Orthogonally engineering matrix topography and rigidity to regulate multicellular morphology

Programmable polymer substrates, which mimic the variable extracellular matrices in living systems, are used to regulate multicellular morphology, via orthogonally modulating the matrix topography and elasticity. The multicellular morphology is dependent on the competition between cell–matrix adhesi...

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Detalhes bibliográficos
Principais autores: Hu, Benhui, Shi, Wenxiong, Wu, Yun-Long, Leow, Wan Ru, Cai, Pingqiang, Li, Shuzhou, Chen, Xiaodong
Outros Autores: School of Materials Science & Engineering
Formato: Journal Article
Idioma:English
Publicado em: 2014
Assuntos:
Acesso em linha:https://hdl.handle.net/10356/105186
http://hdl.handle.net/10220/20499
Descrição
Resumo:Programmable polymer substrates, which mimic the variable extracellular matrices in living systems, are used to regulate multicellular morphology, via orthogonally modulating the matrix topography and elasticity. The multicellular morphology is dependent on the competition between cell–matrix adhesion and cell–cell adhesion. Decreasing the cell–matrix adhesion provokes cytoskeleton reorganization, inhibits lamellipodial crawling, and thus enhances the leakiness of multicellular morphology.