Next-generation transgenic mice for optogenetic analysis of neural circuits
Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit p...
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| Format: | Journal Article |
| Language: | English |
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2014
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| Online Access: | https://hdl.handle.net/10356/103882 http://hdl.handle.net/10220/19337 |
| _version_ | 1824453644378963968 |
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| author | Feng, Guoping Asrican, Brent Augustine, George J. Berglund, Ken Chen, Susu Chow, Nick Gloss, Bernd Deisseroth, Karl Mancuso, James Hira, Riichiro Hoffmann, Carolin Tan, Gregory Kasai, Haruo Katarya, Malvika Kim, Jinsook Kudolo, John Lee, Li Ming Lo, Shun Qiang Matsuzaki, Masanori Nakajima, Ryuichi Qiu, Li Tang, Yanxia Ting, Jonathan T. Tsuda, Sachiko Wen, Lei Zhang, Xuying Zhao, Shengli |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Feng, Guoping Asrican, Brent Augustine, George J. Berglund, Ken Chen, Susu Chow, Nick Gloss, Bernd Deisseroth, Karl Mancuso, James Hira, Riichiro Hoffmann, Carolin Tan, Gregory Kasai, Haruo Katarya, Malvika Kim, Jinsook Kudolo, John Lee, Li Ming Lo, Shun Qiang Matsuzaki, Masanori Nakajima, Ryuichi Qiu, Li Tang, Yanxia Ting, Jonathan T. Tsuda, Sachiko Wen, Lei Zhang, Xuying Zhao, Shengli |
| author_sort | Feng, Guoping |
| collection | NTU |
| description | Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit photoinhibition or photostimulation both in vitro and in vivo. Our results also reveal the important influence of fluorescent tags on optogenetic probe expression and function in transgenic mice. |
| first_indexed | 2025-02-19T03:09:42Z |
| format | Journal Article |
| id | ntu-10356/103882 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:09:42Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/1038822022-02-16T16:28:23Z Next-generation transgenic mice for optogenetic analysis of neural circuits Feng, Guoping Asrican, Brent Augustine, George J. Berglund, Ken Chen, Susu Chow, Nick Gloss, Bernd Deisseroth, Karl Mancuso, James Hira, Riichiro Hoffmann, Carolin Tan, Gregory Kasai, Haruo Katarya, Malvika Kim, Jinsook Kudolo, John Lee, Li Ming Lo, Shun Qiang Matsuzaki, Masanori Nakajima, Ryuichi Qiu, Li Tang, Yanxia Ting, Jonathan T. Tsuda, Sachiko Wen, Lei Zhang, Xuying Zhao, Shengli Lee Kong Chian School of Medicine (LKCMedicine) DRNTU::Science::Medicine Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit photoinhibition or photostimulation both in vitro and in vivo. Our results also reveal the important influence of fluorescent tags on optogenetic probe expression and function in transgenic mice. Published version 2014-05-15T03:27:44Z 2019-12-06T21:22:13Z 2014-05-15T03:27:44Z 2019-12-06T21:22:13Z 2013 2013 Journal Article Asrican, B., Augustine, G. J., Berglund, K., Chen, S., Chow, N., Deisseroth, K., et al. (2013). Next-generation transgenic mice for optogenetic analysis of neural circuits. Frontiers in Neural Circuits, 7, 160-. 1662-5110 https://hdl.handle.net/10356/103882 http://hdl.handle.net/10220/19337 10.3389/fncir.2013.00160 24324405 en Frontiers in neural circuits © The Author(s). This paper was published in Frontiers in Neural Circuits and is made available as an electronic reprint (preprint) with permission of Frontiers. The paper can be found at the following official DOI: http://dx.doi.org/10.3389/fncir.2013.00160. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 24 p. application/pdf |
| spellingShingle | DRNTU::Science::Medicine Feng, Guoping Asrican, Brent Augustine, George J. Berglund, Ken Chen, Susu Chow, Nick Gloss, Bernd Deisseroth, Karl Mancuso, James Hira, Riichiro Hoffmann, Carolin Tan, Gregory Kasai, Haruo Katarya, Malvika Kim, Jinsook Kudolo, John Lee, Li Ming Lo, Shun Qiang Matsuzaki, Masanori Nakajima, Ryuichi Qiu, Li Tang, Yanxia Ting, Jonathan T. Tsuda, Sachiko Wen, Lei Zhang, Xuying Zhao, Shengli Next-generation transgenic mice for optogenetic analysis of neural circuits |
| title | Next-generation transgenic mice for optogenetic analysis of neural circuits |
| title_full | Next-generation transgenic mice for optogenetic analysis of neural circuits |
| title_fullStr | Next-generation transgenic mice for optogenetic analysis of neural circuits |
| title_full_unstemmed | Next-generation transgenic mice for optogenetic analysis of neural circuits |
| title_short | Next-generation transgenic mice for optogenetic analysis of neural circuits |
| title_sort | next generation transgenic mice for optogenetic analysis of neural circuits |
| topic | DRNTU::Science::Medicine |
| url | https://hdl.handle.net/10356/103882 http://hdl.handle.net/10220/19337 |
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