Defects in β-cell Ca2+ dynamics in age-induced diabetes
Little is known about the molecular mechanisms underlying age-dependent deterioration in β-cell function. We now demonstrate that age-dependent impairment in insulin release, and thereby glucose homeostasis, is associated with subtle changes in Ca2+ dynamics in mouse β-cells. We show that these chan...
Main Authors: | Li, Luosheng, Trifunovic, Aleksandra, Köhler, Martin, Wang, Yixin, Petrovic Berglund, Jelena, Illies, Christopher, Juntti-Berggren, Lisa, Larsson, Nils-Göran, Berggren, Per-Olof |
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Other Authors: | Lee Kong Chian School of Medicine (LKCMedicine) |
Format: | Journal Article |
Language: | English |
Published: |
2015
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/103782 http://hdl.handle.net/10220/24587 |
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