High framerate photoacoustic imaging of blood clots
Deep vein thrombosis (DVT) is a disorder that occurs when a blood clot (thrombus) forms in one or more of the deep veins in your body, usually in your legs. Deep vein thrombosis can cause leg pain or swelling, but also can occur with no symptoms. If the clot moves to the vital organs like lungs, hea...
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| Format: | Conference Paper |
| Language: | English |
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2019
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| Online Access: | https://hdl.handle.net/10356/102638 http://hdl.handle.net/10220/49466 |
| _version_ | 1811689470890606592 |
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| author | Sivasubramanian, Kathyayini Das, Dhiman Pramanik, Manojit |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Sivasubramanian, Kathyayini Das, Dhiman Pramanik, Manojit |
| author_sort | Sivasubramanian, Kathyayini |
| collection | NTU |
| description | Deep vein thrombosis (DVT) is a disorder that occurs when a blood clot (thrombus) forms in one or more of the deep veins in your body, usually in your legs. Deep vein thrombosis can cause leg pain or swelling, but also can occur with no symptoms. If the clot moves to the vital organs like lungs, heart, brain etc., it can be very fatal and can cause death to the individual. Diagnosing it at early stages is very crucial to decide the treatment strategy. The most commonly used techniques that are used for the diagnosis includes ultrasound, x-ray, CT, etc. For definitive diagnosis contrast agents are required for better visualization of the blood clots and harmful radiations are used. For label free imaging of the blood clots, photoacoustic imaging can be used. To perform in-vivo photoacoustic imaging, high framerate imaging is needed as the velocity of the blood in the veins is between 3 cm/s to 14 cm/s. In this work, we have shown high framerate photoacoustic imaging at different framerates of 5, 10, 50, 100, 500, 1000, 2000 and 3000 fps using a pulsed laser diode of 7000 Hz frequency. We have demonstrated label free imaging of blood clots at 803 nm. Blood clot has at least 1.5 times higher SNR compared to blood and can be clearly visualized against blood as background. High framerate photoacoustic imaging can be used for label free diagnosis of deep vein thrombosis. |
| first_indexed | 2024-10-01T05:48:37Z |
| format | Conference Paper |
| id | ntu-10356/102638 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:48:37Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | ntu-10356/1026382023-12-29T06:44:07Z High framerate photoacoustic imaging of blood clots Sivasubramanian, Kathyayini Das, Dhiman Pramanik, Manojit School of Chemical and Biomedical Engineering Proceedings of SPIE - Photons Plus Ultrasound: Imaging and Sensing 2019 Clinical Imaging System Engineering::Chemical engineering Photoacoustic Imaging Deep vein thrombosis (DVT) is a disorder that occurs when a blood clot (thrombus) forms in one or more of the deep veins in your body, usually in your legs. Deep vein thrombosis can cause leg pain or swelling, but also can occur with no symptoms. If the clot moves to the vital organs like lungs, heart, brain etc., it can be very fatal and can cause death to the individual. Diagnosing it at early stages is very crucial to decide the treatment strategy. The most commonly used techniques that are used for the diagnosis includes ultrasound, x-ray, CT, etc. For definitive diagnosis contrast agents are required for better visualization of the blood clots and harmful radiations are used. For label free imaging of the blood clots, photoacoustic imaging can be used. To perform in-vivo photoacoustic imaging, high framerate imaging is needed as the velocity of the blood in the veins is between 3 cm/s to 14 cm/s. In this work, we have shown high framerate photoacoustic imaging at different framerates of 5, 10, 50, 100, 500, 1000, 2000 and 3000 fps using a pulsed laser diode of 7000 Hz frequency. We have demonstrated label free imaging of blood clots at 803 nm. Blood clot has at least 1.5 times higher SNR compared to blood and can be clearly visualized against blood as background. High framerate photoacoustic imaging can be used for label free diagnosis of deep vein thrombosis. MOE (Min. of Education, S’pore) Accepted version 2019-07-25T02:11:46Z 2019-12-06T20:58:03Z 2019-07-25T02:11:46Z 2019-12-06T20:58:03Z 2019-03-01 2019 Conference Paper Sivasubramanian, K., Das, D., & Pramanik, M. (2019). High framerate photoacoustic imaging of blood clots. Proceedings of SPIE - Photons Plus Ultrasound: Imaging and Sensing 2019. https://hdl.handle.net/10356/102638 http://hdl.handle.net/10220/49466 209752 en © 2019 Society of Photo-optical Instrumentation Engineers (SPIE). All rights reserved. This paper was published in Proceedings of SPIE - Photons Plus Ultrasound: Imaging and Sensing 2019 and is made available with permission of Society of Photo-optical Instrumentation Engineers (SPIE). 6 p. application/pdf |
| spellingShingle | Clinical Imaging System Engineering::Chemical engineering Photoacoustic Imaging Sivasubramanian, Kathyayini Das, Dhiman Pramanik, Manojit High framerate photoacoustic imaging of blood clots |
| title | High framerate photoacoustic imaging of blood clots |
| title_full | High framerate photoacoustic imaging of blood clots |
| title_fullStr | High framerate photoacoustic imaging of blood clots |
| title_full_unstemmed | High framerate photoacoustic imaging of blood clots |
| title_short | High framerate photoacoustic imaging of blood clots |
| title_sort | high framerate photoacoustic imaging of blood clots |
| topic | Clinical Imaging System Engineering::Chemical engineering Photoacoustic Imaging |
| url | https://hdl.handle.net/10356/102638 http://hdl.handle.net/10220/49466 |
| work_keys_str_mv | AT sivasubramaniankathyayini highframeratephotoacousticimagingofbloodclots AT dasdhiman highframeratephotoacousticimagingofbloodclots AT pramanikmanojit highframeratephotoacousticimagingofbloodclots |