Drug encapsulation and release by mesoporous silica nanoparticles : the effect of surface functional groups
Mesoporous silica nanoparticles (MSNPs) have been widely used as drug carriers for stimuli-responsive drug delivery. Herein, a catalysis screening technique was adopted for analyzing the effects of chain length, terminal group, and density of disulfide-appended functional ligands on the surface of M...
| Үндсэн зохиолчид: | , , , , |
|---|---|
| Бусад зохиолчид: | |
| Формат: | Journal Article |
| Хэл сонгох: | English |
| Хэвлэсэн: |
2014
|
| Нөхцлүүд: | |
| Онлайн хандалт: | https://hdl.handle.net/10356/105151 http://hdl.handle.net/10220/20483 |
| _version_ | 1826123587321331712 |
|---|---|
| author | Tan, Si Yu Ang, Chung Yen Li, Peizhou Yap, Qi Ming Zhao, Yanli |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Tan, Si Yu Ang, Chung Yen Li, Peizhou Yap, Qi Ming Zhao, Yanli |
| author_sort | Tan, Si Yu |
| collection | NTU |
| description | Mesoporous silica nanoparticles (MSNPs) have been widely used as drug carriers for stimuli-responsive drug delivery. Herein, a catalysis screening technique was adopted for analyzing the effects of chain length, terminal group, and density of disulfide-appended functional ligands on the surface of MSNPs on drug-loading capacity and glutathione-triggered drug-release kinetics. The ligand with an intermediate length (5 carbon atoms) and a bulky terminal group (cyclohexyl) that complexes with theβ-cyclodextrin ring showed the highest drug loading capacity as well as good release kinetics. In addition, decreasing the surface coverage of the functional ligands led to an enhancement in drug release. In vitro drug-delivery experiments on a melanoma cell line (B16-F10) by using the functionalized MSNPs further supported the conclusion. The results obtained may serve as a general guide for developing more effective MSNP systems for drug delivery. |
| first_indexed | 2024-10-01T06:07:05Z |
| format | Journal Article |
| id | ntu-10356/105151 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:07:05Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/1051512020-06-01T10:01:51Z Drug encapsulation and release by mesoporous silica nanoparticles : the effect of surface functional groups Tan, Si Yu Ang, Chung Yen Li, Peizhou Yap, Qi Ming Zhao, Yanli School of Materials Science & Engineering School of Physical and Mathematical Sciences DRNTU::Science::Chemistry Mesoporous silica nanoparticles (MSNPs) have been widely used as drug carriers for stimuli-responsive drug delivery. Herein, a catalysis screening technique was adopted for analyzing the effects of chain length, terminal group, and density of disulfide-appended functional ligands on the surface of MSNPs on drug-loading capacity and glutathione-triggered drug-release kinetics. The ligand with an intermediate length (5 carbon atoms) and a bulky terminal group (cyclohexyl) that complexes with theβ-cyclodextrin ring showed the highest drug loading capacity as well as good release kinetics. In addition, decreasing the surface coverage of the functional ligands led to an enhancement in drug release. In vitro drug-delivery experiments on a melanoma cell line (B16-F10) by using the functionalized MSNPs further supported the conclusion. The results obtained may serve as a general guide for developing more effective MSNP systems for drug delivery. 2014-09-10T06:17:27Z 2019-12-06T21:46:34Z 2014-09-10T06:17:27Z 2019-12-06T21:46:34Z 2014 2014 Journal Article Tan, S. Y., Ang, C. Y., Li, P., Yap, Q. M., & Zhao, Y. (2014). Drug Encapsulation and Release by Mesoporous Silica Nanoparticles: The Effect of Surface Functional Groups. Chemistry - A European Journal, 20(36), 11276-11282. 0947-6539 https://hdl.handle.net/10356/105151 http://hdl.handle.net/10220/20483 10.1002/chem.201403551 en Chemistry - a European journal © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| spellingShingle | DRNTU::Science::Chemistry Tan, Si Yu Ang, Chung Yen Li, Peizhou Yap, Qi Ming Zhao, Yanli Drug encapsulation and release by mesoporous silica nanoparticles : the effect of surface functional groups |
| title | Drug encapsulation and release by mesoporous silica nanoparticles : the effect of surface functional groups |
| title_full | Drug encapsulation and release by mesoporous silica nanoparticles : the effect of surface functional groups |
| title_fullStr | Drug encapsulation and release by mesoporous silica nanoparticles : the effect of surface functional groups |
| title_full_unstemmed | Drug encapsulation and release by mesoporous silica nanoparticles : the effect of surface functional groups |
| title_short | Drug encapsulation and release by mesoporous silica nanoparticles : the effect of surface functional groups |
| title_sort | drug encapsulation and release by mesoporous silica nanoparticles the effect of surface functional groups |
| topic | DRNTU::Science::Chemistry |
| url | https://hdl.handle.net/10356/105151 http://hdl.handle.net/10220/20483 |
| work_keys_str_mv | AT tansiyu drugencapsulationandreleasebymesoporoussilicananoparticlestheeffectofsurfacefunctionalgroups AT angchungyen drugencapsulationandreleasebymesoporoussilicananoparticlestheeffectofsurfacefunctionalgroups AT lipeizhou drugencapsulationandreleasebymesoporoussilicananoparticlestheeffectofsurfacefunctionalgroups AT yapqiming drugencapsulationandreleasebymesoporoussilicananoparticlestheeffectofsurfacefunctionalgroups AT zhaoyanli drugencapsulationandreleasebymesoporoussilicananoparticlestheeffectofsurfacefunctionalgroups |