2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes

Here we demonstrate the applicability of 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for manipulating G-quadruplex folding by anti-position-favoring substitutions. A single guanine to 2′-F-ANA-guanine substitution can favor a single (3+1) hybrid conformation from a mixture of conformers....

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Bibliographic Details
Main Authors: Lech, Christopher Jacques, Li, Zhe, Heddi, Brahim, Phan, Anh Tuân
Other Authors: School of Physical and Mathematical Sciences
Format: Journal Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/100865
http://hdl.handle.net/10220/11049

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