Mass transport for mixed co-culture applications in a perfusion bioreactor partially filled with a porous layer
A simplified analysis is carried out to derive the analytical solution of the mass transfer equation in a microchannel bioreactor, which has a porous wall for the co-culture of two types of cells distributed randomly and uniformly. Based on the analysis, a group of dimensionless parameters is propos...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/101894 http://hdl.handle.net/10220/19814 |
| _version_ | 1826117645995343872 |
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| author | Bai, H. X. Yu, Peng Zeng, Y. Winoto, Sonny H. Low, Hong-Tong |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Bai, H. X. Yu, Peng Zeng, Y. Winoto, Sonny H. Low, Hong-Tong |
| author_sort | Bai, H. X. |
| collection | NTU |
| description | A simplified analysis is carried out to derive the analytical solution of the mass transfer equation in a microchannel bioreactor, which has a porous wall for the co-culture of two types of cells distributed randomly and uniformly. Based on the analysis, a group of dimensionless parameters is proposed, which can be applied to correlate the numerical data and characterize the mass transfer in the bioreactor. The normalized numerical data, for the concentration at the porous-fluid interface and concentration difference between the interface and the base, show satisfactory correlation when presented as a function of the effective distance parameter. Two cell culture examples are presented to demonstrate the general applications of the correlated results in the design of a co-culture microchannel bioreactor with a porous wall. |
| first_indexed | 2024-10-01T04:30:42Z |
| format | Journal Article |
| id | ntu-10356/101894 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:30:42Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/1018942020-03-07T13:22:21Z Mass transport for mixed co-culture applications in a perfusion bioreactor partially filled with a porous layer Bai, H. X. Yu, Peng Zeng, Y. Winoto, Sonny H. Low, Hong-Tong School of Mechanical and Aerospace Engineering DRNTU::Engineering::Mechanical engineering A simplified analysis is carried out to derive the analytical solution of the mass transfer equation in a microchannel bioreactor, which has a porous wall for the co-culture of two types of cells distributed randomly and uniformly. Based on the analysis, a group of dimensionless parameters is proposed, which can be applied to correlate the numerical data and characterize the mass transfer in the bioreactor. The normalized numerical data, for the concentration at the porous-fluid interface and concentration difference between the interface and the base, show satisfactory correlation when presented as a function of the effective distance parameter. Two cell culture examples are presented to demonstrate the general applications of the correlated results in the design of a co-culture microchannel bioreactor with a porous wall. 2014-06-19T02:02:16Z 2019-12-06T20:46:24Z 2014-06-19T02:02:16Z 2019-12-06T20:46:24Z 2014 2014 Journal Article Bai, H. X., Yu, P., Zeng, Y., Winoto, S. H., & Low, H.-T. (2014). MASS TRANSPORT FOR MIXED CO-CULTURE APPLICATIONS IN A PERFUSION BIOREACTOR PARTIALLY FILLED WITH A POROUS LAYER. Journal of Porous Media, 17(1), 17-30. 1091-028X https://hdl.handle.net/10356/101894 http://hdl.handle.net/10220/19814 10.1615/JPorMedia.v17.i1.20 en Journal of porous media © 2014 Begell House. |
| spellingShingle | DRNTU::Engineering::Mechanical engineering Bai, H. X. Yu, Peng Zeng, Y. Winoto, Sonny H. Low, Hong-Tong Mass transport for mixed co-culture applications in a perfusion bioreactor partially filled with a porous layer |
| title | Mass transport for mixed co-culture applications in a perfusion bioreactor partially filled with a porous layer |
| title_full | Mass transport for mixed co-culture applications in a perfusion bioreactor partially filled with a porous layer |
| title_fullStr | Mass transport for mixed co-culture applications in a perfusion bioreactor partially filled with a porous layer |
| title_full_unstemmed | Mass transport for mixed co-culture applications in a perfusion bioreactor partially filled with a porous layer |
| title_short | Mass transport for mixed co-culture applications in a perfusion bioreactor partially filled with a porous layer |
| title_sort | mass transport for mixed co culture applications in a perfusion bioreactor partially filled with a porous layer |
| topic | DRNTU::Engineering::Mechanical engineering |
| url | https://hdl.handle.net/10356/101894 http://hdl.handle.net/10220/19814 |
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