Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo
1 μm axial resolution spectral domain optical coherence tomography (OCT) is demonstrated for in vivo cellular resolution imaging. Output of two superluminescent diode sources is combined to provide near infrared illumination from 755 to 1105 nm. The spectral interference is detected using two spectr...
| Main Authors: | , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2015
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/104749 http://hdl.handle.net/10220/24665 |
| _version_ | 1824453190127452160 |
|---|---|
| author | Cui, Dongyao Liu, Xinyu Zhang, Jing Yu, Xiaojun Ding, Sun Luo, Yuemei Gu, Jun Shum, Ping Liu, Linbo |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Cui, Dongyao Liu, Xinyu Zhang, Jing Yu, Xiaojun Ding, Sun Luo, Yuemei Gu, Jun Shum, Ping Liu, Linbo |
| author_sort | Cui, Dongyao |
| collection | NTU |
| description | 1 μm axial resolution spectral domain optical coherence tomography (OCT) is demonstrated for in vivo cellular resolution imaging. Output of two superluminescent diode sources is combined to provide near infrared illumination from 755 to 1105 nm. The spectral interference is detected using two spectrometers based on a Si camera and an InGaAs camera, respectively. Spectra from the two spectrometers are combined to achieve an axial resolution of 1.27 μm in air. Imaging was conducted on zebra fish larvae to visualize cellular details. |
| first_indexed | 2024-10-01T07:56:27Z |
| format | Journal Article |
| id | ntu-10356/104749 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:56:27Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | ntu-10356/1047492020-03-07T11:40:19Z Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo Cui, Dongyao Liu, Xinyu Zhang, Jing Yu, Xiaojun Ding, Sun Luo, Yuemei Gu, Jun Shum, Ping Liu, Linbo School of Chemical and Biomedical Engineering School of Electrical and Electronic Engineering DRNTU::Engineering::Electrical and electronic engineering::Optics, optoelectronics, photonics 1 μm axial resolution spectral domain optical coherence tomography (OCT) is demonstrated for in vivo cellular resolution imaging. Output of two superluminescent diode sources is combined to provide near infrared illumination from 755 to 1105 nm. The spectral interference is detected using two spectrometers based on a Si camera and an InGaAs camera, respectively. Spectra from the two spectrometers are combined to achieve an axial resolution of 1.27 μm in air. Imaging was conducted on zebra fish larvae to visualize cellular details. NMRC (Natl Medical Research Council, S’pore) Accepted version 2015-01-19T08:30:39Z 2019-12-06T21:38:51Z 2015-01-19T08:30:39Z 2019-12-06T21:38:51Z 2014 2014 Journal Article Cui, D., Liu, X., Zhang, J., Yu, X., Ding, S., Luo, Y., et al. (2014). Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo. Optics letters, 39(23), 6727-6730. https://hdl.handle.net/10356/104749 http://hdl.handle.net/10220/24665 10.1364/OL.39.006727 en Optics letters © 2014 Optical Society of America. This is the author created version of a work that has been peer reviewed and accepted for publication by Optics Letters, Optical Society of America. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [Article DOI: http://dx.doi.org/10.1364/OL.39.006727]. application/pdf |
| spellingShingle | DRNTU::Engineering::Electrical and electronic engineering::Optics, optoelectronics, photonics Cui, Dongyao Liu, Xinyu Zhang, Jing Yu, Xiaojun Ding, Sun Luo, Yuemei Gu, Jun Shum, Ping Liu, Linbo Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo |
| title | Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo |
| title_full | Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo |
| title_fullStr | Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo |
| title_full_unstemmed | Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo |
| title_short | Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo |
| title_sort | dual spectrometer system with spectral compounding for 1 μm optical coherence tomography in vivo |
| topic | DRNTU::Engineering::Electrical and electronic engineering::Optics, optoelectronics, photonics |
| url | https://hdl.handle.net/10356/104749 http://hdl.handle.net/10220/24665 |
| work_keys_str_mv | AT cuidongyao dualspectrometersystemwithspectralcompoundingfor1mmopticalcoherencetomographyinvivo AT liuxinyu dualspectrometersystemwithspectralcompoundingfor1mmopticalcoherencetomographyinvivo AT zhangjing dualspectrometersystemwithspectralcompoundingfor1mmopticalcoherencetomographyinvivo AT yuxiaojun dualspectrometersystemwithspectralcompoundingfor1mmopticalcoherencetomographyinvivo AT dingsun dualspectrometersystemwithspectralcompoundingfor1mmopticalcoherencetomographyinvivo AT luoyuemei dualspectrometersystemwithspectralcompoundingfor1mmopticalcoherencetomographyinvivo AT gujun dualspectrometersystemwithspectralcompoundingfor1mmopticalcoherencetomographyinvivo AT shumping dualspectrometersystemwithspectralcompoundingfor1mmopticalcoherencetomographyinvivo AT liulinbo dualspectrometersystemwithspectralcompoundingfor1mmopticalcoherencetomographyinvivo |