Functions and Regulation of Circular Dorsal Ruffles
Cells construct a number of plasma membrane structures to meet a range of physiological demands. Driven by juxtamembrane actin machinery, these actin-based membrane protrusions are essential for the operation and maintenance of cellular life. They are required for diverse cellular functions, such as...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/101817 http://hdl.handle.net/10220/11229 |
| _version_ | 1826111803753496576 |
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| author | Hoon, Jing-Ling. Wong, Wai-Keung. Koh, Cheng Gee |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Hoon, Jing-Ling. Wong, Wai-Keung. Koh, Cheng Gee |
| author_sort | Hoon, Jing-Ling. |
| collection | NTU |
| description | Cells construct a number of plasma membrane structures to meet a range of physiological demands. Driven by juxtamembrane actin machinery, these actin-based membrane protrusions are essential for the operation and maintenance of cellular life. They are required for diverse cellular functions, such as directed cell motility, cell spreading, adhesion, and substrate/matrix degradation. Circular dorsal ruffles (CDRs) are one class of such structures characterized as F-actin-rich membrane projections on the apical cell surface. CDRs commence their formation minutes after stimulation as flat, open, and immature ruffles and progressively develop into fully enclosed circular ruffles. These “rings” then mature and contract centrifugally before subsiding. Serving a critical function in receptor internalization and cell migration, CDRs are thus highly dynamic but transient formations. Here, we review the current state of knowledge concerning the regulation of circular dorsal ruffles. We focus specifically on the biochemical pathways leading to CDR formation in order to better define the roles and functions of these enigmatic structures. |
| first_indexed | 2024-10-01T02:56:29Z |
| format | Journal Article |
| id | ntu-10356/101817 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:56:29Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/1018172022-06-07T00:24:36Z Functions and Regulation of Circular Dorsal Ruffles Hoon, Jing-Ling. Wong, Wai-Keung. Koh, Cheng Gee School of Biological Sciences DRNTU::Science::Biological sciences::Molecular biology Cells construct a number of plasma membrane structures to meet a range of physiological demands. Driven by juxtamembrane actin machinery, these actin-based membrane protrusions are essential for the operation and maintenance of cellular life. They are required for diverse cellular functions, such as directed cell motility, cell spreading, adhesion, and substrate/matrix degradation. Circular dorsal ruffles (CDRs) are one class of such structures characterized as F-actin-rich membrane projections on the apical cell surface. CDRs commence their formation minutes after stimulation as flat, open, and immature ruffles and progressively develop into fully enclosed circular ruffles. These “rings” then mature and contract centrifugally before subsiding. Serving a critical function in receptor internalization and cell migration, CDRs are thus highly dynamic but transient formations. Here, we review the current state of knowledge concerning the regulation of circular dorsal ruffles. We focus specifically on the biochemical pathways leading to CDR formation in order to better define the roles and functions of these enigmatic structures. 2013-07-11T07:57:30Z 2019-12-06T20:44:56Z 2013-07-11T07:57:30Z 2019-12-06T20:44:56Z 2012 2012 Journal Article https://hdl.handle.net/10356/101817 http://hdl.handle.net/10220/11229 10.1128/MCB.00551-12 22927640 en Molecular and cellular biology © 2012 American Society for Microbiology. |
| spellingShingle | DRNTU::Science::Biological sciences::Molecular biology Hoon, Jing-Ling. Wong, Wai-Keung. Koh, Cheng Gee Functions and Regulation of Circular Dorsal Ruffles |
| title | Functions and Regulation of Circular Dorsal Ruffles |
| title_full | Functions and Regulation of Circular Dorsal Ruffles |
| title_fullStr | Functions and Regulation of Circular Dorsal Ruffles |
| title_full_unstemmed | Functions and Regulation of Circular Dorsal Ruffles |
| title_short | Functions and Regulation of Circular Dorsal Ruffles |
| title_sort | functions and regulation of circular dorsal ruffles |
| topic | DRNTU::Science::Biological sciences::Molecular biology |
| url | https://hdl.handle.net/10356/101817 http://hdl.handle.net/10220/11229 |
| work_keys_str_mv | AT hoonjingling functionsandregulationofcirculardorsalruffles AT wongwaikeung functionsandregulationofcirculardorsalruffles AT kohchenggee functionsandregulationofcirculardorsalruffles |