Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors
The RIG-I-like receptors (RLRs)—RIG-I, MDA5, and LGP2—detect intracellular pathogenic RNA and elicit an antiviral immune response during viral infection. The protein architecture of the RLR family consists of multiple functional domains, including N-terminal Caspase Activation and Recruitment Domain...
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| Format: | Journal Article |
| Language: | English |
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2014
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| Online Access: | https://hdl.handle.net/10356/103313 http://hdl.handle.net/10220/19285 |
| _version_ | 1824454462923603968 |
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| author | Luo, Dahai |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Luo, Dahai |
| author_sort | Luo, Dahai |
| collection | NTU |
| description | The RIG-I-like receptors (RLRs)—RIG-I, MDA5, and LGP2—detect intracellular pathogenic RNA and elicit an antiviral immune response during viral infection. The protein architecture of the RLR family consists of multiple functional domains, including N-terminal Caspase Activation and Recruitment Domains (CARDs) for signaling initiation, a central RNA helicase core, and a C-terminal domain for RNA sensing. With these specialized sensing-and-responding modules, RLRs are able to selectively bind non-self RNA species and trigger downstream signaling events leading to interferon production. This article summarizes the recent progress toward defining the precise mechanisms of RNA recognition and subsequent signal induction by RLRs. |
| first_indexed | 2025-02-19T03:22:42Z |
| format | Journal Article |
| id | ntu-10356/103313 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:22:42Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/1033132022-02-16T16:28:03Z Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors Luo, Dahai Lee Kong Chian School of Medicine (LKCMedicine) DRNTU::Science::Medicine The RIG-I-like receptors (RLRs)—RIG-I, MDA5, and LGP2—detect intracellular pathogenic RNA and elicit an antiviral immune response during viral infection. The protein architecture of the RLR family consists of multiple functional domains, including N-terminal Caspase Activation and Recruitment Domains (CARDs) for signaling initiation, a central RNA helicase core, and a C-terminal domain for RNA sensing. With these specialized sensing-and-responding modules, RLRs are able to selectively bind non-self RNA species and trigger downstream signaling events leading to interferon production. This article summarizes the recent progress toward defining the precise mechanisms of RNA recognition and subsequent signal induction by RLRs. Accepted version 2014-04-30T08:42:01Z 2019-12-06T21:09:44Z 2014-04-30T08:42:01Z 2019-12-06T21:09:44Z 2014 2014 Journal Article Luo, D. (2014). Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors. RNA Biology, 11(1), 25-32. 1547-6286 https://hdl.handle.net/10356/103313 http://hdl.handle.net/10220/19285 10.4161/rna.27717 24457940 en RNA biology © 2014 Landes Bioscience. This is the author created version of a work that has been peer reviewed and accepted for publication by RNA Biology, Landes Bioscience. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.4161/rna.27717]. 8 p. application/pdf |
| spellingShingle | DRNTU::Science::Medicine Luo, Dahai Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors |
| title | Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors |
| title_full | Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors |
| title_fullStr | Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors |
| title_full_unstemmed | Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors |
| title_short | Toward a crystal-clear view of the viral RNA sensing and response by RIG-I-like receptors |
| title_sort | toward a crystal clear view of the viral rna sensing and response by rig i like receptors |
| topic | DRNTU::Science::Medicine |
| url | https://hdl.handle.net/10356/103313 http://hdl.handle.net/10220/19285 |
| work_keys_str_mv | AT luodahai towardacrystalclearviewoftheviralrnasensingandresponsebyrigilikereceptors |