“Smart” theranostic lanthanide nanoprobes with simultaneous up-conversion fluorescence and tunable T1–T2 magnetic resonance imaging contrast and near-infrared activated photodynamic therapy
The current work reports a type of “smart” lanthanide-based theranostic nanoprobe, NaDyF4:Yb3+/NaGdF4:Yb3+,Er3+, which is able to circumvent the up-converting poisoning effect of Dy3+ ions to give efficient near infrared (980 nm) triggered up-conversion fluorescence, and offers not only excellent da...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2014
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| Online Access: | https://hdl.handle.net/10356/105838 http://hdl.handle.net/10220/20951 |
| _version_ | 1811695824805036032 |
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| author | Zhang, Yan Das, Gautom Kumar Vijayaragavan, Vimalan Xu, Qing Chi Padmanabhan, Parasuraman Bhakoo, Kishore K. Tamil Selvan, Subramanian Tan, Timothy Thatt Yang |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Zhang, Yan Das, Gautom Kumar Vijayaragavan, Vimalan Xu, Qing Chi Padmanabhan, Parasuraman Bhakoo, Kishore K. Tamil Selvan, Subramanian Tan, Timothy Thatt Yang |
| author_sort | Zhang, Yan |
| collection | NTU |
| description | The current work reports a type of “smart” lanthanide-based theranostic nanoprobe, NaDyF4:Yb3+/NaGdF4:Yb3+,Er3+, which is able to circumvent the up-converting poisoning effect of Dy3+ ions to give efficient near infrared (980 nm) triggered up-conversion fluorescence, and offers not only excellent dark T2-weighted MR contrast but also tunable bright and T1-weighted MR contrast properties. Due to the efficient up-converted energy transfer from the nanocrystals to chlorin e6 (Ce6) photosensitizers loaded onto the nanocrystals, cytotoxic singlet oxygen was generated and photodynamic therapy was demonstrated. Therefore, the current multifunctional nanocrystals could be potentially useful in various image-guided diagnoses where bright or dark MRI contrast could be selectively tuned to optimize image quality, but also as an efficient and more penetrative near-infrared activated photodynamic therapy agent. |
| first_indexed | 2024-10-01T07:29:37Z |
| format | Journal Article |
| id | ntu-10356/105838 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:29:37Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/1058382020-11-01T05:28:08Z “Smart” theranostic lanthanide nanoprobes with simultaneous up-conversion fluorescence and tunable T1–T2 magnetic resonance imaging contrast and near-infrared activated photodynamic therapy Zhang, Yan Das, Gautom Kumar Vijayaragavan, Vimalan Xu, Qing Chi Padmanabhan, Parasuraman Bhakoo, Kishore K. Tamil Selvan, Subramanian Tan, Timothy Thatt Yang Lee Kong Chian School of Medicine (LKCMedicine) School of Chemical and Biomedical Engineering DRNTU::Science::Physics The current work reports a type of “smart” lanthanide-based theranostic nanoprobe, NaDyF4:Yb3+/NaGdF4:Yb3+,Er3+, which is able to circumvent the up-converting poisoning effect of Dy3+ ions to give efficient near infrared (980 nm) triggered up-conversion fluorescence, and offers not only excellent dark T2-weighted MR contrast but also tunable bright and T1-weighted MR contrast properties. Due to the efficient up-converted energy transfer from the nanocrystals to chlorin e6 (Ce6) photosensitizers loaded onto the nanocrystals, cytotoxic singlet oxygen was generated and photodynamic therapy was demonstrated. Therefore, the current multifunctional nanocrystals could be potentially useful in various image-guided diagnoses where bright or dark MRI contrast could be selectively tuned to optimize image quality, but also as an efficient and more penetrative near-infrared activated photodynamic therapy agent. Published version 2014-09-22T08:50:40Z 2019-12-06T21:59:02Z 2014-09-22T08:50:40Z 2019-12-06T21:59:02Z 2014 2014 Journal Article Zhang, Y., Das, G. K., Vijayaragavan, V., Xu, Q. C., Padmanabhan, P., Bhakoo, K. K., et al. (2014). “Smart” theranostic lanthanide nanoprobes with simultaneous up-conversion fluorescence and tunable T1–T2 magnetic resonance imaging contrast and near-infrared activated photodynamic therapy. Nanoscale, 6(21), 12609-12617. https://hdl.handle.net/10356/105838 http://hdl.handle.net/10220/20951 10.1039/C4NR01717J en Nanoscale This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. 9 p. application/pdf |
| spellingShingle | DRNTU::Science::Physics Zhang, Yan Das, Gautom Kumar Vijayaragavan, Vimalan Xu, Qing Chi Padmanabhan, Parasuraman Bhakoo, Kishore K. Tamil Selvan, Subramanian Tan, Timothy Thatt Yang “Smart” theranostic lanthanide nanoprobes with simultaneous up-conversion fluorescence and tunable T1–T2 magnetic resonance imaging contrast and near-infrared activated photodynamic therapy |
| title | “Smart” theranostic lanthanide nanoprobes with simultaneous up-conversion fluorescence and tunable T1–T2 magnetic resonance imaging contrast and near-infrared activated photodynamic therapy |
| title_full | “Smart” theranostic lanthanide nanoprobes with simultaneous up-conversion fluorescence and tunable T1–T2 magnetic resonance imaging contrast and near-infrared activated photodynamic therapy |
| title_fullStr | “Smart” theranostic lanthanide nanoprobes with simultaneous up-conversion fluorescence and tunable T1–T2 magnetic resonance imaging contrast and near-infrared activated photodynamic therapy |
| title_full_unstemmed | “Smart” theranostic lanthanide nanoprobes with simultaneous up-conversion fluorescence and tunable T1–T2 magnetic resonance imaging contrast and near-infrared activated photodynamic therapy |
| title_short | “Smart” theranostic lanthanide nanoprobes with simultaneous up-conversion fluorescence and tunable T1–T2 magnetic resonance imaging contrast and near-infrared activated photodynamic therapy |
| title_sort | smart theranostic lanthanide nanoprobes with simultaneous up conversion fluorescence and tunable t1 t2 magnetic resonance imaging contrast and near infrared activated photodynamic therapy |
| topic | DRNTU::Science::Physics |
| url | https://hdl.handle.net/10356/105838 http://hdl.handle.net/10220/20951 |
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