Near-infrared light responsive multi-compartmental hydrogel particles synthesized through droplets assembly induced by superhydrophobic surface
Light-responsive hydrogel particles with multi-compartmental structure are useful for applications in microreactors, drug delivery and tissue engineering because of their remotely-triggerable releasing ability and combinational functionalities. The current methods of synthesizing multi-compartmental...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/105317 http://hdl.handle.net/10220/20700 |
| _version_ | 1811688126124392448 |
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| author | Luo, Rongcong Cao, Ye Shi, Peng Chen, Chia-Hung |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Luo, Rongcong Cao, Ye Shi, Peng Chen, Chia-Hung |
| author_sort | Luo, Rongcong |
| collection | NTU |
| description | Light-responsive hydrogel particles with multi-compartmental structure are useful for applications in microreactors, drug delivery and tissue engineering because of their remotely-triggerable releasing ability and combinational functionalities. The current methods of synthesizing multi-compartmental hydrogel particles typically involve multi-step interrupted gelation of polysaccharides or complicated microfluidic procedures with limited throughput. In this study, a two-step sequential gelation process is developed to produce agarose/alginate double network multi-compartmental hydrogel particles using droplets assemblies induced by superhydrophobic surface as templates. The agarose/alginate double network multi-compartmental hydrogel particles can be formed with diverse hierarchical structures showing combinational functionalities. The synthesized hydrogel particles, when loaded with polypyrrole (PPy) nanoparticles that act as photothermal nanotransducers, are demonstrated to function as near-infrared (NIR) light triggerable and deformation-free hydrogel materials. Periodic NIR laser switching is applied to stimulate these hydrogel particles, and pulsatile release profiles are collected. Compared with massive reagents released from single-compartmental hydrogel particles, more regulated release profiles of the multi-compartmental hydrogel particles are observed. |
| first_indexed | 2024-10-01T05:27:15Z |
| format | Journal Article |
| id | ntu-10356/105317 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:27:15Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/1053172020-06-01T10:21:10Z Near-infrared light responsive multi-compartmental hydrogel particles synthesized through droplets assembly induced by superhydrophobic surface Luo, Rongcong Cao, Ye Shi, Peng Chen, Chia-Hung School of Materials Science & Engineering DRNTU::Science Light-responsive hydrogel particles with multi-compartmental structure are useful for applications in microreactors, drug delivery and tissue engineering because of their remotely-triggerable releasing ability and combinational functionalities. The current methods of synthesizing multi-compartmental hydrogel particles typically involve multi-step interrupted gelation of polysaccharides or complicated microfluidic procedures with limited throughput. In this study, a two-step sequential gelation process is developed to produce agarose/alginate double network multi-compartmental hydrogel particles using droplets assemblies induced by superhydrophobic surface as templates. The agarose/alginate double network multi-compartmental hydrogel particles can be formed with diverse hierarchical structures showing combinational functionalities. The synthesized hydrogel particles, when loaded with polypyrrole (PPy) nanoparticles that act as photothermal nanotransducers, are demonstrated to function as near-infrared (NIR) light triggerable and deformation-free hydrogel materials. Periodic NIR laser switching is applied to stimulate these hydrogel particles, and pulsatile release profiles are collected. Compared with massive reagents released from single-compartmental hydrogel particles, more regulated release profiles of the multi-compartmental hydrogel particles are observed. 2014-09-15T07:39:07Z 2019-12-06T21:49:05Z 2014-09-15T07:39:07Z 2019-12-06T21:49:05Z 2014 2014 Journal Article Luo, R., Cao, Y., Shi, P., & Chen, C.-H. (2014). Near-infrared light responsive multi-compartmental hydrogel particles synthesized through droplets assembly induced by superhydrophobic surface. Small, 10(23), 4886-4894. 1613-6810 https://hdl.handle.net/10356/105317 http://hdl.handle.net/10220/20700 10.1002/smll.201401312 en Small © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| spellingShingle | DRNTU::Science Luo, Rongcong Cao, Ye Shi, Peng Chen, Chia-Hung Near-infrared light responsive multi-compartmental hydrogel particles synthesized through droplets assembly induced by superhydrophobic surface |
| title | Near-infrared light responsive multi-compartmental hydrogel particles synthesized through droplets assembly induced by superhydrophobic surface |
| title_full | Near-infrared light responsive multi-compartmental hydrogel particles synthesized through droplets assembly induced by superhydrophobic surface |
| title_fullStr | Near-infrared light responsive multi-compartmental hydrogel particles synthesized through droplets assembly induced by superhydrophobic surface |
| title_full_unstemmed | Near-infrared light responsive multi-compartmental hydrogel particles synthesized through droplets assembly induced by superhydrophobic surface |
| title_short | Near-infrared light responsive multi-compartmental hydrogel particles synthesized through droplets assembly induced by superhydrophobic surface |
| title_sort | near infrared light responsive multi compartmental hydrogel particles synthesized through droplets assembly induced by superhydrophobic surface |
| topic | DRNTU::Science |
| url | https://hdl.handle.net/10356/105317 http://hdl.handle.net/10220/20700 |
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