Pseudomonas aeruginosa dose response and bathing water infection
Pseudomonas aeruginosa is the opportunistic pathogen mostly implicated in folliculitis and acute otitis externa in pools and hot tubs. Nevertheless, infection risks remain poorly quantified. This paper reviews disease aetiologies and bacterial skin colonization science to advance dose-response theor...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2014
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| Online Access: | https://hdl.handle.net/10356/105031 http://hdl.handle.net/10220/20386 |
| _version_ | 1811678969937788928 |
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| author | Roser, D. J. Rice, S. A. Ashbolt, N. J. Haas, C. N. Boase, S. Van Den Akker, B. |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Roser, D. J. Rice, S. A. Ashbolt, N. J. Haas, C. N. Boase, S. Van Den Akker, B. |
| author_sort | Roser, D. J. |
| collection | NTU |
| description | Pseudomonas aeruginosa is the opportunistic pathogen mostly implicated in folliculitis and acute otitis externa in pools and hot tubs. Nevertheless, infection risks remain poorly quantified. This paper reviews disease aetiologies and bacterial skin colonization science to advance dose-response theory development. Three model forms are identified for predicting disease likelihood from pathogen density. Two are based on Furumoto & Mickey's exponential ‘single-hit’ model and predict infection likelihood and severity (lesions/m2), respectively. ‘Third-generation’, mechanistic, dose-response algorithm development is additionally scoped. The proposed formulation integrates dispersion, epidermal interaction, and follicle invasion. The review also details uncertainties needing consideration which pertain to water quality, outbreaks, exposure time, infection sites, biofilms, cerumen, environmental factors (e.g. skin saturation, hydrodynamics), and whether P. aeruginosa is endogenous or exogenous. The review's findings are used to propose a conceptual infection model and identify research priorities including pool dose-response modelling, epidermis ecology and infection likelihood-based hygiene management. |
| first_indexed | 2024-10-01T03:01:43Z |
| format | Journal Article |
| id | ntu-10356/105031 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:01:43Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/1050312020-09-21T11:32:13Z Pseudomonas aeruginosa dose response and bathing water infection Roser, D. J. Rice, S. A. Ashbolt, N. J. Haas, C. N. Boase, S. Van Den Akker, B. School of Biological Sciences Singapore Centre for Environmental Life Sciences Engineering DRNTU::Science::Biological sciences::Molecular biology Pseudomonas aeruginosa is the opportunistic pathogen mostly implicated in folliculitis and acute otitis externa in pools and hot tubs. Nevertheless, infection risks remain poorly quantified. This paper reviews disease aetiologies and bacterial skin colonization science to advance dose-response theory development. Three model forms are identified for predicting disease likelihood from pathogen density. Two are based on Furumoto & Mickey's exponential ‘single-hit’ model and predict infection likelihood and severity (lesions/m2), respectively. ‘Third-generation’, mechanistic, dose-response algorithm development is additionally scoped. The proposed formulation integrates dispersion, epidermal interaction, and follicle invasion. The review also details uncertainties needing consideration which pertain to water quality, outbreaks, exposure time, infection sites, biofilms, cerumen, environmental factors (e.g. skin saturation, hydrodynamics), and whether P. aeruginosa is endogenous or exogenous. The review's findings are used to propose a conceptual infection model and identify research priorities including pool dose-response modelling, epidermis ecology and infection likelihood-based hygiene management. Published version 2014-08-25T01:40:04Z 2019-12-06T21:44:45Z 2014-08-25T01:40:04Z 2019-12-06T21:44:45Z 2013 2013 Journal Article Roser, D. J., Van Den Akker, B., Boase, S., Haas, C. N., Ashbolt, N. J., & Rice, S. A. (2014). Pseudomonas aeruginosa dose response and bathing water infection. Epidemiology and Infection, 142(03), 449-462. 0950-2688 https://hdl.handle.net/10356/105031 http://hdl.handle.net/10220/20386 10.1017/S0950268813002690 en Epidemiology and infection © 2013 Cambridge University Press. This paper was published in Epidemiology and Infection and is made available as an electronic reprint (preprint) with permission of Cambridge University Press. The paper can be found at the following official DOI: http://dx.doi.org/10.1017/S0950268813002690. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences::Molecular biology Roser, D. J. Rice, S. A. Ashbolt, N. J. Haas, C. N. Boase, S. Van Den Akker, B. Pseudomonas aeruginosa dose response and bathing water infection |
| title | Pseudomonas aeruginosa dose response and bathing water infection |
| title_full | Pseudomonas aeruginosa dose response and bathing water infection |
| title_fullStr | Pseudomonas aeruginosa dose response and bathing water infection |
| title_full_unstemmed | Pseudomonas aeruginosa dose response and bathing water infection |
| title_short | Pseudomonas aeruginosa dose response and bathing water infection |
| title_sort | pseudomonas aeruginosa dose response and bathing water infection |
| topic | DRNTU::Science::Biological sciences::Molecular biology |
| url | https://hdl.handle.net/10356/105031 http://hdl.handle.net/10220/20386 |
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