R-Loops in proliferating cells but not in the brain : implications for AOA2 and other autosomal recessive ataxias

R-Loops in proliferating cells but not in the brain : implications for AOA2 and other autosomal recessive ataxias

Disruption of the Setx gene, defective in ataxia oculomotor apraxia type 2 (AOA2) leads to the accumulation of DNA/RNA hybrids (R-loops), failure of meiotic recombination and infertility in mice. We report here the presence of R-loops in the testes from other autosomal recessive ataxia mouse models,...

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Bibliographic Details
Main Authors: Yeo, Abrey J., Becherel, Olivier J., Luff, John E., Cullen, Jason K., Wongsurawat, Thidathip, Jenjaroenpoon, Piroon, Kuznetsov, Vladimir A., McKinnon, Peter J., Lavin, Martin F.
Other Authors: Gueven, Nuri
Format: Journal Article
Language:English
Published: 2014
Subjects:
DRNTU::Engineering::Computer science and engineering
Online Access:https://hdl.handle.net/10356/104114
http://hdl.handle.net/10220/19519

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