Peramivir and laninamivir susceptibility of circulating influenza A and B viruses
Influenza viruses collected from regions of Asia, Africa and Oceania between 2009 and 2012 were tested for their susceptibility to two new neuraminidase inhibitors, peramivir and laninamivir. All viruses tested had normal laninamivir inhibition. However, 3·2% (19/599) of A(H1N1)pdm09 viruses had hig...
| Main Authors: | , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2014
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/102809 http://hdl.handle.net/10220/19127 |
| _version_ | 1826124818464899072 |
|---|---|
| author | Leang, Sook-Kwan Kwok, Simon Sullivan, Sheena G. Maurer-Stroh, Sebastian Kelso, Anne Barr, Ian G. Hurt, Aeron C. |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Leang, Sook-Kwan Kwok, Simon Sullivan, Sheena G. Maurer-Stroh, Sebastian Kelso, Anne Barr, Ian G. Hurt, Aeron C. |
| author_sort | Leang, Sook-Kwan |
| collection | NTU |
| description | Influenza viruses collected from regions of Asia, Africa and Oceania between 2009 and 2012 were tested for their susceptibility to two new neuraminidase inhibitors, peramivir and laninamivir. All viruses tested had normal laninamivir inhibition. However, 3·2% (19/599) of A(H1N1)pdm09 viruses had highly reduced peramivir inhibition (due to H275Y NA mutation) and <1% (6/1238) of influenza B viruses had reduced or highly reduced peramivir inhibition, with single occurrence of variants containing I221T, A245T, K360E, A395E, D432G and a combined G145R+Y142H mutation. These data demonstrate that despite an increase in H275Y variants in 2011, there was no marked change in the frequency of peramivir- or laninamivir-resistant variants following the market release of the drugs in Japan in 2010. |
| first_indexed | 2024-10-01T06:26:34Z |
| format | Journal Article |
| id | ntu-10356/102809 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:26:34Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/1028092023-02-28T17:05:31Z Peramivir and laninamivir susceptibility of circulating influenza A and B viruses Leang, Sook-Kwan Kwok, Simon Sullivan, Sheena G. Maurer-Stroh, Sebastian Kelso, Anne Barr, Ian G. Hurt, Aeron C. School of Biological Sciences DRNTU::Science::Biological sciences::Microbiology::Virology Influenza viruses collected from regions of Asia, Africa and Oceania between 2009 and 2012 were tested for their susceptibility to two new neuraminidase inhibitors, peramivir and laninamivir. All viruses tested had normal laninamivir inhibition. However, 3·2% (19/599) of A(H1N1)pdm09 viruses had highly reduced peramivir inhibition (due to H275Y NA mutation) and <1% (6/1238) of influenza B viruses had reduced or highly reduced peramivir inhibition, with single occurrence of variants containing I221T, A245T, K360E, A395E, D432G and a combined G145R+Y142H mutation. These data demonstrate that despite an increase in H275Y variants in 2011, there was no marked change in the frequency of peramivir- or laninamivir-resistant variants following the market release of the drugs in Japan in 2010. Published version 2014-04-04T07:50:50Z 2019-12-06T21:00:35Z 2014-04-04T07:50:50Z 2019-12-06T21:00:35Z 2013 2013 Journal Article Leang, S.-K., Kwok, S., Sullivan, S. G., Maurer-Stroh, S., Kelso, A., Barr, I. G., et al. (2014). Peramivir and laninamivir susceptibility of circulating influenza A and B viruses. Influenza and Other Respiratory Viruses, 8(2), 135-139. 1750-2640 https://hdl.handle.net/10356/102809 http://hdl.handle.net/10220/19127 10.1111/irv.12187 24734292 en Influenza and other respiratory viruses © 2013 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences::Microbiology::Virology Leang, Sook-Kwan Kwok, Simon Sullivan, Sheena G. Maurer-Stroh, Sebastian Kelso, Anne Barr, Ian G. Hurt, Aeron C. Peramivir and laninamivir susceptibility of circulating influenza A and B viruses |
| title | Peramivir and laninamivir susceptibility of circulating influenza A and B viruses |
| title_full | Peramivir and laninamivir susceptibility of circulating influenza A and B viruses |
| title_fullStr | Peramivir and laninamivir susceptibility of circulating influenza A and B viruses |
| title_full_unstemmed | Peramivir and laninamivir susceptibility of circulating influenza A and B viruses |
| title_short | Peramivir and laninamivir susceptibility of circulating influenza A and B viruses |
| title_sort | peramivir and laninamivir susceptibility of circulating influenza a and b viruses |
| topic | DRNTU::Science::Biological sciences::Microbiology::Virology |
| url | https://hdl.handle.net/10356/102809 http://hdl.handle.net/10220/19127 |
| work_keys_str_mv | AT leangsookkwan peramivirandlaninamivirsusceptibilityofcirculatinginfluenzaaandbviruses AT kwoksimon peramivirandlaninamivirsusceptibilityofcirculatinginfluenzaaandbviruses AT sullivansheenag peramivirandlaninamivirsusceptibilityofcirculatinginfluenzaaandbviruses AT maurerstrohsebastian peramivirandlaninamivirsusceptibilityofcirculatinginfluenzaaandbviruses AT kelsoanne peramivirandlaninamivirsusceptibilityofcirculatinginfluenzaaandbviruses AT barriang peramivirandlaninamivirsusceptibilityofcirculatinginfluenzaaandbviruses AT hurtaeronc peramivirandlaninamivirsusceptibilityofcirculatinginfluenzaaandbviruses |