | Journal Article |
| id | ntu-10356/100173 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:12:57Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | ntu-10356/1001732023-07-14T15:53:04Z Hand-held volatilome analyzer based on elastically deformable nanofibers Yucel, Muge Akin, Osman Cayoren, Mehmet Akduman, Ibrahim Palaniappan, Alagappan Liedberg, Bo Hizal, Gurkan Inci, Fatih Yildiz, Umit Hakan School of Materials Science & Engineering Center for Biomimetic Sensor Science Volatilome Nanofibers DRNTU::Engineering::Materials This study reports on a hand-held volatilome analyzer for selective determination of clinically relevant biomarkers in exhaled breath. The sensing platform is based on electrospun polymer nanofiber-multiwalled carbon nanotube (MWCNT) sensing microchannels. Polymer nanofibers of poly(vinylidene fluoride) (PVDF), polystyrene (PS), and poly(methyl methacrylate) (PMMA) incorporated with MWCNT exhibits a stable response to interferences of humidity and CO2 and provides selective deformations upon exposure of exhaled breath target volatilomes acetone and toluene, exhibiting correlation to diabetes and lung cancer, respectively. The sensing microchannels “P1” (PVDF-MWCNT), “P2” (PS-MWCNT), and “P3” (PMMA-MWCNT) are integrated with a microfluidic cartridge (μ-card) that facilitates collection and concentration of exhaled breath. The volatilome analyzer consists of a conductivity monitoring unit, signal conditioning circuitries and a low energy display module. A combinatorial operation algorithm was developed for analyzing normalized resistivity changes of the sensing microchannels upon exposure to breath in the concentration ranges between 35 ppb and 3.0 ppm for acetone and 1 ppb and 10 ppm for toluene. Subsequently, responses of volatilomes from individuals in the different risk groups of diabetes were evaluated for validation of the proposed methodology. We foresee that proposed methodology provides an avenue for rapid detection of volatilomes thereby enabling point of care diagnosis in high-risk group individuals. Accepted version 2019-06-06T01:57:50Z 2019-12-06T20:17:50Z 2019-06-06T01:57:50Z 2019-12-06T20:17:50Z 2018 Journal Article Yucel, M., Akin, O., Cayoren, M., Akduman, I., Palaniappan, A., Liedberg, B., . . . & Yildiz, U. H. (2018). Hand-held volatilome analyzer based on elastically deformable nanofibers. Analytical Chemistry, 90(8), 5122-5129. doi:10.1021/acs.analchem.7b05187 0003-2700 https://hdl.handle.net/10356/100173 http://hdl.handle.net/10220/48551 10.1021/acs.analchem.7b05187 en Analytical Chemistry © 2018 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Analytical Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.analchem.7b05187 14 p. application/pdf |
| spellingShingle | Volatilome Nanofibers DRNTU::Engineering::Materials Yucel, Muge Akin, Osman Cayoren, Mehmet Akduman, Ibrahim Palaniappan, Alagappan Liedberg, Bo Hizal, Gurkan Inci, Fatih Yildiz, Umit Hakan Hand-held volatilome analyzer based on elastically deformable nanofibers |
| title | Hand-held volatilome analyzer based on elastically deformable nanofibers |
| title_full | Hand-held volatilome analyzer based on elastically deformable nanofibers |
| title_fullStr | Hand-held volatilome analyzer based on elastically deformable nanofibers |
| title_full_unstemmed | Hand-held volatilome analyzer based on elastically deformable nanofibers |
| title_short | Hand-held volatilome analyzer based on elastically deformable nanofibers |
| title_sort | hand held volatilome analyzer based on elastically deformable nanofibers |
| topic | Volatilome Nanofibers DRNTU::Engineering::Materials |
| url | https://hdl.handle.net/10356/100173 http://hdl.handle.net/10220/48551 |
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