Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells
Many mitotic kinases have been targeted for the development of anti-cancer drugs, and inhibitors of these kinases have been expected to perform well for cancer therapy. Efforts focused on selecting good targets and finding specific drugs to target are especially needed, largely due to the increased...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2015
|
| Online Access: | https://hdl.handle.net/10356/103986 http://hdl.handle.net/10220/38799 |
| _version_ | 1826110792646262784 |
|---|---|
| author | Kim, Seong-Hoon Ryu, Hye Guk Lee, Juhyun Shin, Joon Harikishore, Amaravadhi Jung, Hoe-Youn Kim, Ye Seul Lyu, Ha-Na Oh, Eunji Baek, Nam-In Choi, Kwan-Yong Yoon, Ho Sup Kim, Kyong-Tai |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Kim, Seong-Hoon Ryu, Hye Guk Lee, Juhyun Shin, Joon Harikishore, Amaravadhi Jung, Hoe-Youn Kim, Ye Seul Lyu, Ha-Na Oh, Eunji Baek, Nam-In Choi, Kwan-Yong Yoon, Ho Sup Kim, Kyong-Tai |
| author_sort | Kim, Seong-Hoon |
| collection | NTU |
| description | Many mitotic kinases have been targeted for the development of anti-cancer drugs, and inhibitors of these kinases have been expected to perform well for cancer therapy. Efforts focused on selecting good targets and finding specific drugs to target are especially needed, largely due to the increased frequency of anti-cancer drugs used in the treatment of lung cancer. Vaccinia-related kinase 1 (VRK1) is a master regulator in lung adenocarcinoma and is considered a key molecule in the adaptive pathway, which mainly controls cell survival. We found that ursolic acid (UA) inhibits the catalytic activity of VRK1 via direct binding to the catalytic domain of VRK1. UA weakens surveillance mechanisms by blocking 53BP1 foci formation induced by VRK1 in lung cancer cells, and possesses synergistic anti-cancer effects with DNA damaging drugs. Taken together, UA can be a good anti-cancer agent for targeted therapy or combination therapy with DNA damaging drugs for lung cancer patients. |
| first_indexed | 2024-10-01T02:40:17Z |
| format | Journal Article |
| id | ntu-10356/103986 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:40:17Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | ntu-10356/1039862023-02-28T17:05:28Z Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells Kim, Seong-Hoon Ryu, Hye Guk Lee, Juhyun Shin, Joon Harikishore, Amaravadhi Jung, Hoe-Youn Kim, Ye Seul Lyu, Ha-Na Oh, Eunji Baek, Nam-In Choi, Kwan-Yong Yoon, Ho Sup Kim, Kyong-Tai School of Biological Sciences Many mitotic kinases have been targeted for the development of anti-cancer drugs, and inhibitors of these kinases have been expected to perform well for cancer therapy. Efforts focused on selecting good targets and finding specific drugs to target are especially needed, largely due to the increased frequency of anti-cancer drugs used in the treatment of lung cancer. Vaccinia-related kinase 1 (VRK1) is a master regulator in lung adenocarcinoma and is considered a key molecule in the adaptive pathway, which mainly controls cell survival. We found that ursolic acid (UA) inhibits the catalytic activity of VRK1 via direct binding to the catalytic domain of VRK1. UA weakens surveillance mechanisms by blocking 53BP1 foci formation induced by VRK1 in lung cancer cells, and possesses synergistic anti-cancer effects with DNA damaging drugs. Taken together, UA can be a good anti-cancer agent for targeted therapy or combination therapy with DNA damaging drugs for lung cancer patients. Published version 2015-10-13T08:37:22Z 2019-12-06T21:23:58Z 2015-10-13T08:37:22Z 2019-12-06T21:23:58Z 2015 2015 Journal Article Kim, S.-H., Ryu, H. G., Lee, J., Shin, J., Harikishore, A., Jung, H.-Y., et al. (2015). Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells. Scientific Reports, 5, 14570-. 2045-2322 https://hdl.handle.net/10356/103986 http://hdl.handle.net/10220/38799 10.1038/srep14570 26412148 en Scientific Reports This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ application/pdf |
| spellingShingle | Kim, Seong-Hoon Ryu, Hye Guk Lee, Juhyun Shin, Joon Harikishore, Amaravadhi Jung, Hoe-Youn Kim, Ye Seul Lyu, Ha-Na Oh, Eunji Baek, Nam-In Choi, Kwan-Yong Yoon, Ho Sup Kim, Kyong-Tai Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells |
| title | Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells |
| title_full | Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells |
| title_fullStr | Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells |
| title_full_unstemmed | Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells |
| title_short | Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells |
| title_sort | ursolic acid exerts anti cancer activity by suppressing vaccinia related kinase 1 mediated damage repair in lung cancer cells |
| url | https://hdl.handle.net/10356/103986 http://hdl.handle.net/10220/38799 |
| work_keys_str_mv | AT kimseonghoon ursolicacidexertsanticanceractivitybysuppressingvacciniarelatedkinase1mediateddamagerepairinlungcancercells AT ryuhyeguk ursolicacidexertsanticanceractivitybysuppressingvacciniarelatedkinase1mediateddamagerepairinlungcancercells AT leejuhyun ursolicacidexertsanticanceractivitybysuppressingvacciniarelatedkinase1mediateddamagerepairinlungcancercells AT shinjoon ursolicacidexertsanticanceractivitybysuppressingvacciniarelatedkinase1mediateddamagerepairinlungcancercells AT harikishoreamaravadhi ursolicacidexertsanticanceractivitybysuppressingvacciniarelatedkinase1mediateddamagerepairinlungcancercells AT junghoeyoun ursolicacidexertsanticanceractivitybysuppressingvacciniarelatedkinase1mediateddamagerepairinlungcancercells AT kimyeseul ursolicacidexertsanticanceractivitybysuppressingvacciniarelatedkinase1mediateddamagerepairinlungcancercells AT lyuhana ursolicacidexertsanticanceractivitybysuppressingvacciniarelatedkinase1mediateddamagerepairinlungcancercells AT oheunji ursolicacidexertsanticanceractivitybysuppressingvacciniarelatedkinase1mediateddamagerepairinlungcancercells AT baeknamin ursolicacidexertsanticanceractivitybysuppressingvacciniarelatedkinase1mediateddamagerepairinlungcancercells AT choikwanyong ursolicacidexertsanticanceractivitybysuppressingvacciniarelatedkinase1mediateddamagerepairinlungcancercells AT yoonhosup ursolicacidexertsanticanceractivitybysuppressingvacciniarelatedkinase1mediateddamagerepairinlungcancercells AT kimkyongtai ursolicacidexertsanticanceractivitybysuppressingvacciniarelatedkinase1mediateddamagerepairinlungcancercells |