Permeability and viscoelastic fracture of a model tumor under interstitial flow
Interstitial flow in tumors is a key mechanism leading to cancer metastasis. Tumor growth is accompanied by the development of a leaky vasculature, which increases intratumoral pressure and generates an outward interstitial flow. This flow promotes tumor cell migration away from the tumor. The natur...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2019
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| Online Access: | https://hdl.handle.net/10356/105581 http://hdl.handle.net/10220/50143 |
| _version_ | 1811692571799322624 |
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| author | Tran, Quang D. Marcos Gonzalez-Rodriguez, David |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Tran, Quang D. Marcos Gonzalez-Rodriguez, David |
| author_sort | Tran, Quang D. |
| collection | NTU |
| description | Interstitial flow in tumors is a key mechanism leading to cancer metastasis. Tumor growth is accompanied by the development of a leaky vasculature, which increases intratumoral pressure and generates an outward interstitial flow. This flow promotes tumor cell migration away from the tumor. The nature of such interstitial flow depends on the coupling between hydrodynamic conditions and material properties of the tumor, such as porosity and deformability. Here we investigate this coupling by means of a microfluidic model of interstitial flow through a tumor, which is represented by a tumor cell aggregate. For a weak intratumoral pressure, the model tumor behaves as a viscoelastic material of low permeability, which we estimate by means of a newly developed microfluidic device. As intratumoral pressure is raised, the model tumor deforms and its permeability increases. For a high enough pressure, localized intratumoral fracture occurs, which creates preferential flow paths and causes tumor cell detachment. The energy required to fracture depends on the rate of variation of intratumoral pressure, as explained here by a theoretical model originally derived to describe polymer adhesion. Besides the well-established picture of individual tumor cells migrating away under interstitial flow, our findings suggest that intratumoral pressures observed in tumors can suffice to detach tumor fragments, which may thus be an important mechanism to release cancer cells and initiate metastasis. |
| first_indexed | 2024-10-01T06:37:54Z |
| format | Journal Article |
| id | ntu-10356/105581 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:37:54Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | ntu-10356/1055812023-03-04T17:20:24Z Permeability and viscoelastic fracture of a model tumor under interstitial flow Tran, Quang D. Marcos Gonzalez-Rodriguez, David School of Mechanical and Aerospace Engineering Engineering::Mechanical engineering Permeability Tumor Interstitial flow in tumors is a key mechanism leading to cancer metastasis. Tumor growth is accompanied by the development of a leaky vasculature, which increases intratumoral pressure and generates an outward interstitial flow. This flow promotes tumor cell migration away from the tumor. The nature of such interstitial flow depends on the coupling between hydrodynamic conditions and material properties of the tumor, such as porosity and deformability. Here we investigate this coupling by means of a microfluidic model of interstitial flow through a tumor, which is represented by a tumor cell aggregate. For a weak intratumoral pressure, the model tumor behaves as a viscoelastic material of low permeability, which we estimate by means of a newly developed microfluidic device. As intratumoral pressure is raised, the model tumor deforms and its permeability increases. For a high enough pressure, localized intratumoral fracture occurs, which creates preferential flow paths and causes tumor cell detachment. The energy required to fracture depends on the rate of variation of intratumoral pressure, as explained here by a theoretical model originally derived to describe polymer adhesion. Besides the well-established picture of individual tumor cells migrating away under interstitial flow, our findings suggest that intratumoral pressures observed in tumors can suffice to detach tumor fragments, which may thus be an important mechanism to release cancer cells and initiate metastasis. Accepted version 2019-10-11T08:55:08Z 2019-12-06T21:53:56Z 2019-10-11T08:55:08Z 2019-12-06T21:53:56Z 2018 Journal Article Tran, Q. D., Marcos & Gonzalez-Rodriguez, D. (2018). Permeability and viscoelastic fracture of a model tumor under interstitial flow. Soft Matter, 14(30), 6386-6392. doi:10.1039/C8SM00844B 1744-683X https://hdl.handle.net/10356/105581 http://hdl.handle.net/10220/50143 10.1039/C8SM00844B en Soft Matter © 2018 The Royal Society of Chemistry. All rights reserved. This paper was published in Soft Matter and is made available with permission of The Royal Society of Chemistry. 8 p. application/pdf |
| spellingShingle | Engineering::Mechanical engineering Permeability Tumor Tran, Quang D. Marcos Gonzalez-Rodriguez, David Permeability and viscoelastic fracture of a model tumor under interstitial flow |
| title | Permeability and viscoelastic fracture of a model tumor under interstitial flow |
| title_full | Permeability and viscoelastic fracture of a model tumor under interstitial flow |
| title_fullStr | Permeability and viscoelastic fracture of a model tumor under interstitial flow |
| title_full_unstemmed | Permeability and viscoelastic fracture of a model tumor under interstitial flow |
| title_short | Permeability and viscoelastic fracture of a model tumor under interstitial flow |
| title_sort | permeability and viscoelastic fracture of a model tumor under interstitial flow |
| topic | Engineering::Mechanical engineering Permeability Tumor |
| url | https://hdl.handle.net/10356/105581 http://hdl.handle.net/10220/50143 |
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