Postmortem evidence of disseminated Zika virus infection in an adult patient
Fatal complications associated with the Zika virus (ZIKV) have rarely been reported in adults, and detailed postmortem reports are limited (Musso and Gubler, 2016). ZIKV infection is typically a mild uncomplicated febrile illness associated with arthralgia, rash, and conjunctivitis (Duffy et al., 20...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2019
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| Online Access: | https://hdl.handle.net/10356/105746 http://hdl.handle.net/10220/48735 |
| _version_ | 1811689126099943424 |
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| author | Rajahram, Giri Shan Hale, Gillian Bhatnagar, Julu Hiu, Jessie Thayan, Ravindran William, Timothy Wong, Kum Thong Tambyah, Paul Anantharajah Yeo, Tsin Wen |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Rajahram, Giri Shan Hale, Gillian Bhatnagar, Julu Hiu, Jessie Thayan, Ravindran William, Timothy Wong, Kum Thong Tambyah, Paul Anantharajah Yeo, Tsin Wen |
| author_sort | Rajahram, Giri Shan |
| collection | NTU |
| description | Fatal complications associated with the Zika virus (ZIKV) have rarely been reported in adults, and detailed postmortem reports are limited (Musso and Gubler, 2016). ZIKV infection is typically a mild uncomplicated febrile illness associated with arthralgia, rash, and conjunctivitis (Duffy et al., 2009). In adults, fatal and non-fatal neurological complications have been reported, including encephalitis and Guillain–Barré syndrome (Soares et al., 2016, Oehler et al., 2014). Non-neurological fatalities have also been reported sporadically in patients from Latin America, who have presented with an acute febrile illness and multi-organ failure (Sarmiento-Ospina et al., 2016, Zonneveld et al., 2016). This report describes the clinical features and postmortem findings of a 61-year-old Malaysian male with co-morbidities, who had a fatal outcome subsequent to an acute febrile and rash illness, with pre- and postmortem evidence of ZIKV infection. |
| first_indexed | 2024-10-01T05:43:08Z |
| format | Journal Article |
| id | ntu-10356/105746 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:43:08Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | ntu-10356/1057462020-11-01T05:21:31Z Postmortem evidence of disseminated Zika virus infection in an adult patient Rajahram, Giri Shan Hale, Gillian Bhatnagar, Julu Hiu, Jessie Thayan, Ravindran William, Timothy Wong, Kum Thong Tambyah, Paul Anantharajah Yeo, Tsin Wen Lee Kong Chian School of Medicine (LKCMedicine) Viruses ZIKV Infections DRNTU::Science::Medicine Fatal complications associated with the Zika virus (ZIKV) have rarely been reported in adults, and detailed postmortem reports are limited (Musso and Gubler, 2016). ZIKV infection is typically a mild uncomplicated febrile illness associated with arthralgia, rash, and conjunctivitis (Duffy et al., 2009). In adults, fatal and non-fatal neurological complications have been reported, including encephalitis and Guillain–Barré syndrome (Soares et al., 2016, Oehler et al., 2014). Non-neurological fatalities have also been reported sporadically in patients from Latin America, who have presented with an acute febrile illness and multi-organ failure (Sarmiento-Ospina et al., 2016, Zonneveld et al., 2016). This report describes the clinical features and postmortem findings of a 61-year-old Malaysian male with co-morbidities, who had a fatal outcome subsequent to an acute febrile and rash illness, with pre- and postmortem evidence of ZIKV infection. Published version 2019-06-13T08:06:36Z 2019-12-06T21:57:08Z 2019-06-13T08:06:36Z 2019-12-06T21:57:08Z 2019 Journal Article Rajahram, G. S., Hale, G., Bhatnagar, J., Hiu, J., Thayan, R., William, T., . . . Yeo, T. W. (2019). Postmortem evidence of disseminated Zika virus infection in an adult patient. International Journal of Infectious Diseases, 83, 163-166. doi:10.1016/j.ijid.2019.01.047 1201-9712 https://hdl.handle.net/10356/105746 http://hdl.handle.net/10220/48735 10.1016/j.ijid.2019.01.047 en International Journal of Infectious Diseases © 2019 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CCBY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). 4 p. application/pdf |
| spellingShingle | Viruses ZIKV Infections DRNTU::Science::Medicine Rajahram, Giri Shan Hale, Gillian Bhatnagar, Julu Hiu, Jessie Thayan, Ravindran William, Timothy Wong, Kum Thong Tambyah, Paul Anantharajah Yeo, Tsin Wen Postmortem evidence of disseminated Zika virus infection in an adult patient |
| title | Postmortem evidence of disseminated Zika virus infection in an adult patient |
| title_full | Postmortem evidence of disseminated Zika virus infection in an adult patient |
| title_fullStr | Postmortem evidence of disseminated Zika virus infection in an adult patient |
| title_full_unstemmed | Postmortem evidence of disseminated Zika virus infection in an adult patient |
| title_short | Postmortem evidence of disseminated Zika virus infection in an adult patient |
| title_sort | postmortem evidence of disseminated zika virus infection in an adult patient |
| topic | Viruses ZIKV Infections DRNTU::Science::Medicine |
| url | https://hdl.handle.net/10356/105746 http://hdl.handle.net/10220/48735 |
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