Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms

Abdominal aortic aneurysms (AAAs) occur because of dilation of the infra-renal aorta to more than 150% of its initial diameter. Progression to rupture is aided by several pathophysiological and biomechanical factors. Surgical intervention is recommended when the aneurysm maximum transverse diameter...

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গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Canchi, Tejas, Saxena, Ashish, Narayanan, Sriram, Pwee, Esley Chin Hock, Ng, Eddie Yin Kwee
অন্যান্য লেখক: School of Mechanical and Aerospace Engineering
বিন্যাস: Journal Article
ভাষা:English
প্রকাশিত: 2019
বিষয়গুলি:
অনলাইন ব্যবহার করুন:https://hdl.handle.net/10356/103638
http://hdl.handle.net/10220/49494
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author Canchi, Tejas
Saxena, Ashish
Narayanan, Sriram
Pwee, Esley Chin Hock
Ng, Eddie Yin Kwee
author2 School of Mechanical and Aerospace Engineering
author_facet School of Mechanical and Aerospace Engineering
Canchi, Tejas
Saxena, Ashish
Narayanan, Sriram
Pwee, Esley Chin Hock
Ng, Eddie Yin Kwee
author_sort Canchi, Tejas
collection NTU
description Abdominal aortic aneurysms (AAAs) occur because of dilation of the infra-renal aorta to more than 150% of its initial diameter. Progression to rupture is aided by several pathophysiological and biomechanical factors. Surgical intervention is recommended when the aneurysm maximum transverse diameter (DAAA) exceeds 55 mm. A system model that incorporates biomechanical parameters will improve prognosis and establish a relationship between AAA geometry and rupture risk. Two Asian patient-specific AAA geometries were obtained from an IRB-approved vascular database. A biomechanical model based on the fluid–structure interaction (FSI) method was developed for a small aneurysm with DAAA of 35 mm and a large aneurysm with a corresponding diameter of 75 mm. The small aneurysm (patient 1) developed a maximum principal stress (PS1) of 3.16e5 Pa and the large aneurysm (patient 2) developed a PS1 of 2.32e5 Pa. Maximum deformation of arterial wall was 0.0020 m and 0.0022 m for patients 1 and 2 respectively. Location of maximum integral wall shear stress (WSS) (fluid) was different from that of PS1. Induced WSS was also higher in patient 1 (18.74 Pa vs 12.88 Pa). An FSI model incorporating the effect of both the structural and fluid domains aids in better understanding of the mechanics of AAA rupture. Patient 1, having a lower DAAA than patient 2, developed a larger PS1 and WSS. It may be concluded that DAAA may not be the sole determinant of AAA rupture risk.
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spelling ntu-10356/1036382023-03-04T17:20:34Z Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms Canchi, Tejas Saxena, Ashish Narayanan, Sriram Pwee, Esley Chin Hock Ng, Eddie Yin Kwee School of Mechanical and Aerospace Engineering Fluid–Structure Interaction Abdominal Aortic Aneurysm Abdominal aortic aneurysms (AAAs) occur because of dilation of the infra-renal aorta to more than 150% of its initial diameter. Progression to rupture is aided by several pathophysiological and biomechanical factors. Surgical intervention is recommended when the aneurysm maximum transverse diameter (DAAA) exceeds 55 mm. A system model that incorporates biomechanical parameters will improve prognosis and establish a relationship between AAA geometry and rupture risk. Two Asian patient-specific AAA geometries were obtained from an IRB-approved vascular database. A biomechanical model based on the fluid–structure interaction (FSI) method was developed for a small aneurysm with DAAA of 35 mm and a large aneurysm with a corresponding diameter of 75 mm. The small aneurysm (patient 1) developed a maximum principal stress (PS1) of 3.16e5 Pa and the large aneurysm (patient 2) developed a PS1 of 2.32e5 Pa. Maximum deformation of arterial wall was 0.0020 m and 0.0022 m for patients 1 and 2 respectively. Location of maximum integral wall shear stress (WSS) (fluid) was different from that of PS1. Induced WSS was also higher in patient 1 (18.74 Pa vs 12.88 Pa). An FSI model incorporating the effect of both the structural and fluid domains aids in better understanding of the mechanics of AAA rupture. Patient 1, having a lower DAAA than patient 2, developed a larger PS1 and WSS. It may be concluded that DAAA may not be the sole determinant of AAA rupture risk. Accepted version 2019-07-31T01:08:44Z 2019-12-06T21:16:51Z 2019-07-31T01:08:44Z 2019-12-06T21:16:51Z 2018 Journal Article Canchi, T., Saxena, A., Ng, E. Y. K., Pwee, E. C.H., & Narayanan, S. (2018). Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms. BioNanoScience, 8(4), 1035-1044. doi:10.1007/s12668-018-0554-z 2191-1630 https://hdl.handle.net/10356/103638 http://hdl.handle.net/10220/49494 10.1007/s12668-018-0554-z en BioNanoScience © 2018 Springer Science+Business Media, LLC, part of Springer Nature. 27 p. application/pdf
spellingShingle Fluid–Structure Interaction
Abdominal Aortic Aneurysm
Canchi, Tejas
Saxena, Ashish
Narayanan, Sriram
Pwee, Esley Chin Hock
Ng, Eddie Yin Kwee
Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms
title Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms
title_full Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms
title_fullStr Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms
title_full_unstemmed Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms
title_short Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms
title_sort application of fluid structure interaction methods to estimate the mechanics of rupture in asian abdominal aortic aneurysms
topic Fluid–Structure Interaction
Abdominal Aortic Aneurysm
url https://hdl.handle.net/10356/103638
http://hdl.handle.net/10220/49494
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