RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors
RUNX family proteins are critical regulators of lineage differentiation during development. The high prevalence of RUNX mutation/epigenetic inactivation in human cancer indicates a causative role for dysfunctional RUNX in carcinogenesis. This is supported by well-documented evidence of functional in...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/101272 http://hdl.handle.net/10220/11093 |
| _version_ | 1811691313781800960 |
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| author | Chuang, Linda Shyue Huey Lai, Soak Kuan Murata-Hori, Maki Yamada, Ayumi Li, Hoi-Yeung Gunaratne, Jayantha Ito, Yoshiaki |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Chuang, Linda Shyue Huey Lai, Soak Kuan Murata-Hori, Maki Yamada, Ayumi Li, Hoi-Yeung Gunaratne, Jayantha Ito, Yoshiaki |
| author_sort | Chuang, Linda Shyue Huey |
| collection | NTU |
| description | RUNX family proteins are critical regulators of lineage differentiation during development. The high prevalence of RUNX mutation/epigenetic inactivation in human cancer indicates a causative role for dysfunctional RUNX in carcinogenesis. This is supported by well-documented evidence of functional interaction of RUNX with components of major oncogenic or tumor suppressive signaling pathways such as TGFβ and Wnt. Here, we explore the binding partners of RUNX3 proteins to further define the scope of RUNX3 function. Using a mass spectrometry-based approach, we found that RUNX3 binds to centrosomal protein rootletin. This led us to uncover the presence of RUNX proteins at the centrosome. Our findings suggest a potential function for RUNX3 during mitosis. |
| first_indexed | 2024-10-01T06:17:55Z |
| format | Journal Article |
| id | ntu-10356/101272 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:17:55Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/1012722020-03-07T12:18:15Z RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors Chuang, Linda Shyue Huey Lai, Soak Kuan Murata-Hori, Maki Yamada, Ayumi Li, Hoi-Yeung Gunaratne, Jayantha Ito, Yoshiaki School of Biological Sciences DRNTU::Science::Biological sciences RUNX family proteins are critical regulators of lineage differentiation during development. The high prevalence of RUNX mutation/epigenetic inactivation in human cancer indicates a causative role for dysfunctional RUNX in carcinogenesis. This is supported by well-documented evidence of functional interaction of RUNX with components of major oncogenic or tumor suppressive signaling pathways such as TGFβ and Wnt. Here, we explore the binding partners of RUNX3 proteins to further define the scope of RUNX3 function. Using a mass spectrometry-based approach, we found that RUNX3 binds to centrosomal protein rootletin. This led us to uncover the presence of RUNX proteins at the centrosome. Our findings suggest a potential function for RUNX3 during mitosis. 2013-07-10T03:48:00Z 2019-12-06T20:35:52Z 2013-07-10T03:48:00Z 2019-12-06T20:35:52Z 2012 2012 Journal Article Chuang, L. S. H., Lai, S. K., Murata-Hori, M., Yamada, A., Li, H.-Y., Gunaratne, J., et al. (2012). RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors. Cell Cycle, 11(10), 1938-1947. https://hdl.handle.net/10356/101272 http://hdl.handle.net/10220/11093 10.4161/cc.20278 en Cell cycle © 2012 Landes Bioscience. |
| spellingShingle | DRNTU::Science::Biological sciences Chuang, Linda Shyue Huey Lai, Soak Kuan Murata-Hori, Maki Yamada, Ayumi Li, Hoi-Yeung Gunaratne, Jayantha Ito, Yoshiaki RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors |
| title | RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors |
| title_full | RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors |
| title_fullStr | RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors |
| title_full_unstemmed | RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors |
| title_short | RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors |
| title_sort | runx3 interactome reveals novel centrosomal targeting of runx family of transcription factors |
| topic | DRNTU::Science::Biological sciences |
| url | https://hdl.handle.net/10356/101272 http://hdl.handle.net/10220/11093 |
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