Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines

Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines

As the only mammalian Argonaute protein capable of directly cleaving mRNAs in a small RNA-guided manner, Argonaute-2 (Ago2) is a keyplayer in RNA interference (RNAi) silencing via small interfering (si) or short hairpin (sh) RNAs. It is also a rate-limiting factor whose saturation by si/shRNAs limit...

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Bibliographic Details
Main Authors: Börner, Kathleen, Niopek, Dominik, Cotugno, Gabriella, Kaldenbach, Michaela, Pankert, Teresa, Willemsen, Joschka, Zhang, Xian, Schürmann, Nina, Streetz, Konrad, Kräusslich, Hans-Georg, Mockenhaupt, Stefan, Serva, Andrius, Grimm, Dirk, Hiet, Marie-Sophie, Wiedtke, Ellen, Binder, Marco, Castoldi, Mirco, Starkuviene, Vytaute, Erfle, Holger, Bartenschlager, Ralf, Boutros, Michael, Gilbert, Daniel F.
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2014
Subjects:
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/101612
http://hdl.handle.net/10220/18735

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