2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes
Here we demonstrate the applicability of 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for manipulating G-quadruplex folding by anti-position-favoring substitutions. A single guanine to 2′-F-ANA-guanine substitution can favor a single (3+1) hybrid conformation from a mixture of conformers....
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/100865 http://hdl.handle.net/10220/11049 |
| _version_ | 1811697222835765248 |
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| author | Lech, Christopher Jacques Li, Zhe Heddi, Brahim Phan, Anh Tuân |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Lech, Christopher Jacques Li, Zhe Heddi, Brahim Phan, Anh Tuân |
| author_sort | Lech, Christopher Jacques |
| collection | NTU |
| description | Here we demonstrate the applicability of 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for manipulating G-quadruplex folding by anti-position-favoring substitutions. A single guanine to 2′-F-ANA-guanine substitution can favor a single (3+1) hybrid conformation from a mixture of conformers. Rational substitutions of either type of 2′-F-modified nucleotide enable conformational switching from a (3+1) hybrid to a parallel folding topology. |
| first_indexed | 2024-10-01T07:51:50Z |
| format | Journal Article |
| id | ntu-10356/100865 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:51:50Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/1008652020-03-07T12:34:50Z 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes Lech, Christopher Jacques Li, Zhe Heddi, Brahim Phan, Anh Tuân School of Physical and Mathematical Sciences Here we demonstrate the applicability of 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for manipulating G-quadruplex folding by anti-position-favoring substitutions. A single guanine to 2′-F-ANA-guanine substitution can favor a single (3+1) hybrid conformation from a mixture of conformers. Rational substitutions of either type of 2′-F-modified nucleotide enable conformational switching from a (3+1) hybrid to a parallel folding topology. 2013-07-09T03:33:04Z 2019-12-06T20:29:30Z 2013-07-09T03:33:04Z 2019-12-06T20:29:30Z 2012 2012 Journal Article Lech, C. J., Li, Z., Heddi, B., & Phan, A. T. (2012). 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes. Chemical Communications, 48, 11425-11427. https://hdl.handle.net/10356/100865 http://hdl.handle.net/10220/11049 10.1039/c2cc35097a en Chemical communications © 2012 The Royal Society of Chemistry. |
| spellingShingle | Lech, Christopher Jacques Li, Zhe Heddi, Brahim Phan, Anh Tuân 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes |
| title | 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes |
| title_full | 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes |
| title_fullStr | 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes |
| title_full_unstemmed | 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes |
| title_short | 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes |
| title_sort | 2 f ana guanosine and 2 f guanosine as powerful tools for structural manipulation of g quadruplexes |
| url | https://hdl.handle.net/10356/100865 http://hdl.handle.net/10220/11049 |
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