Novel tungsten carbide nanorods : an intrinsic peroxidase mimetic with high activity and stability in aqueous and organic solvents
Tungsten carbide nanorods (WC NRs) are demonstrated for the first time to possess intrinsic peroxidase-like activity towards typical peroxidase substrates, such as 3, 3’, 5, 5’-tetramethylbenzidine (TMB) and o-phenylenediamine (OPD) in the presence of hydrogen peroxide (H2O2). The reactions catalyze...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2014
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| Online Access: | https://hdl.handle.net/10356/103783 http://hdl.handle.net/10220/19370 |
| _version_ | 1811690932006813696 |
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| author | Wang, Xin Li, Nan Yan, Ya Xia, Bao Yu Wang, Jing Yuan |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Wang, Xin Li, Nan Yan, Ya Xia, Bao Yu Wang, Jing Yuan |
| author_sort | Wang, Xin |
| collection | NTU |
| description | Tungsten carbide nanorods (WC NRs) are demonstrated for the first time to possess intrinsic peroxidase-like activity towards typical peroxidase substrates, such as 3, 3’, 5, 5’-tetramethylbenzidine (TMB) and o-phenylenediamine (OPD) in the presence of hydrogen peroxide (H2O2). The reactions catalyzed by these nanorods follow the Michaelis-Menten kinetics. The excellent catalytic performance of WC NRs could be attributed to their intrinsic catalytic acitity to efficiently accelerate the electron-transfer process and facilitate the decomposition of H2O2 to generate more numbers of reactive oxygen species (ROS).. Based upon the strong peroxidase-like activity of these WC NRs, a colorimetric sensor for H2O2 is designed, which provides good response towards H2O2 concentration over a range of 2×10-7 to 8×10-5 M with a detection limit of 60 nM. Moreover, the peroxidase-like activities of WC NRs with TMB as the substrate are investigated in both protic and aprotic organic media, showing different colorimetric reactions from that performed in aqueous solutions. In comparison with the natural horse radish peroxidase, WC NR exhibits excellent robustness of catalytic activity and considerable reusability, thus making it a promising mimic of peroxidase catalysts. |
| first_indexed | 2024-10-01T06:11:51Z |
| format | Journal Article |
| id | ntu-10356/103783 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:11:51Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/1037832023-12-29T06:50:25Z Novel tungsten carbide nanorods : an intrinsic peroxidase mimetic with high activity and stability in aqueous and organic solvents Wang, Xin Li, Nan Yan, Ya Xia, Bao Yu Wang, Jing Yuan School of Chemical and Biomedical Engineering Residues and Resource Reclamation Centre DRNTU::Science::Medicine::Biosensors Tungsten carbide nanorods (WC NRs) are demonstrated for the first time to possess intrinsic peroxidase-like activity towards typical peroxidase substrates, such as 3, 3’, 5, 5’-tetramethylbenzidine (TMB) and o-phenylenediamine (OPD) in the presence of hydrogen peroxide (H2O2). The reactions catalyzed by these nanorods follow the Michaelis-Menten kinetics. The excellent catalytic performance of WC NRs could be attributed to their intrinsic catalytic acitity to efficiently accelerate the electron-transfer process and facilitate the decomposition of H2O2 to generate more numbers of reactive oxygen species (ROS).. Based upon the strong peroxidase-like activity of these WC NRs, a colorimetric sensor for H2O2 is designed, which provides good response towards H2O2 concentration over a range of 2×10-7 to 8×10-5 M with a detection limit of 60 nM. Moreover, the peroxidase-like activities of WC NRs with TMB as the substrate are investigated in both protic and aprotic organic media, showing different colorimetric reactions from that performed in aqueous solutions. In comparison with the natural horse radish peroxidase, WC NR exhibits excellent robustness of catalytic activity and considerable reusability, thus making it a promising mimic of peroxidase catalysts. Accepted version 2014-05-19T04:49:14Z 2019-12-06T21:20:10Z 2014-05-19T04:49:14Z 2019-12-06T21:20:10Z 2013 2013 Journal Article Li, N., Yan, Y., Xia, B. Y., Wang, J. Y., & Wang, X. (2014). Novel tungsten carbide nanorods: An intrinsic peroxidase mimetic with high activity and stability in aqueous and organic solvents. Biosensors and Bioelectronics, 54, 521-527. 0956-5663 https://hdl.handle.net/10356/103783 http://hdl.handle.net/10220/19370 10.1016/j.bios.2013.11.040 en Biosensors and bioelectronics © 2013 Elsevier B.V. This is the author created version of a work that has been peer reviewed and accepted for publication by Biosensors and Bioelectronics, Elsevier B.V. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [DOI:http://dx.doi.org/10.1016/j.bios.2013.11.040]. 7 p. application/pdf |
| spellingShingle | DRNTU::Science::Medicine::Biosensors Wang, Xin Li, Nan Yan, Ya Xia, Bao Yu Wang, Jing Yuan Novel tungsten carbide nanorods : an intrinsic peroxidase mimetic with high activity and stability in aqueous and organic solvents |
| title | Novel tungsten carbide nanorods : an intrinsic peroxidase mimetic with high activity and stability in aqueous and organic solvents |
| title_full | Novel tungsten carbide nanorods : an intrinsic peroxidase mimetic with high activity and stability in aqueous and organic solvents |
| title_fullStr | Novel tungsten carbide nanorods : an intrinsic peroxidase mimetic with high activity and stability in aqueous and organic solvents |
| title_full_unstemmed | Novel tungsten carbide nanorods : an intrinsic peroxidase mimetic with high activity and stability in aqueous and organic solvents |
| title_short | Novel tungsten carbide nanorods : an intrinsic peroxidase mimetic with high activity and stability in aqueous and organic solvents |
| title_sort | novel tungsten carbide nanorods an intrinsic peroxidase mimetic with high activity and stability in aqueous and organic solvents |
| topic | DRNTU::Science::Medicine::Biosensors |
| url | https://hdl.handle.net/10356/103783 http://hdl.handle.net/10220/19370 |
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