Photocontrolled nuclear-targeted drug delivery by single component photoresponsive fluorescent organic nanoparticles of acridin-9-methanol
We report for the first time an organic nanoparticle based nuclear-targeted photoresponsive drug delivery system (DDS) for regulated anticancer drug release. Acridin-9-methanol fluorescent organic nanoparticles used in this DDS performed three important roles: (i) ″nuclear-targeted nanocarrier″ for...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/104152 http://hdl.handle.net/10220/19434 |
| _version_ | 1826112543220826112 |
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| author | Banerjee, Deb Ranjan Ghosh, Sudip Kumar Nguyen, Kim Truc Ma, Xing Qu, Qiuyu Zhao, Yanli Pradeep Singh, N. D. Jana, Avijit Saha, Biswajit |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Banerjee, Deb Ranjan Ghosh, Sudip Kumar Nguyen, Kim Truc Ma, Xing Qu, Qiuyu Zhao, Yanli Pradeep Singh, N. D. Jana, Avijit Saha, Biswajit |
| author_sort | Banerjee, Deb Ranjan |
| collection | NTU |
| description | We report for the first time an organic nanoparticle based nuclear-targeted photoresponsive drug delivery system (DDS) for regulated anticancer drug release. Acridin-9-methanol fluorescent organic nanoparticles used in this DDS performed three important roles: (i) ″nuclear-targeted nanocarrier″ for drug delivery, (ii) ″phototrigger″ for regulated drug release, and (iii) fluorescent chromophore for cell imaging. In vitro biological studies reveal acridin-9-methanol nanoparticles of 60 nm size to be very efficient in delivering the anticancer drug chlorambucil into the target nucleus, killing the cancer cells upon irradiation. Such targeted organic nanoparticles with good biocompatibility, cellular uptake property, and efficient photoregulated drug release ability will be of great benefit in the field of targeted intracellular controlled drug release. |
| first_indexed | 2024-10-01T03:08:46Z |
| format | Journal Article |
| id | ntu-10356/104152 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:08:46Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/1041522020-06-01T10:21:16Z Photocontrolled nuclear-targeted drug delivery by single component photoresponsive fluorescent organic nanoparticles of acridin-9-methanol Banerjee, Deb Ranjan Ghosh, Sudip Kumar Nguyen, Kim Truc Ma, Xing Qu, Qiuyu Zhao, Yanli Pradeep Singh, N. D. Jana, Avijit Saha, Biswajit School of Materials Science & Engineering School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Organic chemistry We report for the first time an organic nanoparticle based nuclear-targeted photoresponsive drug delivery system (DDS) for regulated anticancer drug release. Acridin-9-methanol fluorescent organic nanoparticles used in this DDS performed three important roles: (i) ″nuclear-targeted nanocarrier″ for drug delivery, (ii) ″phototrigger″ for regulated drug release, and (iii) fluorescent chromophore for cell imaging. In vitro biological studies reveal acridin-9-methanol nanoparticles of 60 nm size to be very efficient in delivering the anticancer drug chlorambucil into the target nucleus, killing the cancer cells upon irradiation. Such targeted organic nanoparticles with good biocompatibility, cellular uptake property, and efficient photoregulated drug release ability will be of great benefit in the field of targeted intracellular controlled drug release. 2014-05-22T09:02:42Z 2019-12-06T21:27:34Z 2014-05-22T09:02:42Z 2019-12-06T21:27:34Z 2013 2013 Journal Article Jana, A., Saha, B., Banerjee, D. R., Ghosh, S. K., Nguyen, K. T., Ma, X., et al. (2013). Photocontrolled Nuclear-Targeted Drug Delivery by Single Component Photoresponsive Fluorescent Organic Nanoparticles of Acridin-9-Methanol. Bioconjugate Chemistry, 24(11), 1828–1839. 1043-1802 https://hdl.handle.net/10356/104152 http://hdl.handle.net/10220/19434 10.1021/bc400170r 179627 en Bioconjugate chemistry © 2013 American Chemical Society. |
| spellingShingle | DRNTU::Science::Chemistry::Organic chemistry Banerjee, Deb Ranjan Ghosh, Sudip Kumar Nguyen, Kim Truc Ma, Xing Qu, Qiuyu Zhao, Yanli Pradeep Singh, N. D. Jana, Avijit Saha, Biswajit Photocontrolled nuclear-targeted drug delivery by single component photoresponsive fluorescent organic nanoparticles of acridin-9-methanol |
| title | Photocontrolled nuclear-targeted drug delivery by single component photoresponsive fluorescent organic nanoparticles of acridin-9-methanol |
| title_full | Photocontrolled nuclear-targeted drug delivery by single component photoresponsive fluorescent organic nanoparticles of acridin-9-methanol |
| title_fullStr | Photocontrolled nuclear-targeted drug delivery by single component photoresponsive fluorescent organic nanoparticles of acridin-9-methanol |
| title_full_unstemmed | Photocontrolled nuclear-targeted drug delivery by single component photoresponsive fluorescent organic nanoparticles of acridin-9-methanol |
| title_short | Photocontrolled nuclear-targeted drug delivery by single component photoresponsive fluorescent organic nanoparticles of acridin-9-methanol |
| title_sort | photocontrolled nuclear targeted drug delivery by single component photoresponsive fluorescent organic nanoparticles of acridin 9 methanol |
| topic | DRNTU::Science::Chemistry::Organic chemistry |
| url | https://hdl.handle.net/10356/104152 http://hdl.handle.net/10220/19434 |
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