Alzheimer’s disease : a panorama glimpse
The single-mutation of genes associated with Alzheimer’s disease (AD) increases the production of Aβ peptides. An elevated concentration of Aβ peptides is prone to aggregation into oligomers and further deposition as plaque. Aβ plaques and neurofibrillary tangles are two hallmarks of AD. In this rev...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2014
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| Online Access: | https://hdl.handle.net/10356/104759 http://hdl.handle.net/10220/20291 |
| _version_ | 1811696519573667840 |
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| author | Zhao, Li Na Mu, Yuguang Lu, Lanyuan Chew, Lock Yue |
| author2 | School of Computer Engineering |
| author_facet | School of Computer Engineering Zhao, Li Na Mu, Yuguang Lu, Lanyuan Chew, Lock Yue |
| author_sort | Zhao, Li Na |
| collection | NTU |
| description | The single-mutation of genes associated with Alzheimer’s disease (AD) increases the production of Aβ peptides. An elevated concentration of Aβ peptides is prone to aggregation into oligomers and further deposition as plaque. Aβ plaques and neurofibrillary tangles are two hallmarks of AD. In this review, we provide a broad overview of the diverses sources that could lead to AD, which include genetic origins, Aβ peptides and tau protein. We shall discuss on tau protein and tau accumulation, which result in neurofibrillary tangles. We detail the mechanisms of Aβ aggregation, fibril formation and its polymorphism. We then show the possible links between Aβ and tau pathology. Furthermore, we summarize the structural data of Aβ and its precursor protein obtained via Nuclear Magnetic Resonance (NMR) or X-ray crystallography. At the end, we go through the C-terminal and N-terminal truncated Aβ variants. We wish to draw reader’s attention to two predominant and toxic Aβ species, namely Aβ4-42 and pyroglutamate amyloid-beta peptides, which have been neglected for more than a decade and may be crucial in Aβ pathogenesis due to their dominant presence in the AD brain. |
| first_indexed | 2024-10-01T07:40:39Z |
| format | Journal Article |
| id | ntu-10356/104759 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:40:39Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/1047592023-02-28T17:04:53Z Alzheimer’s disease : a panorama glimpse Zhao, Li Na Mu, Yuguang Lu, Lanyuan Chew, Lock Yue School of Computer Engineering School of Biological Sciences School of Physical and Mathematical Sciences DRNTU::Science::Biological sciences The single-mutation of genes associated with Alzheimer’s disease (AD) increases the production of Aβ peptides. An elevated concentration of Aβ peptides is prone to aggregation into oligomers and further deposition as plaque. Aβ plaques and neurofibrillary tangles are two hallmarks of AD. In this review, we provide a broad overview of the diverses sources that could lead to AD, which include genetic origins, Aβ peptides and tau protein. We shall discuss on tau protein and tau accumulation, which result in neurofibrillary tangles. We detail the mechanisms of Aβ aggregation, fibril formation and its polymorphism. We then show the possible links between Aβ and tau pathology. Furthermore, we summarize the structural data of Aβ and its precursor protein obtained via Nuclear Magnetic Resonance (NMR) or X-ray crystallography. At the end, we go through the C-terminal and N-terminal truncated Aβ variants. We wish to draw reader’s attention to two predominant and toxic Aβ species, namely Aβ4-42 and pyroglutamate amyloid-beta peptides, which have been neglected for more than a decade and may be crucial in Aβ pathogenesis due to their dominant presence in the AD brain. Published version 2014-08-15T02:39:26Z 2019-12-06T21:39:06Z 2014-08-15T02:39:26Z 2019-12-06T21:39:06Z 2014 2014 Journal Article Zhao, L. N., Lu, L., Chew, L. Y., & Mu, Y. (2014). Alzheimer’s Disease—A Panorama Glimpse. International Journal of Molecular Sciences, 15(7), 12631-12650. 1422-0067 https://hdl.handle.net/10356/104759 http://hdl.handle.net/10220/20291 10.3390/ijms150712631 25032844 en International Journal of Molecular Sciences This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences Zhao, Li Na Mu, Yuguang Lu, Lanyuan Chew, Lock Yue Alzheimer’s disease : a panorama glimpse |
| title | Alzheimer’s disease : a panorama glimpse |
| title_full | Alzheimer’s disease : a panorama glimpse |
| title_fullStr | Alzheimer’s disease : a panorama glimpse |
| title_full_unstemmed | Alzheimer’s disease : a panorama glimpse |
| title_short | Alzheimer’s disease : a panorama glimpse |
| title_sort | alzheimer s disease a panorama glimpse |
| topic | DRNTU::Science::Biological sciences |
| url | https://hdl.handle.net/10356/104759 http://hdl.handle.net/10220/20291 |
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