Towards sustainability : new approaches to nano-drug preparation
The conversion of drugs into drug nanoparticles (nano-drugs) represents a feasible method to enhance bioavailability of otherwise sparingly soluble-drugs. Nano-drugs enhance bioavailability through the improvement of dissolution rate and saturation solubility of drugs, by virtue of their small sizes...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2014
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| Online Access: | https://hdl.handle.net/10356/101907 http://hdl.handle.net/10220/19825 |
| _version_ | 1826109712450453504 |
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| author | Cheow, Wean Sin Xu, Rong Hadinoto, Kunn |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Cheow, Wean Sin Xu, Rong Hadinoto, Kunn |
| author_sort | Cheow, Wean Sin |
| collection | NTU |
| description | The conversion of drugs into drug nanoparticles (nano-drugs) represents a feasible method to enhance bioavailability of otherwise sparingly soluble-drugs. Nano-drugs enhance bioavailability through the improvement of dissolution rate and saturation solubility of drugs, by virtue of their small sizes. Nano-drugs available in the market are usually produced by top-down methods, such as wet milling and high pressure homogenization. These conventional top-down methods, however, suffer from high energy and time requirement, as well as wide and inconsistent nano-drug size distribution. Furthermore, commercially available nano-drugs are predominantly crystalline while amorphous nano-drugs are largely neglected despite their propensity to generate high saturation solubility. In this review, nonconventional methods to prepare crystalline and amorphous nano-drugs are discussed, with the bioavailability enhancing characteristics highlighted. Both top-down and bottom-up methods are covered, finally, a sustainability-based perspective comparing amorphous and crystalline nano-drugs is presented. |
| first_indexed | 2024-10-01T02:22:46Z |
| format | Journal Article |
| id | ntu-10356/101907 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:22:46Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/1019072020-03-07T11:40:23Z Towards sustainability : new approaches to nano-drug preparation Cheow, Wean Sin Xu, Rong Hadinoto, Kunn School of Chemical and Biomedical Engineering DRNTU::Engineering::Chemical engineering The conversion of drugs into drug nanoparticles (nano-drugs) represents a feasible method to enhance bioavailability of otherwise sparingly soluble-drugs. Nano-drugs enhance bioavailability through the improvement of dissolution rate and saturation solubility of drugs, by virtue of their small sizes. Nano-drugs available in the market are usually produced by top-down methods, such as wet milling and high pressure homogenization. These conventional top-down methods, however, suffer from high energy and time requirement, as well as wide and inconsistent nano-drug size distribution. Furthermore, commercially available nano-drugs are predominantly crystalline while amorphous nano-drugs are largely neglected despite their propensity to generate high saturation solubility. In this review, nonconventional methods to prepare crystalline and amorphous nano-drugs are discussed, with the bioavailability enhancing characteristics highlighted. Both top-down and bottom-up methods are covered, finally, a sustainability-based perspective comparing amorphous and crystalline nano-drugs is presented. 2014-06-19T03:48:38Z 2019-12-06T20:46:31Z 2014-06-19T03:48:38Z 2019-12-06T20:46:31Z 2013 2013 Journal Article Cheow, W. S., Xu, R., & Hadinoto, K. (2013). Towards Sustainability: New Approaches to Nano-Drug Preparation. Current Pharmaceutical Design, 19(35), 6229-6245. 1381-6128 https://hdl.handle.net/10356/101907 http://hdl.handle.net/10220/19825 10.2174/1381612811319350002 en Current pharmaceutical design © 2013 Bentham Science Publishers. |
| spellingShingle | DRNTU::Engineering::Chemical engineering Cheow, Wean Sin Xu, Rong Hadinoto, Kunn Towards sustainability : new approaches to nano-drug preparation |
| title | Towards sustainability : new approaches to nano-drug preparation |
| title_full | Towards sustainability : new approaches to nano-drug preparation |
| title_fullStr | Towards sustainability : new approaches to nano-drug preparation |
| title_full_unstemmed | Towards sustainability : new approaches to nano-drug preparation |
| title_short | Towards sustainability : new approaches to nano-drug preparation |
| title_sort | towards sustainability new approaches to nano drug preparation |
| topic | DRNTU::Engineering::Chemical engineering |
| url | https://hdl.handle.net/10356/101907 http://hdl.handle.net/10220/19825 |
| work_keys_str_mv | AT cheowweansin towardssustainabilitynewapproachestonanodrugpreparation AT xurong towardssustainabilitynewapproachestonanodrugpreparation AT hadinotokunn towardssustainabilitynewapproachestonanodrugpreparation |