β-Carbon activation of saturated carboxylic esters through N-heterocyclic carbene organocatalysis
The activation of the α-carbons of carboxylic esters and related carbonyl compounds to generate enolate equivalents as nucleophiles is one of the most powerful strategies in organic synthesis. We reasoned that the horizons of chemical synthesis could be greatly expanded if the typically inert β-carb...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/105761 http://hdl.handle.net/10220/17073 http://dx.doi.org/10.1038/nchem.1710 |