Apelin inhibits adipogenesis and lipolysis through distint molecular pathways
Apelin is an adipokine secreted by adipocytes. Co-expression of apelin and apelin receptor (APJ) in adipocytes implies the autocrine regulations of apelin on adipocyte functions through yet unknown molecular mechanisms. In the present study, we provide evidence that apelin, through its interaction w...
| Príomhchruthaitheoirí: | , , , , , , , |
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| Rannpháirtithe: | |
| Formáid: | Journal Article |
| Teanga: | English |
| Foilsithe / Cruthaithe: |
2013
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| Rochtain ar líne: | https://hdl.handle.net/10356/101915 http://hdl.handle.net/10220/11157 |
| _version_ | 1826128061902356480 |
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| author | Than, Aung Cheng, Yiqi Foh, Li-Chern Leow, Melvin Khee-Shing Lim, Su Chi Chuah, Yon Jin Kang, Yuejun Chen, Peng |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Than, Aung Cheng, Yiqi Foh, Li-Chern Leow, Melvin Khee-Shing Lim, Su Chi Chuah, Yon Jin Kang, Yuejun Chen, Peng |
| author_sort | Than, Aung |
| collection | NTU |
| description | Apelin is an adipokine secreted by adipocytes. Co-expression of apelin and apelin receptor (APJ) in adipocytes implies the autocrine regulations of apelin on adipocyte functions through yet unknown molecular mechanisms. In the present study, we provide evidence that apelin, through its interaction with APJ receptor, inhibits adipogenesis of pre-adipocytes and lipolysis in mature adipocytes. The detailed molecular pathways underlying apelin signaling is proposed based on our experimental observations. Specifically, we show that apelin suppresses adipogenesis through MAPK kinase/ERK dependent pathways. And by preventing lipid droplet fragmentation, apelin inhibits basal lipolysis through AMP kinase dependent enhancement of perilipin expression and inhibits hormone-stimulated acute lipolysis through decreasing perilipin phosphorylation. Apelin induced decrease of free fatty acid release can be attributed to its dual inhibition on adipogenesis and lipolysis. This study suggests that the autocrine signaling of apelin may serve as a novel therapeutic target for obesity and other metabolic disorders. |
| first_indexed | 2024-10-01T07:18:44Z |
| format | Journal Article |
| id | ntu-10356/101915 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:18:44Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/1019152020-03-07T11:40:23Z Apelin inhibits adipogenesis and lipolysis through distint molecular pathways Than, Aung Cheng, Yiqi Foh, Li-Chern Leow, Melvin Khee-Shing Lim, Su Chi Chuah, Yon Jin Kang, Yuejun Chen, Peng School of Chemical and Biomedical Engineering Apelin is an adipokine secreted by adipocytes. Co-expression of apelin and apelin receptor (APJ) in adipocytes implies the autocrine regulations of apelin on adipocyte functions through yet unknown molecular mechanisms. In the present study, we provide evidence that apelin, through its interaction with APJ receptor, inhibits adipogenesis of pre-adipocytes and lipolysis in mature adipocytes. The detailed molecular pathways underlying apelin signaling is proposed based on our experimental observations. Specifically, we show that apelin suppresses adipogenesis through MAPK kinase/ERK dependent pathways. And by preventing lipid droplet fragmentation, apelin inhibits basal lipolysis through AMP kinase dependent enhancement of perilipin expression and inhibits hormone-stimulated acute lipolysis through decreasing perilipin phosphorylation. Apelin induced decrease of free fatty acid release can be attributed to its dual inhibition on adipogenesis and lipolysis. This study suggests that the autocrine signaling of apelin may serve as a novel therapeutic target for obesity and other metabolic disorders. 2013-07-11T02:11:01Z 2019-12-06T20:46:36Z 2013-07-11T02:11:01Z 2019-12-06T20:46:36Z 2012 2012 Journal Article Than, A., Cheng, Y., Foh, L.-C., Leow, M. K.-S., Lim, S. C., Chuah, Y. J., et al. (2012). Apelin inhibits adipogenesis and lipolysis through distint molecular pathways. Molecular and Cellular Endocrinology, 362(1-2), 227-241. https://hdl.handle.net/10356/101915 http://hdl.handle.net/10220/11157 10.1016/j.mce.2012.07.002 en Molecular and cellular endocrinology © 2012 Elsevier Ireland Ltd. |
| spellingShingle | Than, Aung Cheng, Yiqi Foh, Li-Chern Leow, Melvin Khee-Shing Lim, Su Chi Chuah, Yon Jin Kang, Yuejun Chen, Peng Apelin inhibits adipogenesis and lipolysis through distint molecular pathways |
| title | Apelin inhibits adipogenesis and lipolysis through distint molecular pathways |
| title_full | Apelin inhibits adipogenesis and lipolysis through distint molecular pathways |
| title_fullStr | Apelin inhibits adipogenesis and lipolysis through distint molecular pathways |
| title_full_unstemmed | Apelin inhibits adipogenesis and lipolysis through distint molecular pathways |
| title_short | Apelin inhibits adipogenesis and lipolysis through distint molecular pathways |
| title_sort | apelin inhibits adipogenesis and lipolysis through distint molecular pathways |
| url | https://hdl.handle.net/10356/101915 http://hdl.handle.net/10220/11157 |
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