Poly(N-isopropyl acrylamide) coated magnetite nanoparticles as contrast agents for magnetic resonance imaging
Thermosensitive poly(N-isopropyl acrylamide) (PNIPAM) has been coated on Fe3O4 core to prepare Fe3O4-PNIPAM core–shell nanostructures. The PNIPAM coating has the ability to swell and shrink due to changes in temperature. Core–shell nanostructured samples with different hydrodynamic sizes were prepar...
| Main Authors: | , , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2015
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/104233 http://hdl.handle.net/10220/25973 |
| _version_ | 1826120314135773184 |
|---|---|
| author | Suresh, G. Ramanujan, Raju Vijayaraghavan Chong, T. W. Chaughule, R. S. Pednekar, S. Patkar, D. P. |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Suresh, G. Ramanujan, Raju Vijayaraghavan Chong, T. W. Chaughule, R. S. Pednekar, S. Patkar, D. P. |
| author_sort | Suresh, G. |
| collection | NTU |
| description | Thermosensitive poly(N-isopropyl acrylamide) (PNIPAM) has been coated on Fe3O4 core to prepare Fe3O4-PNIPAM core–shell nanostructures. The PNIPAM coating has the ability to swell and shrink due to changes in temperature. Core–shell nanostructured samples with different hydrodynamic sizes were prepared. Zeta potential measurements showed that these samples are highly stable in aqueous environment. These core–shell structures were shown to be better contrast agents than conventional Gd chelates for magnetic resonance imaging (MRI). Thus this core–shell Fe3O4-PNIPAM system can be used for multimodal theranostics as a drug carrier, hyperthermia agent and for MRI. |
| first_indexed | 2024-10-01T05:14:27Z |
| format | Journal Article |
| id | ntu-10356/104233 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:14:27Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | ntu-10356/1042332020-06-01T10:21:18Z Poly(N-isopropyl acrylamide) coated magnetite nanoparticles as contrast agents for magnetic resonance imaging Suresh, G. Ramanujan, Raju Vijayaraghavan Chong, T. W. Chaughule, R. S. Pednekar, S. Patkar, D. P. School of Materials Science & Engineering DRNTU::Engineering::Materials::Nanostructured materials Thermosensitive poly(N-isopropyl acrylamide) (PNIPAM) has been coated on Fe3O4 core to prepare Fe3O4-PNIPAM core–shell nanostructures. The PNIPAM coating has the ability to swell and shrink due to changes in temperature. Core–shell nanostructured samples with different hydrodynamic sizes were prepared. Zeta potential measurements showed that these samples are highly stable in aqueous environment. These core–shell structures were shown to be better contrast agents than conventional Gd chelates for magnetic resonance imaging (MRI). Thus this core–shell Fe3O4-PNIPAM system can be used for multimodal theranostics as a drug carrier, hyperthermia agent and for MRI. 2015-06-18T06:36:03Z 2019-12-06T21:28:42Z 2015-06-18T06:36:03Z 2019-12-06T21:28:42Z 2015 2015 Journal Article Suresh, G., Ramanujan, R. V., Chong, T. W., Chaughule, R. S., Pednekar, S., & Patkar, D. P. (2015). Poly(N-isopropyl acrylamide) coated magnetite nanoparticles as contrast agents for magnetic resonance imaging. Nanoscience and nanotechnology letters, 7(1), 15-19. https://hdl.handle.net/10356/104233 http://hdl.handle.net/10220/25973 10.1166/nnl.2015.1944 en Nanoscience and nanotechnology letters © 2015 American Scientific Publishers. |
| spellingShingle | DRNTU::Engineering::Materials::Nanostructured materials Suresh, G. Ramanujan, Raju Vijayaraghavan Chong, T. W. Chaughule, R. S. Pednekar, S. Patkar, D. P. Poly(N-isopropyl acrylamide) coated magnetite nanoparticles as contrast agents for magnetic resonance imaging |
| title | Poly(N-isopropyl acrylamide) coated magnetite nanoparticles as contrast agents for magnetic resonance imaging |
| title_full | Poly(N-isopropyl acrylamide) coated magnetite nanoparticles as contrast agents for magnetic resonance imaging |
| title_fullStr | Poly(N-isopropyl acrylamide) coated magnetite nanoparticles as contrast agents for magnetic resonance imaging |
| title_full_unstemmed | Poly(N-isopropyl acrylamide) coated magnetite nanoparticles as contrast agents for magnetic resonance imaging |
| title_short | Poly(N-isopropyl acrylamide) coated magnetite nanoparticles as contrast agents for magnetic resonance imaging |
| title_sort | poly n isopropyl acrylamide coated magnetite nanoparticles as contrast agents for magnetic resonance imaging |
| topic | DRNTU::Engineering::Materials::Nanostructured materials |
| url | https://hdl.handle.net/10356/104233 http://hdl.handle.net/10220/25973 |
| work_keys_str_mv | AT sureshg polynisopropylacrylamidecoatedmagnetitenanoparticlesascontrastagentsformagneticresonanceimaging AT ramanujanrajuvijayaraghavan polynisopropylacrylamidecoatedmagnetitenanoparticlesascontrastagentsformagneticresonanceimaging AT chongtw polynisopropylacrylamidecoatedmagnetitenanoparticlesascontrastagentsformagneticresonanceimaging AT chaughulers polynisopropylacrylamidecoatedmagnetitenanoparticlesascontrastagentsformagneticresonanceimaging AT pednekars polynisopropylacrylamidecoatedmagnetitenanoparticlesascontrastagentsformagneticresonanceimaging AT patkardp polynisopropylacrylamidecoatedmagnetitenanoparticlesascontrastagentsformagneticresonanceimaging |