Natural products for the treatment of trachoma and chlamydia trachomatis
The neglected tropical disease (NTD) trachoma is currently the leading cause of eye disease in the world, and the pathogenic bacteria causing this condition, Chlamydia trachomatis, is also the most common sexually transmitted pathogenic bacterium. Although the serovars of this bacterial species typi...
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| Format: | Journal Article |
| Language: | English |
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2015
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| Online Access: | https://hdl.handle.net/10356/103294 http://hdl.handle.net/10220/25832 |
| _version_ | 1811692428720078848 |
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| author | Cho, Nam-Joon Potroz, Michael G. |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Cho, Nam-Joon Potroz, Michael G. |
| author_sort | Cho, Nam-Joon |
| collection | NTU |
| description | The neglected tropical disease (NTD) trachoma is currently the leading cause of eye disease in the world, and the pathogenic bacteria causing this condition, Chlamydia trachomatis, is also the most common sexually transmitted pathogenic bacterium. Although the serovars of this bacterial species typically vary between ocular and genital infections there is a clear connection between genital C. trachomatis infections and the development of trachoma in infants, such that the solutions to these infections are closely related. It is the unique life cycle of the C. trachomatis bacteria which primarily leads to chronic infections and challenges in treatment using conventional antibiotics. This life cycle involves stages of infective elementary bodies (EBs) and reproductive reticulate bodies (RBs). Most antibiotics only target the reproductive RBs and this often leads to the need for prolonged therapy which facilitates the development of drug resistant pathogens. It is through combining several compounds to obtain multiple antimicrobial mechanisms that we are most likely to develop a reliable means to address all these issues. Traditional and ethnobotanical medicine provides valuable resources for the development of novel formulations and treatment regimes based on synergistic and multi-compound therapy. In this review we intend to summarize the existing literature on the application of natural compounds for controlling trachoma and inhibiting chlamydial bacteria and explore the potential for the development of new treatment modalities. |
| first_indexed | 2024-10-01T06:35:38Z |
| format | Journal Article |
| id | ntu-10356/103294 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:35:38Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | ntu-10356/1032942023-07-14T15:55:35Z Natural products for the treatment of trachoma and chlamydia trachomatis Cho, Nam-Joon Potroz, Michael G. School of Materials Science & Engineering DRNTU::Science::Chemistry::Physical chemistry::Molecular structure and bonding The neglected tropical disease (NTD) trachoma is currently the leading cause of eye disease in the world, and the pathogenic bacteria causing this condition, Chlamydia trachomatis, is also the most common sexually transmitted pathogenic bacterium. Although the serovars of this bacterial species typically vary between ocular and genital infections there is a clear connection between genital C. trachomatis infections and the development of trachoma in infants, such that the solutions to these infections are closely related. It is the unique life cycle of the C. trachomatis bacteria which primarily leads to chronic infections and challenges in treatment using conventional antibiotics. This life cycle involves stages of infective elementary bodies (EBs) and reproductive reticulate bodies (RBs). Most antibiotics only target the reproductive RBs and this often leads to the need for prolonged therapy which facilitates the development of drug resistant pathogens. It is through combining several compounds to obtain multiple antimicrobial mechanisms that we are most likely to develop a reliable means to address all these issues. Traditional and ethnobotanical medicine provides valuable resources for the development of novel formulations and treatment regimes based on synergistic and multi-compound therapy. In this review we intend to summarize the existing literature on the application of natural compounds for controlling trachoma and inhibiting chlamydial bacteria and explore the potential for the development of new treatment modalities. NMRC (Natl Medical Research Council, S’pore) Published version 2015-06-08T06:42:39Z 2019-12-06T21:09:17Z 2015-06-08T06:42:39Z 2019-12-06T21:09:17Z 2015 2015 Journal Article Potroz, M. G., & Cho, N.-J. (2015). Natural products for the treatment of trachoma and chlamydia trachomatis. Molecules, 20(3), 4180-4203. 1420-3049 https://hdl.handle.net/10356/103294 http://hdl.handle.net/10220/25832 10.3390/molecules20034180 en Molecules © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). 24 p. application/pdf |
| spellingShingle | DRNTU::Science::Chemistry::Physical chemistry::Molecular structure and bonding Cho, Nam-Joon Potroz, Michael G. Natural products for the treatment of trachoma and chlamydia trachomatis |
| title | Natural products for the treatment of trachoma and chlamydia trachomatis |
| title_full | Natural products for the treatment of trachoma and chlamydia trachomatis |
| title_fullStr | Natural products for the treatment of trachoma and chlamydia trachomatis |
| title_full_unstemmed | Natural products for the treatment of trachoma and chlamydia trachomatis |
| title_short | Natural products for the treatment of trachoma and chlamydia trachomatis |
| title_sort | natural products for the treatment of trachoma and chlamydia trachomatis |
| topic | DRNTU::Science::Chemistry::Physical chemistry::Molecular structure and bonding |
| url | https://hdl.handle.net/10356/103294 http://hdl.handle.net/10220/25832 |
| work_keys_str_mv | AT chonamjoon naturalproductsforthetreatmentoftrachomaandchlamydiatrachomatis AT potrozmichaelg naturalproductsforthetreatmentoftrachomaandchlamydiatrachomatis |