A facile and fast method for the functionalization of polymersomes by photoinduced cycloaddition chemistry
Polymersomes are promising platforms for use in biosensing, where their stability may be crucial over that of liposomes. For the introduction of the desired functionality multiple strategies have been reported for functionalization of polymersomes. However, none of them have combined readily availab...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/104499 http://hdl.handle.net/10220/16951 |
| _version_ | 1826126007032086528 |
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| author | Nallani, Madhavan Hoog, Hans-Peter M. de Bo, Liedberg |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Nallani, Madhavan Hoog, Hans-Peter M. de Bo, Liedberg |
| author_sort | Nallani, Madhavan |
| collection | NTU |
| description | Polymersomes are promising platforms for use in biosensing, where their stability may be crucial over that of liposomes. For the introduction of the desired functionality multiple strategies have been reported for functionalization of polymersomes. However, none of them have combined readily available starting materials, facility and in situ quantification. We show a simple 4-step method for functionalization of polymersomes starting from commercially available materials. For the key conjugation step a recently explored light induced cycloaddition was used which is relatively fast (15 min) and allows in situ quantification by the intrinsic fluorescence of the conjugate. The facility of the protocol, the ease of preparation and quantification make this ‘click’-type conjugation method a promising alternative to the established strained cycloadditions. |
| first_indexed | 2024-10-01T06:45:42Z |
| format | Journal Article |
| id | ntu-10356/104499 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:45:42Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/1044992020-06-01T10:13:34Z A facile and fast method for the functionalization of polymersomes by photoinduced cycloaddition chemistry Nallani, Madhavan Hoog, Hans-Peter M. de Bo, Liedberg School of Materials Science & Engineering Polymersomes are promising platforms for use in biosensing, where their stability may be crucial over that of liposomes. For the introduction of the desired functionality multiple strategies have been reported for functionalization of polymersomes. However, none of them have combined readily available starting materials, facility and in situ quantification. We show a simple 4-step method for functionalization of polymersomes starting from commercially available materials. For the key conjugation step a recently explored light induced cycloaddition was used which is relatively fast (15 min) and allows in situ quantification by the intrinsic fluorescence of the conjugate. The facility of the protocol, the ease of preparation and quantification make this ‘click’-type conjugation method a promising alternative to the established strained cycloadditions. 2013-10-28T03:10:58Z 2019-12-06T21:34:07Z 2013-10-28T03:10:58Z 2019-12-06T21:34:07Z 2012 2012 Journal Article Hoog, H.-P. M. d., Nallani, M., & Liedberg, B. (2012). A facile and fast method for the functionalization of polymersomes by photoinduced cycloaddition chemistry. Polymer Chemistry, 3(2), 302-306. https://hdl.handle.net/10356/104499 http://hdl.handle.net/10220/16951 10.1039/c1py00413a en Polymer chemistry |
| spellingShingle | Nallani, Madhavan Hoog, Hans-Peter M. de Bo, Liedberg A facile and fast method for the functionalization of polymersomes by photoinduced cycloaddition chemistry |
| title | A facile and fast method for the functionalization of polymersomes by photoinduced cycloaddition chemistry |
| title_full | A facile and fast method for the functionalization of polymersomes by photoinduced cycloaddition chemistry |
| title_fullStr | A facile and fast method for the functionalization of polymersomes by photoinduced cycloaddition chemistry |
| title_full_unstemmed | A facile and fast method for the functionalization of polymersomes by photoinduced cycloaddition chemistry |
| title_short | A facile and fast method for the functionalization of polymersomes by photoinduced cycloaddition chemistry |
| title_sort | facile and fast method for the functionalization of polymersomes by photoinduced cycloaddition chemistry |
| url | https://hdl.handle.net/10356/104499 http://hdl.handle.net/10220/16951 |
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