Rhodium-catalyzed C—H alkynylation of arenes at room temperature
The rhodium(III)-catalyzed ortho C[BOND]H alkynylation of non-electronically activated arenes is disclosed. This process features a straightforward and highly effective protocol for the synthesis of functionalized alkynes and represents the first example of merging a hypervalent iodine reagent with...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2014
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| Online Access: | https://hdl.handle.net/10356/100874 http://hdl.handle.net/10220/19640 |
| _version_ | 1826123955852804096 |
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| author | Feng, Chao Loh, Teck-Peng |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Feng, Chao Loh, Teck-Peng |
| author_sort | Feng, Chao |
| collection | NTU |
| description | The rhodium(III)-catalyzed ortho C[BOND]H alkynylation of non-electronically activated arenes is disclosed. This process features a straightforward and highly effective protocol for the synthesis of functionalized alkynes and represents the first example of merging a hypervalent iodine reagent with rhodium(III) catalysis. Notably, this reaction proceeds at room temperature, tolerates a variety of functional groups, and more importantly, exhibits high selectivity for monoalkynylation. |
| first_indexed | 2024-10-01T06:12:47Z |
| format | Journal Article |
| id | ntu-10356/100874 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:12:47Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/1008742020-03-07T12:34:50Z Rhodium-catalyzed C—H alkynylation of arenes at room temperature Feng, Chao Loh, Teck-Peng School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Organic chemistry The rhodium(III)-catalyzed ortho C[BOND]H alkynylation of non-electronically activated arenes is disclosed. This process features a straightforward and highly effective protocol for the synthesis of functionalized alkynes and represents the first example of merging a hypervalent iodine reagent with rhodium(III) catalysis. Notably, this reaction proceeds at room temperature, tolerates a variety of functional groups, and more importantly, exhibits high selectivity for monoalkynylation. 2014-06-10T08:30:39Z 2019-12-06T20:29:34Z 2014-06-10T08:30:39Z 2019-12-06T20:29:34Z 2014 2014 Journal Article Feng, C., & Loh, T.-P. (2014). Rhodium-Catalyzed C—H Alkynylation of Arenes at Room Temperature. Angewandte Chemie, 126(10), 2760-2764. 0044-8249 https://hdl.handle.net/10356/100874 http://hdl.handle.net/10220/19640 10.1002/ange.201309198 en Angewandte chemie © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| spellingShingle | DRNTU::Science::Chemistry::Organic chemistry Feng, Chao Loh, Teck-Peng Rhodium-catalyzed C—H alkynylation of arenes at room temperature |
| title | Rhodium-catalyzed C—H alkynylation of arenes at room temperature |
| title_full | Rhodium-catalyzed C—H alkynylation of arenes at room temperature |
| title_fullStr | Rhodium-catalyzed C—H alkynylation of arenes at room temperature |
| title_full_unstemmed | Rhodium-catalyzed C—H alkynylation of arenes at room temperature |
| title_short | Rhodium-catalyzed C—H alkynylation of arenes at room temperature |
| title_sort | rhodium catalyzed c h alkynylation of arenes at room temperature |
| topic | DRNTU::Science::Chemistry::Organic chemistry |
| url | https://hdl.handle.net/10356/100874 http://hdl.handle.net/10220/19640 |
| work_keys_str_mv | AT fengchao rhodiumcatalyzedchalkynylationofarenesatroomtemperature AT lohteckpeng rhodiumcatalyzedchalkynylationofarenesatroomtemperature |