Zinc-substituted hydroxyapatite : a biomaterial with enhanced bioactivity and antibacterial properties
Hydroxyapatite (HA) is a synthetic biomaterial and has been found to promote new bone formation when implanted in a bone defect site. However, its use is often limited due to its slow osteointegration rate and low antibacterial activity, particularly where HA has to be used for long term biomedical...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/104641 http://hdl.handle.net/10220/16563 |
| _version_ | 1826118500036378624 |
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| author | Thian, E. S. Konishi, T. Kawanobe, Y. Lim, P. N. Ho, B. Aizawa, M. Choong, Cleo Swee Neo |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Thian, E. S. Konishi, T. Kawanobe, Y. Lim, P. N. Ho, B. Aizawa, M. Choong, Cleo Swee Neo |
| author_sort | Thian, E. S. |
| collection | NTU |
| description | Hydroxyapatite (HA) is a synthetic biomaterial and has been found to promote new bone formation when implanted in a bone defect site. However, its use is often limited due to its slow osteointegration rate and low antibacterial activity, particularly where HA has to be used for long term biomedical applications. This work will describe the synthesis and detailed characterization of zinc-substituted HA (ZnHA) as an alternative biomaterial to HA. ZnHA containing 1.6 wt% Zn was synthesized via a co-precipitation reaction between calcium hydroxide, orthophosphoric acid and zinc nitrate hexahydrate. Single-phase ZnHA particles with a rod-like morphology measuring ~50 nm in length and ~15 nm in width, were obtained and characterized using transmission electron microscopy and X-ray diffraction. The substitution of Zn into HA resulted in a decrease in both the a- and c-axes of the unit cell parameters, thereby causing the HA crystal structure to alter. In vitro cell culture work showed that ZnHA possessed enhanced bioactivity since an increase in the growth of human adipose-derived mesenchymal stem cells along with the bone cell differentiation markers, were observed. In addition, antibacterial work demonstrated that ZnHA exhibited antimicrobial capability since there was a significant decrease in the number of viable Staphylococcus aureus bacteria after in contact with ZnHA. |
| first_indexed | 2024-10-01T04:44:25Z |
| format | Journal Article |
| id | ntu-10356/104641 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:44:25Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/1046412020-06-01T10:26:50Z Zinc-substituted hydroxyapatite : a biomaterial with enhanced bioactivity and antibacterial properties Thian, E. S. Konishi, T. Kawanobe, Y. Lim, P. N. Ho, B. Aizawa, M. Choong, Cleo Swee Neo School of Materials Science & Engineering DRNTU::Engineering::Materials Hydroxyapatite (HA) is a synthetic biomaterial and has been found to promote new bone formation when implanted in a bone defect site. However, its use is often limited due to its slow osteointegration rate and low antibacterial activity, particularly where HA has to be used for long term biomedical applications. This work will describe the synthesis and detailed characterization of zinc-substituted HA (ZnHA) as an alternative biomaterial to HA. ZnHA containing 1.6 wt% Zn was synthesized via a co-precipitation reaction between calcium hydroxide, orthophosphoric acid and zinc nitrate hexahydrate. Single-phase ZnHA particles with a rod-like morphology measuring ~50 nm in length and ~15 nm in width, were obtained and characterized using transmission electron microscopy and X-ray diffraction. The substitution of Zn into HA resulted in a decrease in both the a- and c-axes of the unit cell parameters, thereby causing the HA crystal structure to alter. In vitro cell culture work showed that ZnHA possessed enhanced bioactivity since an increase in the growth of human adipose-derived mesenchymal stem cells along with the bone cell differentiation markers, were observed. In addition, antibacterial work demonstrated that ZnHA exhibited antimicrobial capability since there was a significant decrease in the number of viable Staphylococcus aureus bacteria after in contact with ZnHA. 2013-10-17T06:55:00Z 2019-12-06T21:36:45Z 2013-10-17T06:55:00Z 2019-12-06T21:36:45Z 2013 2013 Journal Article Thian, E. S., Konishi, T., Kawanobe, Y., Lim, P. N., Choong, C. S. N., Ho, B., & Aizawa, M. (2013). Zinc-substituted hydroxyapatite : a biomaterial with enhanced bioactivity and antibacterial properties. Journal of materials science : materials in medicine, 24(2), 437-445. https://hdl.handle.net/10356/104641 http://hdl.handle.net/10220/16563 10.1007/s10856-012-4817-x en Journal of materials science : materials in medicine |
| spellingShingle | DRNTU::Engineering::Materials Thian, E. S. Konishi, T. Kawanobe, Y. Lim, P. N. Ho, B. Aizawa, M. Choong, Cleo Swee Neo Zinc-substituted hydroxyapatite : a biomaterial with enhanced bioactivity and antibacterial properties |
| title | Zinc-substituted hydroxyapatite : a biomaterial with enhanced bioactivity and antibacterial properties |
| title_full | Zinc-substituted hydroxyapatite : a biomaterial with enhanced bioactivity and antibacterial properties |
| title_fullStr | Zinc-substituted hydroxyapatite : a biomaterial with enhanced bioactivity and antibacterial properties |
| title_full_unstemmed | Zinc-substituted hydroxyapatite : a biomaterial with enhanced bioactivity and antibacterial properties |
| title_short | Zinc-substituted hydroxyapatite : a biomaterial with enhanced bioactivity and antibacterial properties |
| title_sort | zinc substituted hydroxyapatite a biomaterial with enhanced bioactivity and antibacterial properties |
| topic | DRNTU::Engineering::Materials |
| url | https://hdl.handle.net/10356/104641 http://hdl.handle.net/10220/16563 |
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