Hyaluronic acid-based nanocomposite hydrogels for ocular drug delivery applications
Hyaluronic acid (HA) is a widely investigated biomaterial for many therapeutic applications owing to its unique properties of biocompatibility, biodegradation, and viscoelasticity. HA being a natural component of eye tissue with significant role in wound healing is a natural choice as a carrier for...
| Main Authors: | , , , , , |
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| 格式: | Journal Article |
| 语言: | English |
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2014
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| 在线阅读: | https://hdl.handle.net/10356/102812 http://hdl.handle.net/10220/19063 |
| _version_ | 1826127198505926656 |
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| author | Widjaja, Leonardus Kresna Bora, Meghali Chan, Paul Ng Poh Huat Lipik, Vitali Wong, Tina T. L. Venkatraman, Subbu S. |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Widjaja, Leonardus Kresna Bora, Meghali Chan, Paul Ng Poh Huat Lipik, Vitali Wong, Tina T. L. Venkatraman, Subbu S. |
| author_sort | Widjaja, Leonardus Kresna |
| collection | NTU |
| description | Hyaluronic acid (HA) is a widely investigated biomaterial for many therapeutic applications owing to its unique properties of biocompatibility, biodegradation, and viscoelasticity. HA being a natural component of eye tissue with significant role in wound healing is a natural choice as a carrier for ocular drug delivery, provided the incorporated drugs are released in a sustained manner. However, localized sustained release of drugs inside eye has been difficult to achieve because of the inability to retain carriers for long periods in the eye. Using noncrosslinked (soluble) HA offers limited control over site retention of drugs. In order to obtain prolonged sustained delivery, two HA-based composite hydrogels incorporating nanocarriers, have been synthesized and characterized for swelling, rheology, degradation, and in vitro release of latanoprost, a drug used to reduce intraocular pressure. The HA is first chemically modified, mixed with drug-loaded liposomes, and then crosslinked to obtain nanocomposite hydrogels. In vitro release study shows longer sustained release of latanoprost from composite hydrogels as compared to liposomes or hydrogels alone indicating additional resistance to drug diffusion because of the incorporation of liposomes inside the hydrogels. It is believed that these nanocomposite hydrogels, with controlled degradation properties and sustained release, could serve as potential drug delivery systems for many ocular diseases. |
| first_indexed | 2024-10-01T07:04:52Z |
| format | Journal Article |
| id | ntu-10356/102812 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:04:52Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/1028122020-06-01T10:13:43Z Hyaluronic acid-based nanocomposite hydrogels for ocular drug delivery applications Widjaja, Leonardus Kresna Bora, Meghali Chan, Paul Ng Poh Huat Lipik, Vitali Wong, Tina T. L. Venkatraman, Subbu S. School of Materials Science & Engineering DRNTU::Engineering::Materials::Biomaterials Hyaluronic acid (HA) is a widely investigated biomaterial for many therapeutic applications owing to its unique properties of biocompatibility, biodegradation, and viscoelasticity. HA being a natural component of eye tissue with significant role in wound healing is a natural choice as a carrier for ocular drug delivery, provided the incorporated drugs are released in a sustained manner. However, localized sustained release of drugs inside eye has been difficult to achieve because of the inability to retain carriers for long periods in the eye. Using noncrosslinked (soluble) HA offers limited control over site retention of drugs. In order to obtain prolonged sustained delivery, two HA-based composite hydrogels incorporating nanocarriers, have been synthesized and characterized for swelling, rheology, degradation, and in vitro release of latanoprost, a drug used to reduce intraocular pressure. The HA is first chemically modified, mixed with drug-loaded liposomes, and then crosslinked to obtain nanocomposite hydrogels. In vitro release study shows longer sustained release of latanoprost from composite hydrogels as compared to liposomes or hydrogels alone indicating additional resistance to drug diffusion because of the incorporation of liposomes inside the hydrogels. It is believed that these nanocomposite hydrogels, with controlled degradation properties and sustained release, could serve as potential drug delivery systems for many ocular diseases. ASTAR (Agency for Sci., Tech. and Research, S’pore) 2014-04-01T07:26:26Z 2019-12-06T21:00:39Z 2014-04-01T07:26:26Z 2019-12-06T21:00:39Z 2013 2013 Journal Article Widjaja, L. K., Bora, M., Chan, P. N. P. H., Lipik, V., Wong, T. T. L., & Venkatraman, S. S. (2013). Hyaluronic acid-based nanocomposite hydrogels for ocular drug delivery applications. Journal of Biomedical Materials Research Part A, 102(9), 3056–3065. 1549-3296 https://hdl.handle.net/10356/102812 http://hdl.handle.net/10220/19063 10.1002/jbm.a.34976 en Journal of biomedical materials research part A © 2013 Wiley Periodicals, Inc. |
| spellingShingle | DRNTU::Engineering::Materials::Biomaterials Widjaja, Leonardus Kresna Bora, Meghali Chan, Paul Ng Poh Huat Lipik, Vitali Wong, Tina T. L. Venkatraman, Subbu S. Hyaluronic acid-based nanocomposite hydrogels for ocular drug delivery applications |
| title | Hyaluronic acid-based nanocomposite hydrogels for ocular drug delivery applications |
| title_full | Hyaluronic acid-based nanocomposite hydrogels for ocular drug delivery applications |
| title_fullStr | Hyaluronic acid-based nanocomposite hydrogels for ocular drug delivery applications |
| title_full_unstemmed | Hyaluronic acid-based nanocomposite hydrogels for ocular drug delivery applications |
| title_short | Hyaluronic acid-based nanocomposite hydrogels for ocular drug delivery applications |
| title_sort | hyaluronic acid based nanocomposite hydrogels for ocular drug delivery applications |
| topic | DRNTU::Engineering::Materials::Biomaterials |
| url | https://hdl.handle.net/10356/102812 http://hdl.handle.net/10220/19063 |
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