Metabolizable semiconducting polymer nanoparticles for second near-infrared photoacoustic imaging
Photoacoustic (PA) imaging in the second near‐infrared (NIR‐II) window (1000–1700 nm) holds great promise for deep‐tissue diagnosis due to the reduced light scattering and minimized tissue absorption; however, exploration of such a noninvasive imaging technique is greatly constrained by the lack of...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2019
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| Online Access: | https://hdl.handle.net/10356/105841 http://hdl.handle.net/10220/48854 |
| _version_ | 1826119306269687808 |
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| author | Jiang, Yuyan Upputuri, Paul Kumar Xie, Chen Zeng, Ziling Sharma, Arunima Zhen, Xu Li, Jingchao Huang, Jiaguo Pramanik, Manojit Pu, Kanyi |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Jiang, Yuyan Upputuri, Paul Kumar Xie, Chen Zeng, Ziling Sharma, Arunima Zhen, Xu Li, Jingchao Huang, Jiaguo Pramanik, Manojit Pu, Kanyi |
| author_sort | Jiang, Yuyan |
| collection | NTU |
| description | Photoacoustic (PA) imaging in the second near‐infrared (NIR‐II) window (1000–1700 nm) holds great promise for deep‐tissue diagnosis due to the reduced light scattering and minimized tissue absorption; however, exploration of such a noninvasive imaging technique is greatly constrained by the lack of biodegradable NIR‐II absorbing agents. Herein, the first series of metabolizable NIR‐II PA agents are reported based on semiconducting polymer nanoparticles (SPNs). Such completely organic nanoagents consist of π‐conjugated yet oxidizable optical polymer as PA generator and hydrolyzable amphiphilic polymer as particle matrix to provide water solubility. The obtained SPNs are readily degraded by myeloperoxidase and lipase abundant in phagocytes, transforming from nonfluorescent nanoparticles (30 nm) into NIR fluorescent ultrasmall metabolites (≈1 nm). As such, these nanoagents can be effectively cleared out via both hepatobiliary and renal excretions after systematic administration, leaving no toxicity to living mice. Particularly these nanoagents possess high photothermal conversion efficiencies and emit bright PA signals at 1064 nm, enabling sensitive NIR‐II PA imaging of both subcutaneous tumor and deep brain vasculature through intact skull in living animals at a low systematic dosage. This study thus provides a generalized molecular design toward organic metabolizable semiconducting materials for biophotonic applications in NIR‐II window. |
| first_indexed | 2024-10-01T04:58:06Z |
| format | Journal Article |
| id | ntu-10356/105841 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:58:06Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | ntu-10356/1058412023-12-29T06:48:29Z Metabolizable semiconducting polymer nanoparticles for second near-infrared photoacoustic imaging Jiang, Yuyan Upputuri, Paul Kumar Xie, Chen Zeng, Ziling Sharma, Arunima Zhen, Xu Li, Jingchao Huang, Jiaguo Pramanik, Manojit Pu, Kanyi School of Chemical and Biomedical Engineering Photoacoustic Imaging Biodegradable Materials DRNTU::Engineering::Chemical engineering Photoacoustic (PA) imaging in the second near‐infrared (NIR‐II) window (1000–1700 nm) holds great promise for deep‐tissue diagnosis due to the reduced light scattering and minimized tissue absorption; however, exploration of such a noninvasive imaging technique is greatly constrained by the lack of biodegradable NIR‐II absorbing agents. Herein, the first series of metabolizable NIR‐II PA agents are reported based on semiconducting polymer nanoparticles (SPNs). Such completely organic nanoagents consist of π‐conjugated yet oxidizable optical polymer as PA generator and hydrolyzable amphiphilic polymer as particle matrix to provide water solubility. The obtained SPNs are readily degraded by myeloperoxidase and lipase abundant in phagocytes, transforming from nonfluorescent nanoparticles (30 nm) into NIR fluorescent ultrasmall metabolites (≈1 nm). As such, these nanoagents can be effectively cleared out via both hepatobiliary and renal excretions after systematic administration, leaving no toxicity to living mice. Particularly these nanoagents possess high photothermal conversion efficiencies and emit bright PA signals at 1064 nm, enabling sensitive NIR‐II PA imaging of both subcutaneous tumor and deep brain vasculature through intact skull in living animals at a low systematic dosage. This study thus provides a generalized molecular design toward organic metabolizable semiconducting materials for biophotonic applications in NIR‐II window. MOE (Min. of Education, S’pore) Accepted version 2019-06-20T02:30:08Z 2019-12-06T21:59:06Z 2019-06-20T02:30:08Z 2019-12-06T21:59:06Z 2019 2019 Journal Article Jiang, Y., Upputuri, P. K., Xie, C., Zeng, Z., Sharma, A., Zhen, X., … Pu, K. (2019). Metabolizable semiconducting polymer nanoparticles for second near‐infrared photoacoustic imaging. Advanced Materials, 31(11), 1808166-. doi:10.1002/adma.201808166 0935-9648 https://hdl.handle.net/10356/105841 http://hdl.handle.net/10220/48854 10.1002/adma.201808166 210161 en Advanced Materials This is the peer reviewed version of the following article: Jiang, Y., Upputuri, P. K., Xie, C., Zeng, Z., Sharma, A., Zhen, X., … Pu, K. (2019). Metabolizable semiconducting polymer nanoparticles for second near‐infrared photoacoustic imaging. Advanced Materials, 31(11), 1808166-. doi:10.1002/adma.201808166, which has been published in final form at https://dx.doi.org/10.1002/adma.201808166. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. 19 p. application/pdf |
| spellingShingle | Photoacoustic Imaging Biodegradable Materials DRNTU::Engineering::Chemical engineering Jiang, Yuyan Upputuri, Paul Kumar Xie, Chen Zeng, Ziling Sharma, Arunima Zhen, Xu Li, Jingchao Huang, Jiaguo Pramanik, Manojit Pu, Kanyi Metabolizable semiconducting polymer nanoparticles for second near-infrared photoacoustic imaging |
| title | Metabolizable semiconducting polymer nanoparticles for second near-infrared photoacoustic imaging |
| title_full | Metabolizable semiconducting polymer nanoparticles for second near-infrared photoacoustic imaging |
| title_fullStr | Metabolizable semiconducting polymer nanoparticles for second near-infrared photoacoustic imaging |
| title_full_unstemmed | Metabolizable semiconducting polymer nanoparticles for second near-infrared photoacoustic imaging |
| title_short | Metabolizable semiconducting polymer nanoparticles for second near-infrared photoacoustic imaging |
| title_sort | metabolizable semiconducting polymer nanoparticles for second near infrared photoacoustic imaging |
| topic | Photoacoustic Imaging Biodegradable Materials DRNTU::Engineering::Chemical engineering |
| url | https://hdl.handle.net/10356/105841 http://hdl.handle.net/10220/48854 |
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