Inhibition of the human respiratory syncytial virus small hydrophobic protein and structural variations in a bicelle environment
The small hydrophobic (SH) protein is a 64-amino-acid polypeptide encoded by the human respiratory syncytial virus (hRSV). SH protein has a single α-helical transmembrane (TM) domain that forms pentameric ion channels. Herein, we report the first inhibitor of the SH protein channel, pyronin B, and w...
Main Authors: | Li, Yan, To, Janet, Verdià-Baguena, Carmina, Dossena, Silvia, Surya, Wahyu, Huang, Mei, Paulmichi, Markus, Liu, Ding Xiang, Aguilella, Vicente M., Torres, Jaume |
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Other Authors: | School of Biological Sciences |
Format: | Journal Article |
Language: | English |
Published: |
2015
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/100387 http://hdl.handle.net/10220/25717 |
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