Subcutaneous tissue response to titanium, poly(ϵ-caprolactone), and carbonate-substituted hydroxyapatite-coated poly(ϵ-caprolactone) plates : a rabbit study
The aim of this study was to evaluate the soft tissue response to poly(ϵ-caprolactone) (PCL) implants with and without carbonate-substituted hydroxyapatite (CHA) coating compared to the commonly used titanium alloy (Ti-6Al-4V)-machined surface. Experimental materials were implanted subcutaneously in...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2014
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| Online Access: | https://hdl.handle.net/10356/102919 http://hdl.handle.net/10220/19134 |
| _version_ | 1826119957263417344 |
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| author | Chanchareonsook, Nattharee Tideman, Henk Feinberg, Stephen E. Hollister, Scott J. Jongpaiboonkit, Leenaporn Kin, Liao Jansen, John A. |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Chanchareonsook, Nattharee Tideman, Henk Feinberg, Stephen E. Hollister, Scott J. Jongpaiboonkit, Leenaporn Kin, Liao Jansen, John A. |
| author_sort | Chanchareonsook, Nattharee |
| collection | NTU |
| description | The aim of this study was to evaluate the soft tissue response to poly(ϵ-caprolactone) (PCL) implants with and without carbonate-substituted hydroxyapatite (CHA) coating compared to the commonly used titanium alloy (Ti-6Al-4V)-machined surface. Experimental materials were implanted subcutaneously in New Zealand white rabbits for 5 weeks. The tissue attachment strength, as evaluated by a tissue peel test, histological and histomorphology analysis, as well as scanning electron microscopy were compared between groups. The peel test result revealed no statistically significant difference between groups. Histological analysis found fibrous capsule formation around all implant materials. The fibrous capsule around PCL implants with and without CHA coating was significantly thinner compared with the capsule thickness around the titanium implants. However, the inflammatory cells, as present at the fibrous capsule-implant interface, were found to be significantly lower in the Ti-group. In conclusion, the current data do not prove that PCL or PCL with a CHA coating results in a superior soft tissue response compared with a machined titanium implant. |
| first_indexed | 2024-10-01T05:08:38Z |
| format | Journal Article |
| id | ntu-10356/102919 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:08:38Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/1029192020-03-07T11:35:29Z Subcutaneous tissue response to titanium, poly(ϵ-caprolactone), and carbonate-substituted hydroxyapatite-coated poly(ϵ-caprolactone) plates : a rabbit study Chanchareonsook, Nattharee Tideman, Henk Feinberg, Stephen E. Hollister, Scott J. Jongpaiboonkit, Leenaporn Kin, Liao Jansen, John A. School of Chemical and Biomedical Engineering DRNTU::Engineering::Chemical engineering The aim of this study was to evaluate the soft tissue response to poly(ϵ-caprolactone) (PCL) implants with and without carbonate-substituted hydroxyapatite (CHA) coating compared to the commonly used titanium alloy (Ti-6Al-4V)-machined surface. Experimental materials were implanted subcutaneously in New Zealand white rabbits for 5 weeks. The tissue attachment strength, as evaluated by a tissue peel test, histological and histomorphology analysis, as well as scanning electron microscopy were compared between groups. The peel test result revealed no statistically significant difference between groups. Histological analysis found fibrous capsule formation around all implant materials. The fibrous capsule around PCL implants with and without CHA coating was significantly thinner compared with the capsule thickness around the titanium implants. However, the inflammatory cells, as present at the fibrous capsule-implant interface, were found to be significantly lower in the Ti-group. In conclusion, the current data do not prove that PCL or PCL with a CHA coating results in a superior soft tissue response compared with a machined titanium implant. 2014-04-07T02:06:44Z 2019-12-06T21:02:20Z 2014-04-07T02:06:44Z 2019-12-06T21:02:20Z 2013 2013 Journal Article Chanchareonsook, N., Tideman, H., Feinberg, S. E., Hollister, S. J., Jongpaiboonkit, L., Kin, L., et al. (2013). Subcutaneous tissue response to titanium, poly(ϵ-caprolactone), and carbonate-substituted hydroxyapatite-coated poly(ϵ-caprolactone) plates: A rabbit study. Journal of Biomedical Materials Research Part A, 101A(8), 2258-2266. 1549-3296 https://hdl.handle.net/10356/102919 http://hdl.handle.net/10220/19134 10.1002/jbm.a.34542 en Journal of biomedical materials research part A © 2013 Wiley Periodicals, Inc. |
| spellingShingle | DRNTU::Engineering::Chemical engineering Chanchareonsook, Nattharee Tideman, Henk Feinberg, Stephen E. Hollister, Scott J. Jongpaiboonkit, Leenaporn Kin, Liao Jansen, John A. Subcutaneous tissue response to titanium, poly(ϵ-caprolactone), and carbonate-substituted hydroxyapatite-coated poly(ϵ-caprolactone) plates : a rabbit study |
| title | Subcutaneous tissue response to titanium, poly(ϵ-caprolactone), and carbonate-substituted hydroxyapatite-coated poly(ϵ-caprolactone) plates : a rabbit study |
| title_full | Subcutaneous tissue response to titanium, poly(ϵ-caprolactone), and carbonate-substituted hydroxyapatite-coated poly(ϵ-caprolactone) plates : a rabbit study |
| title_fullStr | Subcutaneous tissue response to titanium, poly(ϵ-caprolactone), and carbonate-substituted hydroxyapatite-coated poly(ϵ-caprolactone) plates : a rabbit study |
| title_full_unstemmed | Subcutaneous tissue response to titanium, poly(ϵ-caprolactone), and carbonate-substituted hydroxyapatite-coated poly(ϵ-caprolactone) plates : a rabbit study |
| title_short | Subcutaneous tissue response to titanium, poly(ϵ-caprolactone), and carbonate-substituted hydroxyapatite-coated poly(ϵ-caprolactone) plates : a rabbit study |
| title_sort | subcutaneous tissue response to titanium poly ϵ caprolactone and carbonate substituted hydroxyapatite coated poly ϵ caprolactone plates a rabbit study |
| topic | DRNTU::Engineering::Chemical engineering |
| url | https://hdl.handle.net/10356/102919 http://hdl.handle.net/10220/19134 |
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