Manganese doped fluorescent paramagnetic nanocrystals for dual-modal imaging
In this work, dual-modal (fluorescence and magnetic resonance) imaging capabilities of water-soluble, low-toxicity, monodisperse Mn-doped ZnSe nanocrystals (NCs) with a size (6.5 nm) below the optimum kidney cutoff limit (10 nm) are reported. Synthesizing Mn-doped ZnSe NCs with varying Mn2+ concentr...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2015
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| Online Access: | https://hdl.handle.net/10356/103959 http://hdl.handle.net/10220/24659 |
| _version_ | 1824456838384451584 |
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| author | Sharma, Vijay Kumar Gokyar, Sayim Kelestemur, Yusuf Erdem, Talha Unal, Emre Demir, Hilmi Volkan |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Sharma, Vijay Kumar Gokyar, Sayim Kelestemur, Yusuf Erdem, Talha Unal, Emre Demir, Hilmi Volkan |
| author_sort | Sharma, Vijay Kumar |
| collection | NTU |
| description | In this work, dual-modal (fluorescence and magnetic resonance) imaging capabilities of water-soluble, low-toxicity, monodisperse Mn-doped ZnSe nanocrystals (NCs) with a size (6.5 nm) below the optimum kidney cutoff limit (10 nm) are reported. Synthesizing Mn-doped ZnSe NCs with varying Mn2+ concentrations, a systematic investigation of the optical properties of these NCs by using photoluminescence (PL) and time resolved fluorescence are demonstrated. The elemental properties of these NCs using X-ray photoelectron spectroscopy and inductive coupled plasma-mass spectroscopy confirming Mn2+ doping is confined to the core of these NCs are also presented. It is observed that with increasing Mn2+ concentration the PL intensity first increases, reaching a maximum at Mn2+ concentration of 3.2 at% (achieving a PL quantum yield (QY) of 37%), after which it starts to decrease. Here, this high-efficiency sample is demonstrated for applications in dual-modal imaging. These NCs are further made water-soluble by ligand exchange using 3-mercaptopropionic acid, preserving their PL QY as high as 18%. At the same time, these NCs exhibit high relaxivity (≈2.95 mM−1 s−1) to obtain MR contrast at 25 °C, 3 T. Therefore, the Mn2+ doping in these water-soluble Cd-free NCs are sufficient to produce contrast for both fluorescence and magnetic resonance imaging techniques. |
| first_indexed | 2025-02-19T04:00:28Z |
| format | Journal Article |
| id | ntu-10356/103959 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T04:00:28Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | ntu-10356/1039592020-03-07T14:00:35Z Manganese doped fluorescent paramagnetic nanocrystals for dual-modal imaging Sharma, Vijay Kumar Gokyar, Sayim Kelestemur, Yusuf Erdem, Talha Unal, Emre Demir, Hilmi Volkan School of Electrical and Electronic Engineering DRNTU::Engineering::Computer science and engineering::Computing methodologies::Image processing and computer vision In this work, dual-modal (fluorescence and magnetic resonance) imaging capabilities of water-soluble, low-toxicity, monodisperse Mn-doped ZnSe nanocrystals (NCs) with a size (6.5 nm) below the optimum kidney cutoff limit (10 nm) are reported. Synthesizing Mn-doped ZnSe NCs with varying Mn2+ concentrations, a systematic investigation of the optical properties of these NCs by using photoluminescence (PL) and time resolved fluorescence are demonstrated. The elemental properties of these NCs using X-ray photoelectron spectroscopy and inductive coupled plasma-mass spectroscopy confirming Mn2+ doping is confined to the core of these NCs are also presented. It is observed that with increasing Mn2+ concentration the PL intensity first increases, reaching a maximum at Mn2+ concentration of 3.2 at% (achieving a PL quantum yield (QY) of 37%), after which it starts to decrease. Here, this high-efficiency sample is demonstrated for applications in dual-modal imaging. These NCs are further made water-soluble by ligand exchange using 3-mercaptopropionic acid, preserving their PL QY as high as 18%. At the same time, these NCs exhibit high relaxivity (≈2.95 mM−1 s−1) to obtain MR contrast at 25 °C, 3 T. Therefore, the Mn2+ doping in these water-soluble Cd-free NCs are sufficient to produce contrast for both fluorescence and magnetic resonance imaging techniques. 2015-01-16T07:47:16Z 2019-12-06T21:23:35Z 2015-01-16T07:47:16Z 2019-12-06T21:23:35Z 2014 2014 Journal Article Sharma, V. K., Gokyar, S., Kelestemur, Y., Erdem, T., Unal, E., & Demir, H. V. (2014). Manganese doped fluorescent paramagnetic nanocrystals for dual-modal imaging. Small, 10(23), 4961-4966. 1613-6810 https://hdl.handle.net/10356/103959 http://hdl.handle.net/10220/24659 10.1002/smll.201401143 en Small © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| spellingShingle | DRNTU::Engineering::Computer science and engineering::Computing methodologies::Image processing and computer vision Sharma, Vijay Kumar Gokyar, Sayim Kelestemur, Yusuf Erdem, Talha Unal, Emre Demir, Hilmi Volkan Manganese doped fluorescent paramagnetic nanocrystals for dual-modal imaging |
| title | Manganese doped fluorescent paramagnetic nanocrystals for dual-modal imaging |
| title_full | Manganese doped fluorescent paramagnetic nanocrystals for dual-modal imaging |
| title_fullStr | Manganese doped fluorescent paramagnetic nanocrystals for dual-modal imaging |
| title_full_unstemmed | Manganese doped fluorescent paramagnetic nanocrystals for dual-modal imaging |
| title_short | Manganese doped fluorescent paramagnetic nanocrystals for dual-modal imaging |
| title_sort | manganese doped fluorescent paramagnetic nanocrystals for dual modal imaging |
| topic | DRNTU::Engineering::Computer science and engineering::Computing methodologies::Image processing and computer vision |
| url | https://hdl.handle.net/10356/103959 http://hdl.handle.net/10220/24659 |
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