Perylene-3-ylmethanol : fluorescent organic nanoparticles as a single-component photoresponsive nanocarrier with real-time monitoring of anticancer drug release
We report for the first time the use of perylene-3-ylmethanol fluorescent organic nanoparticles as a drug delivery system. In the present system, perylene-3-ylmethanol nanoparticles performed four important roles: (i) “nanocarriers” for drug delivery; (ii) “phototriggers” for the drug release; (iii)...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2014
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| Online Access: | https://hdl.handle.net/10356/104213 http://hdl.handle.net/10220/19430 |
| _version_ | 1826127657314549760 |
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| author | Jana, Avijit Devi, K. Sanjana P. Maiti, Tapas K. Singh, N. D. Pradeep |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Jana, Avijit Devi, K. Sanjana P. Maiti, Tapas K. Singh, N. D. Pradeep |
| author_sort | Jana, Avijit |
| collection | NTU |
| description | We report for the first time the use of perylene-3-ylmethanol fluorescent organic nanoparticles as a drug delivery system. In the present system, perylene-3-ylmethanol nanoparticles performed four important roles: (i) “nanocarriers” for drug delivery; (ii) “phototriggers” for the drug release; (iii) fluorescent chromophores for cell imaging; and (iv) detectors for real time-monitoring of drug release. In vitro biological studies revealed that the newly developed perylene-3-ylmethanol nanoparticles exhibit good biocompatibility and cellular uptake as well as efficient photoregulated anticancer drug release ability. Such fluorescent organic nanoparticles may open up new perspectives for designing a new class of promising photoresponsive nanocarriers for drug delivery. |
| first_indexed | 2024-10-01T07:12:08Z |
| format | Journal Article |
| id | ntu-10356/104213 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:12:08Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/1042132020-03-07T12:34:58Z Perylene-3-ylmethanol : fluorescent organic nanoparticles as a single-component photoresponsive nanocarrier with real-time monitoring of anticancer drug release Jana, Avijit Devi, K. Sanjana P. Maiti, Tapas K. Singh, N. D. Pradeep School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Organic chemistry We report for the first time the use of perylene-3-ylmethanol fluorescent organic nanoparticles as a drug delivery system. In the present system, perylene-3-ylmethanol nanoparticles performed four important roles: (i) “nanocarriers” for drug delivery; (ii) “phototriggers” for the drug release; (iii) fluorescent chromophores for cell imaging; and (iv) detectors for real time-monitoring of drug release. In vitro biological studies revealed that the newly developed perylene-3-ylmethanol nanoparticles exhibit good biocompatibility and cellular uptake as well as efficient photoregulated anticancer drug release ability. Such fluorescent organic nanoparticles may open up new perspectives for designing a new class of promising photoresponsive nanocarriers for drug delivery. 2014-05-22T08:36:13Z 2019-12-06T21:28:30Z 2014-05-22T08:36:13Z 2019-12-06T21:28:30Z 2012 2012 Journal Article Jana, A., Devi, K. S. P., Maiti, T. K., & Singh, N. D. P. (2012).Perylene-3-ylmethanol: Fluorescent Organic Nanoparticles as a Single-Component Photoresponsive Nanocarrier with Real-Time Monitoring of Anticancer Drug Release. Journal of the American Chemical Society, 134 (18), 7656–7659. 0002-7863 https://hdl.handle.net/10356/104213 http://hdl.handle.net/10220/19430 10.1021/ja302482k 172096 en Journal of the American chemical society © 2012 American Chemical Society. |
| spellingShingle | DRNTU::Science::Chemistry::Organic chemistry Jana, Avijit Devi, K. Sanjana P. Maiti, Tapas K. Singh, N. D. Pradeep Perylene-3-ylmethanol : fluorescent organic nanoparticles as a single-component photoresponsive nanocarrier with real-time monitoring of anticancer drug release |
| title | Perylene-3-ylmethanol : fluorescent organic nanoparticles as a single-component photoresponsive nanocarrier with real-time monitoring of anticancer drug release |
| title_full | Perylene-3-ylmethanol : fluorescent organic nanoparticles as a single-component photoresponsive nanocarrier with real-time monitoring of anticancer drug release |
| title_fullStr | Perylene-3-ylmethanol : fluorescent organic nanoparticles as a single-component photoresponsive nanocarrier with real-time monitoring of anticancer drug release |
| title_full_unstemmed | Perylene-3-ylmethanol : fluorescent organic nanoparticles as a single-component photoresponsive nanocarrier with real-time monitoring of anticancer drug release |
| title_short | Perylene-3-ylmethanol : fluorescent organic nanoparticles as a single-component photoresponsive nanocarrier with real-time monitoring of anticancer drug release |
| title_sort | perylene 3 ylmethanol fluorescent organic nanoparticles as a single component photoresponsive nanocarrier with real time monitoring of anticancer drug release |
| topic | DRNTU::Science::Chemistry::Organic chemistry |
| url | https://hdl.handle.net/10356/104213 http://hdl.handle.net/10220/19430 |
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