Apelin secretion and expression of apelin receptors in 3T3-L1 adipocytes are differentially regulated by angiotensin type 1 and type 2 receptors
Adipocytes play pivotal roles in regulating metabolism through secretion of a variety of adipokines, which in turn is regulated by other metabolic factors (e.g., insulin). Understanding the regulations of adipokine secretion is important because adipokines are implicated with metabolic disorders, su...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/101996 http://hdl.handle.net/10220/11154 |
| _version_ | 1811676458150526976 |
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| author | Than, Aung Tee, Wei Teng Chen, Peng |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Than, Aung Tee, Wei Teng Chen, Peng |
| author_sort | Than, Aung |
| collection | NTU |
| description | Adipocytes play pivotal roles in regulating metabolism through secretion of a variety of adipokines, which in turn is regulated by other metabolic factors (e.g., insulin). Understanding the regulations of adipokine secretion is important because adipokines are implicated with metabolic disorders, such as, obesity and diabetes mellitus. Here, we investigated the regulatory roles of angiotensin II (AngII) on the secretion of apelin in 3T3-L1 adipocytes, and distinct signaling pathways mediated by AngII receptor type 1 (AT1) and type 2 (AT2) were revealed. It was found that activation of AT1 receptors stimulates apelin secretion in Ca2+, protein kinase C, and MAPK kinase dependent ways while activation of AT2 receptors inhibits apelin secretion through cAMP and cGMP dependent pathways. Furthermore, we demonstrate that the expression of apelin receptor (APJ) is also similarly regulated by AT1 and AT2 receptors. Finally, a detailed AngII signaling map is proposed. |
| first_indexed | 2024-10-01T02:21:47Z |
| format | Journal Article |
| id | ntu-10356/101996 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:21:47Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/1019962020-03-07T11:40:23Z Apelin secretion and expression of apelin receptors in 3T3-L1 adipocytes are differentially regulated by angiotensin type 1 and type 2 receptors Than, Aung Tee, Wei Teng Chen, Peng School of Chemical and Biomedical Engineering Adipocytes play pivotal roles in regulating metabolism through secretion of a variety of adipokines, which in turn is regulated by other metabolic factors (e.g., insulin). Understanding the regulations of adipokine secretion is important because adipokines are implicated with metabolic disorders, such as, obesity and diabetes mellitus. Here, we investigated the regulatory roles of angiotensin II (AngII) on the secretion of apelin in 3T3-L1 adipocytes, and distinct signaling pathways mediated by AngII receptor type 1 (AT1) and type 2 (AT2) were revealed. It was found that activation of AT1 receptors stimulates apelin secretion in Ca2+, protein kinase C, and MAPK kinase dependent ways while activation of AT2 receptors inhibits apelin secretion through cAMP and cGMP dependent pathways. Furthermore, we demonstrate that the expression of apelin receptor (APJ) is also similarly regulated by AT1 and AT2 receptors. Finally, a detailed AngII signaling map is proposed. 2013-07-11T01:58:30Z 2019-12-06T20:48:08Z 2013-07-11T01:58:30Z 2019-12-06T20:48:08Z 2012 2012 Journal Article Than, A., Tee, W. T., Chen, P. (2012). Apelin secretion and expression of apelin receptors in 3T3-L1 adipocytes are differentially regulated by angiotensin type 1 and type 2 receptors. Molecular and Cellular Endocrinology, 351(2), 296-305. https://hdl.handle.net/10356/101996 http://hdl.handle.net/10220/11154 10.1016/j.mce.2012.01.005 en Molecular and cellular endocrinology © 2012 Elsevier Ireland Ltd. |
| spellingShingle | Than, Aung Tee, Wei Teng Chen, Peng Apelin secretion and expression of apelin receptors in 3T3-L1 adipocytes are differentially regulated by angiotensin type 1 and type 2 receptors |
| title | Apelin secretion and expression of apelin receptors in 3T3-L1 adipocytes are differentially regulated by angiotensin type 1 and type 2 receptors |
| title_full | Apelin secretion and expression of apelin receptors in 3T3-L1 adipocytes are differentially regulated by angiotensin type 1 and type 2 receptors |
| title_fullStr | Apelin secretion and expression of apelin receptors in 3T3-L1 adipocytes are differentially regulated by angiotensin type 1 and type 2 receptors |
| title_full_unstemmed | Apelin secretion and expression of apelin receptors in 3T3-L1 adipocytes are differentially regulated by angiotensin type 1 and type 2 receptors |
| title_short | Apelin secretion and expression of apelin receptors in 3T3-L1 adipocytes are differentially regulated by angiotensin type 1 and type 2 receptors |
| title_sort | apelin secretion and expression of apelin receptors in 3t3 l1 adipocytes are differentially regulated by angiotensin type 1 and type 2 receptors |
| url | https://hdl.handle.net/10356/101996 http://hdl.handle.net/10220/11154 |
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