Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms
Abdominal aortic aneurysms (AAAs) occur because of dilation of the infra-renal aorta to more than 150% of its initial diameter. Progression to rupture is aided by several pathophysiological and biomechanical factors. Surgical intervention is recommended when the aneurysm maximum transverse diameter...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Language: | English |
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2019
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| Online Access: | https://hdl.handle.net/10356/103638 http://hdl.handle.net/10220/49494 |
| _version_ | 1826126415427272704 |
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| author | Canchi, Tejas Saxena, Ashish Narayanan, Sriram Pwee, Esley Chin Hock Ng, Eddie Yin Kwee |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Canchi, Tejas Saxena, Ashish Narayanan, Sriram Pwee, Esley Chin Hock Ng, Eddie Yin Kwee |
| author_sort | Canchi, Tejas |
| collection | NTU |
| description | Abdominal aortic aneurysms (AAAs) occur because of dilation of the infra-renal aorta to more than 150% of its initial diameter. Progression to rupture is aided by several pathophysiological and biomechanical factors. Surgical intervention is recommended when the aneurysm maximum transverse diameter (DAAA) exceeds 55 mm. A system model that incorporates biomechanical parameters will improve prognosis and establish a relationship between AAA geometry and rupture risk. Two Asian patient-specific AAA geometries were obtained from an IRB-approved vascular database. A biomechanical model based on the fluid–structure interaction (FSI) method was developed for a small aneurysm with DAAA of 35 mm and a large aneurysm with a corresponding diameter of 75 mm. The small aneurysm (patient 1) developed a maximum principal stress (PS1) of 3.16e5 Pa and the large aneurysm (patient 2) developed a PS1 of 2.32e5 Pa. Maximum deformation of arterial wall was 0.0020 m and 0.0022 m for patients 1 and 2 respectively. Location of maximum integral wall shear stress (WSS) (fluid) was different from that of PS1. Induced WSS was also higher in patient 1 (18.74 Pa vs 12.88 Pa). An FSI model incorporating the effect of both the structural and fluid domains aids in better understanding of the mechanics of AAA rupture. Patient 1, having a lower DAAA than patient 2, developed a larger PS1 and WSS. It may be concluded that DAAA may not be the sole determinant of AAA rupture risk. |
| first_indexed | 2024-10-01T06:52:17Z |
| format | Journal Article |
| id | ntu-10356/103638 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:52:17Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | ntu-10356/1036382023-03-04T17:20:34Z Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms Canchi, Tejas Saxena, Ashish Narayanan, Sriram Pwee, Esley Chin Hock Ng, Eddie Yin Kwee School of Mechanical and Aerospace Engineering Fluid–Structure Interaction Abdominal Aortic Aneurysm Abdominal aortic aneurysms (AAAs) occur because of dilation of the infra-renal aorta to more than 150% of its initial diameter. Progression to rupture is aided by several pathophysiological and biomechanical factors. Surgical intervention is recommended when the aneurysm maximum transverse diameter (DAAA) exceeds 55 mm. A system model that incorporates biomechanical parameters will improve prognosis and establish a relationship between AAA geometry and rupture risk. Two Asian patient-specific AAA geometries were obtained from an IRB-approved vascular database. A biomechanical model based on the fluid–structure interaction (FSI) method was developed for a small aneurysm with DAAA of 35 mm and a large aneurysm with a corresponding diameter of 75 mm. The small aneurysm (patient 1) developed a maximum principal stress (PS1) of 3.16e5 Pa and the large aneurysm (patient 2) developed a PS1 of 2.32e5 Pa. Maximum deformation of arterial wall was 0.0020 m and 0.0022 m for patients 1 and 2 respectively. Location of maximum integral wall shear stress (WSS) (fluid) was different from that of PS1. Induced WSS was also higher in patient 1 (18.74 Pa vs 12.88 Pa). An FSI model incorporating the effect of both the structural and fluid domains aids in better understanding of the mechanics of AAA rupture. Patient 1, having a lower DAAA than patient 2, developed a larger PS1 and WSS. It may be concluded that DAAA may not be the sole determinant of AAA rupture risk. Accepted version 2019-07-31T01:08:44Z 2019-12-06T21:16:51Z 2019-07-31T01:08:44Z 2019-12-06T21:16:51Z 2018 Journal Article Canchi, T., Saxena, A., Ng, E. Y. K., Pwee, E. C.H., & Narayanan, S. (2018). Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms. BioNanoScience, 8(4), 1035-1044. doi:10.1007/s12668-018-0554-z 2191-1630 https://hdl.handle.net/10356/103638 http://hdl.handle.net/10220/49494 10.1007/s12668-018-0554-z en BioNanoScience © 2018 Springer Science+Business Media, LLC, part of Springer Nature. 27 p. application/pdf |
| spellingShingle | Fluid–Structure Interaction Abdominal Aortic Aneurysm Canchi, Tejas Saxena, Ashish Narayanan, Sriram Pwee, Esley Chin Hock Ng, Eddie Yin Kwee Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms |
| title | Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms |
| title_full | Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms |
| title_fullStr | Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms |
| title_full_unstemmed | Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms |
| title_short | Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms |
| title_sort | application of fluid structure interaction methods to estimate the mechanics of rupture in asian abdominal aortic aneurysms |
| topic | Fluid–Structure Interaction Abdominal Aortic Aneurysm |
| url | https://hdl.handle.net/10356/103638 http://hdl.handle.net/10220/49494 |
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