Bimodal collagen fibril diameter distributions direct age-related variations in tendon resilience and resistance to rupture
Scaling relationships have been formulated to investigate the influence of collagen fibril diameter (D) on age-related variations in the strain energy density of tendon. Transmission electron microscopy was used to quantify D in tail tendon from 1.7- to 35.3-mo-old (C57BL/6) male mice. Frequency his...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/103968 http://hdl.handle.net/10220/17193 |
| _version_ | 1811683227436318720 |
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| author | Holmes, D. F. Lu, Y. Purslow, P. P. Goh, K. L. Kadler, K. E. Wess, T. J. Béchet, Daniel |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Holmes, D. F. Lu, Y. Purslow, P. P. Goh, K. L. Kadler, K. E. Wess, T. J. Béchet, Daniel |
| author_sort | Holmes, D. F. |
| collection | NTU |
| description | Scaling relationships have been formulated to investigate the influence of collagen fibril diameter (D) on age-related variations in the strain energy density of tendon. Transmission electron microscopy was used to quantify D in tail tendon from 1.7- to 35.3-mo-old (C57BL/6) male mice. Frequency histograms of D for all age groups were modeled as two normally distributed subpopulations with smaller (DD1) and larger (DD2) mean Ds, respectively. Both DD1 and DD2 increase from 1.6 to 4.0 mo but decrease thereafter. From tensile tests to rupture, two strain energy densities were calculated: 1) uE [from initial loading until the yield stress (σY)], which contributes primarily to tendon resilience, and 2) uF [from σY through the maximum stress (σU) until rupture], which relates primarily to resistance of the tendons to rupture. As measured by the normalized strain energy densities uE/σY and uF/σU, both the resilience and resistance to rupture increase with increasing age and peak at 23.0 and 4.0 mo, respectively, before decreasing thereafter. Multiple regression analysis reveals that increases in uE/σY (resilience energy) are associated with decreases in DD1 and increases in DD2, whereas uF/σU (rupture energy) is associated with increases in DD1 alone. These findings support a model where age-related variations in tendon resilience and resistance to rupture can be directed by subtle changes in the bimodal distribution of Ds. |
| first_indexed | 2024-10-01T04:09:23Z |
| format | Journal Article |
| id | ntu-10356/103968 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:09:23Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/1039682022-02-16T16:29:27Z Bimodal collagen fibril diameter distributions direct age-related variations in tendon resilience and resistance to rupture Holmes, D. F. Lu, Y. Purslow, P. P. Goh, K. L. Kadler, K. E. Wess, T. J. Béchet, Daniel School of Chemical and Biomedical Engineering DRNTU::Science::Biological sciences::Human anatomy and physiology Scaling relationships have been formulated to investigate the influence of collagen fibril diameter (D) on age-related variations in the strain energy density of tendon. Transmission electron microscopy was used to quantify D in tail tendon from 1.7- to 35.3-mo-old (C57BL/6) male mice. Frequency histograms of D for all age groups were modeled as two normally distributed subpopulations with smaller (DD1) and larger (DD2) mean Ds, respectively. Both DD1 and DD2 increase from 1.6 to 4.0 mo but decrease thereafter. From tensile tests to rupture, two strain energy densities were calculated: 1) uE [from initial loading until the yield stress (σY)], which contributes primarily to tendon resilience, and 2) uF [from σY through the maximum stress (σU) until rupture], which relates primarily to resistance of the tendons to rupture. As measured by the normalized strain energy densities uE/σY and uF/σU, both the resilience and resistance to rupture increase with increasing age and peak at 23.0 and 4.0 mo, respectively, before decreasing thereafter. Multiple regression analysis reveals that increases in uE/σY (resilience energy) are associated with decreases in DD1 and increases in DD2, whereas uF/σU (rupture energy) is associated with increases in DD1 alone. These findings support a model where age-related variations in tendon resilience and resistance to rupture can be directed by subtle changes in the bimodal distribution of Ds. 2013-11-01T01:27:32Z 2019-12-06T21:23:41Z 2013-11-01T01:27:32Z 2019-12-06T21:23:41Z 2012 2012 Journal Article Goh, K. L., Holmes, D. F., Lu, Y., Purslow, P. P., Kadler, K. E., Bechet, D., et al. (2012). Bimodal collagen fibril diameter distributions direct age-related variations in tendon resilience and resistance to rupture. Journal of applied physiology, 113(6), 878-888. https://hdl.handle.net/10356/103968 http://hdl.handle.net/10220/17193 10.1152/japplphysiol.00258.2012 22837169 en Journal of applied physiology |
| spellingShingle | DRNTU::Science::Biological sciences::Human anatomy and physiology Holmes, D. F. Lu, Y. Purslow, P. P. Goh, K. L. Kadler, K. E. Wess, T. J. Béchet, Daniel Bimodal collagen fibril diameter distributions direct age-related variations in tendon resilience and resistance to rupture |
| title | Bimodal collagen fibril diameter distributions direct age-related variations in tendon resilience and resistance to rupture |
| title_full | Bimodal collagen fibril diameter distributions direct age-related variations in tendon resilience and resistance to rupture |
| title_fullStr | Bimodal collagen fibril diameter distributions direct age-related variations in tendon resilience and resistance to rupture |
| title_full_unstemmed | Bimodal collagen fibril diameter distributions direct age-related variations in tendon resilience and resistance to rupture |
| title_short | Bimodal collagen fibril diameter distributions direct age-related variations in tendon resilience and resistance to rupture |
| title_sort | bimodal collagen fibril diameter distributions direct age related variations in tendon resilience and resistance to rupture |
| topic | DRNTU::Science::Biological sciences::Human anatomy and physiology |
| url | https://hdl.handle.net/10356/103968 http://hdl.handle.net/10220/17193 |
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